C
Cristin McCabe
Researcher at Broad Institute
Publications - 16
Citations - 2595
Cristin McCabe is an academic researcher from Broad Institute. The author has contributed to research in topics: Genome-wide association study & Gene. The author has an hindex of 10, co-authored 16 publications receiving 2119 citations. Previous affiliations of Cristin McCabe include Brigham and Women's Hospital & Harvard University.
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Journal ArticleDOI
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis
Ashley Beecham,Nikolaos A. Patsopoulos,Nikolaos A. Patsopoulos,Dionysia K. Xifara,Mary F. Davis,Anu Kemppinen,Chris Cotsapas,Chris Cotsapas,Tejas S. Shah,Chris C. A. Spencer,David R. Booth,An Goris,Annette Bang Oturai,Janna Saarela,Bertrand Fontaine,Bernhard Hemmer,C. Martin,Frauke Zipp,Sandra D'Alfonso,Filippo Martinelli-Boneschi,Bruce V. Taylor,Hanne F. Harbo,Ingrid Kockum,Jan Hillert,Tomas Olsson,Maria Ban,Jorge R. Oksenberg,Rogier Q. Hintzen,Lisa F. Barcellos,Lisa F. Barcellos,Lisa F. Barcellos,Cristina Agliardi,Lars Alfredsson,Mehdi Alizadeh,Carl A. Anderson,Robert Andrews,Helle Bach Søndergaard,Amie Baker,Gavin Band,Sergio E. Baranzini,Nadia Barizzone,Jeffrey C. Barrett,Céline Bellenguez,Laura Bergamaschi,Luisa Bernardinelli,Achim Berthele,Viola Biberacher,Thomas M.C. Binder,Hannah Blackburn,Izaura Lima Bomfim,Paola Brambilla,Simon Broadley,Bruno Brochet,Lou Brundin,Dorothea Buck,Helmut Butzkueven,Helmut Butzkueven,Stacy J. Caillier,William Camu,Wassila Carpentier,Paola Cavalla,Elisabeth Gulowsen Celius,Irene Coman,Giancarlo Comi,Lucia Corrado,Leentje Cosemans,Isabelle Cournu-Rebeix,Bruce A.C. Cree,Daniele Cusi,Vincent Damotte,Gilles Defer,Silvia Delgado,Panos Deloukas,Alessia Di Sapio,Alexander T. Dilthey,Peter Donnelly,Bénédicte Dubois,Martin Duddy,Sarah Edkins,Irina Elovaara,Federica Esposito,Nikos Evangelou,Barnaby Fiddes,Judith Field,Andre Franke,Colin Freeman,Irene Y. Frohlich,Daniela Galimberti,Christian Gieger,Pierre-Antoine Gourraud,Christiane Graetz,Andrew Graham,Verena Grummel,Clara Guaschino,Athena Hadjixenofontos,Hakon Hakonarson,Christopher Halfpenny,Gillian L Hall,Per Hall,Anders Hamsten,James Harley,Timothy Harrower,Clive Hawkins,Garrett Hellenthal,Charles Hillier,Jeremy Hobart,M.-M. Hoshi,Sarah E. Hunt,Maja Jagodic,Ilijas Jelcic,Ilijas Jelcic,Angela Jochim,B. E. Kendall,Allan G. Kermode,Allan G. Kermode,Trevor J. Kilpatrick,Keijo Koivisto,Ioanna Konidari,Thomas Korn,Helena C. Kronsbein,Cordelia Langford,Malin Larsson,Mark Lathrop,Mark Lathrop,Christine Lebrun-Frenay,Jeannette Lechner-Scott,Michelle Lee,Maurizio Leone,Virpi Leppa,Giuseppe Liberatore,Benedicte A. Lie,Christina M. Lill,Christina M. Lill,Magdalena Lindén,Jenny Link,Felix Luessi,Jan Lycke,Fabio Macciardi,Fabio Macciardi,Satu Männistö,Clara P. Manrique,Roland Martin,Roland Martin,Vittorio Martinelli,Deborah F. Mason,Gordon Mazibrada,Cristin McCabe,Inger Lise Mero,Julia Y Mescheriakova,Loukas Moutsianas,Kjell-Morten Myhr,Guy Nagels,Richard Nicholas,Petra Nilsson,Fredrik Piehl,Matti Pirinen,Siân Price,Hong Quach,Mauri Reunanen,Wim Robberecht,Neil Robertson,Mariaemma Rodegher,David Rog,Marco Salvetti,Nathalie Schnetz-Boutaud,Finn Sellebjerg,Rebecca C. Selter,Catherine Schaefer,Sandip Shaunak,Ling Shen,Simon Shields,Volker Siffrin,Mark Slee,Per Soelberg Sørensen,Melissa Sorosina,Mireia Sospedra,Mireia Sospedra,Anne Spurkland,Amy Strange,Emilie Sundqvist,Vincent Thijs,J W Thorpe,Anna Ticca,Pentti J. Tienari,Cornelia M. van Duijn,Elizabeth Visser,Steve Vucic,Helga Westerlind,James S. Wiley,Alastair Wilkins,James F. Wilson,Juliane Winkelmann,John Zajicek,Eva Zindler,Jonathan L. Haines,Margaret A. Pericak-Vance,Adrian J. Ivinson,Graeme J. Stewart,David A. Hafler,David A. Hafler,Stephen L. Hauser,Alastair Compston,Gil McVean,Philip L. De Jager,Philip L. De Jager,Stephen Sawcer,Jacob L. McCauley +206 more
TL;DR: This study enhances the catalog of multiple sclerosis risk variants and illustrates the value of fine mapping in the resolution of GWAS signals.
