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Anna-Lena Gustavsson
Researcher at Karolinska Institutet
Publications - 6
Citations - 154
Anna-Lena Gustavsson is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Programmed cell death & Unfolded protein response. The author has an hindex of 3, co-authored 6 publications receiving 97 citations.
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Journal ArticleDOI
Drug Target Commons: A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions.
Jing Tang,Jing Tang,Ziaurrehman Tanoli,Balaguru Ravikumar,Zaid Alam,Anni Rebane,Markus Vähä-Koskela,Gopal Peddinti,Arjan J. van Adrichem,Janica Wakkinen,Alok Jaiswal,Ella Karjalainen,Prson Gautam,Liye He,Elina Parri,Suleiman A. Khan,Abhishekh Gupta,Mehreen Ali,Laxman Yetukuri,Anna-Lena Gustavsson,Brinton Seashore-Ludlow,Anne Hersey,Andrew R. Leach,John P. Overington,Gretchen A. Repasky,Krister Wennerberg,Tero Aittokallio,Tero Aittokallio +27 more
TL;DR: An open-data web platform, named Drug Target Commons (DTC), is implemented, which features tools for crowd-sourced compound-target bioactivity data annotation, standardization, curation, and intra-resource integration.
Journal ArticleDOI
Membrane-Depolarizing Channel Blockers Induce Selective Glioma Cell Death by Impairing Nutrient Transport and Unfolded Protein/Amino Acid Responses.
Mia Niklasson,Mia Niklasson,Gianluca Maddalo,Zuzana Sramkova,Zuzana Sramkova,Ercan Mutlu,Shimei Wee,Petra Sekyrova,Petra Sekyrova,Linnéa Schmidt,Nicolas Fritz,Ivar Dehnisch,Gregorios Kyriatzis,Michaela Krafčíková,Brittany Carson,Brittany Carson,Jennifer M. Feenstra,Jennifer M. Feenstra,Voichita D. Marinescu,Anna Segerman,Martin Haraldsson,Anna-Lena Gustavsson,Lars Hammarström,Annika Jenmalm Jensen,Lene Uhrbom,A. F. Maarten Altelaar,Sten Linnarsson,Per Uhlén,Lukáš Trantírek,C. Theresa Vincent,C. Theresa Vincent,Sven Nelander,Per Øyvind Enger,Per Øyvind Enger,Michael Andäng,Michael Andäng +35 more
TL;DR: The discovery that inhibiting T-type voltage-gated Ca2+ and KCa channels can effectively induce selective cell death of GIC and increase host survival in an orthotopic mouse model of human glioma is reported.
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Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability.
Gergana Popova,Marcus J.G.W. Ladds,Lars Johansson,Aljona Saleh,Johanna Larsson,Lars Sandberg,Lars Sandberg,Sara Häggblad Sahlberg,Weixing Qian,Hjalmar Gullberg,Neeraj Garg,Anna-Lena Gustavsson,Martin Haraldsson,David P. Lane,Ulrika Yngve,Sonia Lain +15 more
TL;DR: Several of the HZ analogues synthesized in this study are highly potent inhibitors of DHODH in an enzymatic assay, whilst also inhibiting cancer cell growth and viability, and activating p53-dependent transcription factor activity in a reporter cell assay.
Journal ArticleDOI
The A-CD analogue of 16 beta,17 alpha-estriol is a potent and highly selective estrogen receptor beta agonist
Claire Sauvée,Anja Schäfer,Henrik Sundén,Jian-Nong Ma,Anna-Lena Gustavsson,Ethan S. Burstein,Roger Olsson,Roger Olsson,Roger Olsson +8 more
TL;DR: This A-CD analogue of 16 beta, 17 alpha-estriol is a highly selective (500-fold) ER beta full agonist over ER alpha with a pEC(50) of 7.7 at ER beta.
Journal ArticleDOI
Small Molecule Screens Identify CDK8-Inhibitors As Candidate Diamond-Blackfan Anemia Drugs
Jun Chen,Kavitha Siva,Tomasz Rzymski,Lars Johansson,Thomas Lundbäck,Lorena Nunez Villacis,Fredrik Ek,Bingrui Wang,Amee J George,Yang Wan,Lihong Shi,Melissa IIsley,Agatheeswaran Subramaniam,Mayur Vilas Jain,Shubhranshu Debnath,Abdul Ghani Alattar,Hanna Axelsson,Milena Mazan,Eliza Majewska,Ulf Tedgård,Marcin W. Wlodarski,Anna-Lena Gustavsson,Roger Olsson,Michal Mikula,Xiaofan Zhu,Krzysztof Brzózka,Ross D. Hannan,Johan Flygare +27 more
TL;DR: It is shown that bone marrow failure and anemia in the DBA mouse model is partially rescued (RBC and Hemoglobin levels, p<0.001) after 8 daily oral doses of CDK8 inhibitor Sel120-34A.