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Andrew D. Paterson
Researcher at University of Dundee
Publications - 9
Citations - 1402
Andrew D. Paterson is an academic researcher from University of Dundee. The author has contributed to research in topics: MAP2K7 & Type 1 diabetes. The author has an hindex of 8, co-authored 9 publications receiving 1334 citations. Previous affiliations of Andrew D. Paterson include Hospital for Sick Children.
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Journal ArticleDOI
PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2
Anudharan Balendran,Antonio Casamayor,Maria Deak,Andrew D. Paterson,Piers R. J. Gaffney,Richard A. Currie,C. Peter Downes,Dario R. Alessi +7 more
TL;DR: PDK1 and PDK2 might be the same enzyme, the substrate specificity and activity of PDK1 being regulated through its interaction with another protein(s), and PRK2 is a probable substrate for PDK 1.
Journal ArticleDOI
Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha.
TL;DR: PKBgamma which had been activated by PDK1 possessed a substrate specificity identical with that of PKBalpha and PKBbeta towards a range of peptides, and was the major isoform activated by insulin in rat L6 myotubes (a skeletal-muscle cell line).
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Serine 727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinases.
Ying Hefner,Angelika G. Börsch-Haubold,Makomoto Murakami,Jonathan I. Wilde,Sophie Pasquet,David Schieltz,Farideh Ghomashchi,John R. Yates,Christopher G. Armstrong,Andrew D. Paterson,Philip Cohen,Rikiro Fukunaga,Tony Hunter,Ichiro Kudo,Steve P. Watson,Michael H. Gelb +15 more
TL;DR: It is shown that phosphorylation of cPLA2 at both Ser-505 and Ser-727 and elevation of Ca2+ leads to its activation in agonist-stimulated cells and suggests that MNK1 or a closely related kinase is responsible for in vivo phosphorylated of c PLA2 onSer-727.
Journal ArticleDOI
Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7.
Yvonne Fleming,Christopher G. Armstrong,Nick Morrice,Andrew D. Paterson,Michel Goedert,Philip Cohen +5 more
TL;DR: It is reported that MKK3, MKK4 and MKK6 all show a strong preference for phosphorylation of the tyrosine residue of the Thr-Gly-Tyr motifs in their known substrates SAPK2a/p38, SAPK3/ p38 gamma and SAPK4/p 38 delta, demonstrating that Mkk7 is intrinsically a 'dual-specific' protein kinase.
Journal ArticleDOI
The Genetic Landscape of Renal Complications in Type 1 Diabetes.
Niina Sandholm,Natalie R. van Zuydam,Natalie R. van Zuydam,Natalie R. van Zuydam,Emma Ahlqvist,Thorhildur Juliusdottir,Harshal Deshmukh,N. William Rayner,N. William Rayner,N. William Rayner,Barbara Di Camillo,Carol Forsblom,João Fadista,Daniel Ziemek,Rany M. Salem,Rany M. Salem,Rany M. Salem,Linda T Hiraki,Marcus G. Pezzolesi,David-Alexandre Trégouët,Emma H. Dahlström,Erkka Valo,Nikolay Oskolkov,Claes Ladenvall,M. Loredana Marcovecchio,Jason D. Cooper,Francesco Sambo,Alberto Malovini,Marco Manfrini,Amy Jayne McKnight,Maria Lajer,Valma Harjutsalo,Valma Harjutsalo,Daniel Gordin,Maija Parkkonen,Jaakko Tuomilehto,Valeriya Lyssenko,Paul M. McKeigue,Stephen S. Rich,Mary Julia Brosnan,Eric B. Fauman,Riccardo Bellazzi,Peter Rossing,Peter Rossing,Peter Rossing,Samy Hadjadj,Andrzej S. Krolewski,Andrew D. Paterson,Jose C. Florez,Jose C. Florez,Joel N. Hirschhorn,Joel N. Hirschhorn,Joel N. Hirschhorn,Alexander P. Maxwell,David B. Dunger,Claudio Cobelli,Helen M. Colhoun,Leif Groop,Mark I. McCarthy,Mark I. McCarthy,Per-Henrik Groop,Per-Henrik Groop +61 more
TL;DR: Examining a more comprehensive set of genetic variants in larger numbers of subjects with type 1 diabetes characterized for a wider range of cross-sectional diabetic kidney disease phenotypes provides further evidence for the role of genetic factors influencing diabetic kidneys disease in those with type 2 diabetes and highlights some key pathways that may be responsible.