Journal ArticleDOI
Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes.
Towfique Raj,Katie Rothamel,Sara Mostafavi,Chun Ye,Mark Lee,Mark Lee,Joseph M. Replogle,Joseph M. Replogle,Ting Feng,Michelle Lee,Natasha Asinovski,Irene Frohlich,Selina Imboywa,Alina Von Korff,Yukinori Okada,Nikolaos A. Patsopoulos,Scott Davis,Cristin McCabe,Cristin McCabe,Hyun Il Paik,Gyan Srivastava,Soumya Raychaudhuri,David A. Hafler,David A. Hafler,Daphne Koller,Aviv Regev,Aviv Regev,Nir Hacohen,Nir Hacohen,Diane Mathis,Christophe Benoist,Barbara E. Stranger,Philip L. De Jager +32 more
TL;DR: This paper performed an expression quantitative trait locus (eQTL) study of purified CD4+ T cells and monocytes, representing adaptive and innate immunity, in a multi-ethnic cohort of 461 healthy individuals.
Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci
Gyan Srivastava,Katie Lunnon,Jeremy D. Burgess,Lei Yu,Jason Ernst,Cristin McCabe,Anna Tang,Towfique Raj,Joseph M. Replogle,Wendy Brodeur,Stacey Gabriel,Curtis S. Younkin,Fanggeng Zou,Moshe Szyf,Alexander Meissner,Nilufer Ertekin-Taner,Manolis Kellis,Jonathan Mill,Philip L. De Jager,Leonard C. Schalkwyk,Matthew L. Eaton,Matthew L. Eaton,Brendan T. Keenan,High Seng Chai,Steven G. Younkin,Charles B. Epstein,Julie A. Schneider,Bradley E. Bernstein,Lori B. Chibnik,David A. Bennett +29 more
TL;DR: The analyses suggest that DNA methylation changes may have a role in the onset of AD since (1) they are seen in presymptomatic subjects and (2) six of the validated genes connect to a known AD susceptibility gene network.
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis
Ashley Beecham,Nikolaos A. Patsopoulos,Nikolaos A. Patsopoulos,Dionysia K. Xifara,Mary F. Davis,Anu Kemppinen,Chris Cotsapas,Chris Cotsapas,Tejas S. Shah,Chris C. A. Spencer,David R. Booth,An Goris,Annette Bang Oturai,Janna Saarela,Bertrand Fontaine,Bernhard Hemmer,C. Martin,Frauke Zipp,Sandra D'Alfonso,Filippo Martinelli-Boneschi,Bruce V. Taylor,Hanne F. Harbo,Ingrid Kockum,Jan Hillert,Tomas Olsson,Maria Ban,Jorge R. Oksenberg,Rogier Q. Hintzen,Lisa F. Barcellos,Lisa F. Barcellos,Lisa F. Barcellos,Cristina Agliardi,Lars Alfredsson,Mehdi Alizadeh,Carl A. Anderson,Robert Andrews,Helle Bach Søndergaard,Amie Baker,Gavin Band,Sergio E. Baranzini,Nadia Barizzone,Jeffrey C. Barrett,Céline Bellenguez,Laura Bergamaschi,Luisa Bernardinelli,Achim Berthele,Viola Biberacher,Thomas M.C. Binder,Hannah Blackburn,Izaura Lima Bomfim,Paola Brambilla,Simon Broadley,Bruno Brochet,Lou Brundin,Dorothea Buck,Helmut Butzkueven,Helmut Butzkueven,Stacy J. Caillier,William Camu,Wassila Carpentier,Paola Cavalla,Elisabeth Gulowsen Celius,Irene Coman,Giancarlo Comi,Lucia Corrado,Leentje Cosemans,Isabelle Cournu-Rebeix,Bruce A.C. Cree,Daniele Cusi,Vincent Damotte,Gilles Defer,Silvia Delgado,Panos Deloukas,Alessia Di Sapio,Alexander T. Dilthey,Peter Donnelly,Bénédicte Dubois,Martin Duddy,Sarah Edkins,Irina Elovaara,Federica Esposito,Nikos Evangelou,Barnaby Fiddes,Judith Field,Andre Franke,Colin Freeman,Irene Y. Frohlich,Daniela Galimberti,Christian Gieger,Pierre-Antoine Gourraud,Christiane Graetz,Andrew Graham,Verena Grummel,Clara Guaschino,Athena Hadjixenofontos,Hakon Hakonarson,Christopher Halfpenny,Gillian L Hall,Per Hall,Anders Hamsten,James Harley,Timothy Harrower,Clive Hawkins,Garrett Hellenthal,Charles Hillier,Jeremy Hobart,M.