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Ann E. Woolfrey
Researcher at Fred Hutchinson Cancer Research Center
Publications - 179
Citations - 12114
Ann E. Woolfrey is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Transplantation & Hematopoietic stem cell transplantation. The author has an hindex of 52, co-authored 179 publications receiving 11100 citations. Previous affiliations of Ann E. Woolfrey include Cleveland Clinic & University of Minnesota.
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Journal ArticleDOI
Comparison of outcomes of unrelated bone marrow and umbilical cord blood transplants in children with acute leukemia.
Vanderson Rocha,Jacqueline M. Cornish,Eric L. Sievers,Alexandra H. Filipovich,Franco Locatelli,C Peters,Mats Remberger,Gérard Michel,William Arcese,Sandro Dallorso,Karin Tiedemann,Alessandro Busca,Kawah Chan,Shunichi Kato,Juan Ortega,Marcus R. Vowels,Axel R. Zander,Gerard Souillet,Anthony Oakill,Ann E. Woolfrey,Andrea L. Pay,Ann Green,Federico Garnier,Irina Ionescu,Peter Wernet,Girolamo Sirchia,Pablo Rubinstein,Sylvie Chevret,Eliane Gluckman +28 more
TL;DR: The use of UCBT, as a source of hematopoietic stem cells, is a reasonable option for children with AL lacking an acceptably matched unrelated marrow donor.
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Peripheral-Blood Stem Cells versus Bone Marrow from Unrelated Donors
Claudio Anasetti,Brent R. Logan,Stephanie J. Lee,Edmund K. Waller,Daniel J. Weisdorf,John R. Wingard,Corey Cutler,Peter Westervelt,Ann E. Woolfrey,Stephen Couban,Gerhard Ehninger,Laura Johnston,Richard T. Maziarz,Michael A. Pulsipher,David L. Porter,Shin Mineishi,John M. McCarty,Shakila P. Khan,Paolo Anderlini,William I. Bensinger,Susan F. Leitman,Scott D. Rowley,Christopher Bredeson,Shelly L. Carter,Mary M. Horowitz,Dennis L. Confer +25 more
TL;DR: A phase 3, multicenter, randomized trial of transplantation of peripheral-blood stem cells versus bone marrow from unrelated donors did not detect significant survival differences, and exploratory analyses of secondary end points indicated that peripheral- Blood stem cells may reduce the risk of graft failure, whereas bone marrow may reduceThe risk of chronic GVHD.
Journal ArticleDOI
Optimizing Outcome After Unrelated Marrow Transplantation by Comprehensive Matching of HLA Class I and II Alleles in the Donor and Recipient
Effie W. Petersdorf,Ted Gooley,Claudio Anasetti,Paul J. Martin,Anajane G. Smith,Eric Mickelson,Ann E. Woolfrey,John A. Hansen +7 more
TL;DR: It is concluded that matching HLA class I and class II alleles of the donor and recipient can improve outcome after unrelated marrow transplantation.
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Allogeneic hematopoietic cell transplantation for hematologic malignancy: relative risks and benefits of double umbilical cord blood
Claudio G. Brunstein,Jonathan A. Gutman,Daniel J. Weisdorf,Ann E. Woolfrey,Todd E. DeFor,Ted Gooley,Michael R. Verneris,Frederick R. Appelbaum,John E. Wagner,Colleen Delaney +9 more
TL;DR: It is concluded that leukemia-free survival after dUCB transplantation is comparable with that observed after MRD and MUD transplantation and for patients without an available HLA matched donor, the use of 2 partially HLA-matched UCB units is a suitable alternative.
Journal ArticleDOI
Low-dose total body irradiation (TBI) and fludarabine followed by hematopoietic cell transplantation (HCT) from HLA-matched or mismatched unrelated donors and postgrafting immunosuppression with cyclosporine and mycophenolate mofetil (MMF) can induce durable complete chimerism and sustained remissions in patients with hematological diseases
Dietger Niederwieser,Michael B. Maris,Judith A. Shizuru,Effie W. Petersdorf,Ute Hegenbart,Brenda M. Sandmaier,David G. Maloney,Barry E. Storer,Thoralf Lange,Thomas R. Chauncey,Michael W. Deininger,Wolfram Pönisch,Claudio Anasetti,Ann E. Woolfrey,Marie Térèse Little,Karl G. Blume,Peter A. McSweeney,Rainer Storb +17 more
TL;DR: HCT from HLA-matched or mismatched unrelated donors can be performed with a reduced intensity conditioning regimen in patients ineligible for conventional HCT, according to preclinical studies.