-M. Hoshi,Sarah E. Hunt,Maja Jagodic,Ilijas Jelcic,Ilijas Jelcic,Angela Jochim,B. E. Kendall,Allan G. Kermode,Allan G. Kermode,Trevor J. Kilpatrick,Keijo Koivisto,Ioanna Konidari,Thomas Korn,Helena C. Kronsbein,Cordelia Langford,Malin Larsson,Mark Lathrop,Mark Lathrop,Christine Lebrun-Frenay,Jeannette Lechner-Scott,Michelle Lee,Maurizio Leone,Virpi Leppa,Giuseppe Liberatore,Benedicte A. Lie,Christina M. Lill,Christina M. Lill,Magdalena Lindén,Jenny Link,Felix Luessi,Jan Lycke,Fabio Macciardi,Fabio Macciardi,Satu Männistö,Clara P. Manrique,Roland Martin,Roland Martin,Vittorio Martinelli,Deborah F. Mason,Gordon Mazibrada,Cristin McCabe,Inger Lise Mero,Julia Y Mescheriakova,Loukas Moutsianas,Kjell-Morten Myhr,Guy Nagels,Richard Nicholas,Petra Nilsson,Fredrik Piehl,Matti Pirinen,Siân Price,Hong Quach,Mauri Reunanen,Wim Robberecht,Neil Robertson,Mariaemma Rodegher,David Rog,Marco Salvetti,Nathalie Schnetz-Boutaud,Finn Sellebjerg,Rebecca C. Selter,Catherine Schaefer,Sandip Shaunak,Ling Shen,Simon Shields,Volker Siffrin,Mark Slee,Per Soelberg Sørensen,Melissa Sorosina,Mireia Sospedra,Mireia Sospedra,Anne Spurkland,Amy Strange,Emilie Sundqvist,Vincent Thijs,J W Thorpe,Anna Ticca,Pentti J. Tienari,Cornelia M. van Duijn,Elizabeth Visser,Steve Vucic,Helga Westerlind,James S. Wiley,Alastair Wilkins,James F. Wilson,Juliane Winkelmann,John Zajicek,Eva Zindler,Jonathan L. Haines,Margaret A. Pericak-Vance,Adrian J. Ivinson,Graeme J. Stewart,David A. Hafler,David A. Hafler,Stephen L. Hauser,Alastair Compston,Gil McVean,Philip L. De Jager,Philip L. De Jager,Stephen Sawcer,Jacob L. McCauley +206 more
TL;DR: Using the ImmunoChip custom genotyping array, this article analyzed 14,498 subjects with multiple sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 potentially associated regions (P < 1.0 × 10(-4)).
Journal ArticleDOI
Genetic Susceptibility for Alzheimer Disease Neuritic Plaque Pathology
Joshua M. Shulman,Joshua M. Shulman,Kewei Chen,Brendan T. Keenan,Brendan T. Keenan,Brendan T. Keenan,Lori B. Chibnik,Lori B. Chibnik,Lori B. Chibnik,Adam S. Fleisher,Pradeep Thiyyagura,Auttawut Roontiva,Cristin McCabe,Cristin McCabe,Cristin McCabe,Nikolaos A. Patsopoulos,Nikolaos A. Patsopoulos,Nikolaos A. Patsopoulos,Jason J. Corneveaux,Lei Yu,Matthew J. Huentelman,Denis A. Evans,Julie A. Schneider,Eric M. Reiman,Eric M. Reiman,Philip L. De Jager,Philip L. De Jager,Philip L. De Jager,David A. Bennett +28 more
TL;DR: These findings enhance understanding of AD risk factors by relating validated susceptibility alleles to increased neuritic plaque pathology and implicate common genetic variation at the APP locus in the earliest, presymptomatic stages of AD.