L
Lei Yu
Researcher at Rush University Medical Center
Publications - 24
Citations - 1379
Lei Yu is an academic researcher from Rush University Medical Center. The author has contributed to research in topics: Cognitive decline & Cognition. The author has an hindex of 12, co-authored 24 publications receiving 876 citations. Previous affiliations of Lei Yu include Broad Institute.
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Journal ArticleDOI
A multi-omic atlas of the human frontal cortex for aging and Alzheimer’s disease research
Phillip L De Jager,Phillip L De Jager,Yiyi Ma,Cristin McCabe,Jishu Xu,Badri N. Vardarajan,Daniel Felsky,Daniel Felsky,Hans-Ulrich Klein,Hans-Ulrich Klein,Charles C. White,Mette A. Peters,Ben Lodgson,Parham Nejad,Anna Tang,Lara M. Mangravite,Lei Yu,Chris Gaiteri,Sara Mostafavi,Julie A. Schneider,David A. Bennett +20 more
TL;DR: The systematic profiling of the dorsolateral prefrontal cortex obtained from a subset of autopsied individuals enrolled in the Religious Orders Study or the Rush Memory and Aging Project, which are jointly designed prospective studies of aging and dementia with detailed, longitudinal cognitive phenotyping during life and a quantitative, structured neuropathologic examination after death, is initiated.
Journal ArticleDOI
Common variants at 12q14 and 12q24 are associated with hippocampal volume
Joshua C. Bis,Charles DeCarli,Albert V. Smith,Fedde van der Lijn,Fabrice Crivello,Fabrice Crivello,Myriam Fornage,Stephanie Debette,Stephanie Debette,Joshua M. Shulman,Joshua M. Shulman,Helena Schmidt,Velandai Srikanth,Velandai Srikanth,Maaike Schuur,Lei Yu,Seung Hoan Choi,Sigurdur Sigurdsson,Benjamin F.J. Verhaaren,Anita L. DeStefano,Jean-Charles Lambert,Clifford R. Jack,Maksim Struchalin,Jim Stankovich,Carla A. Ibrahim-Verbaas,Debra A. Fleischman,Alex P. Zijdenbos,Tom den Heijer,Bernard Mazoyer,Bernard Mazoyer,Laura H. Coker,Christian Enzinger,Patrick Danoy,Najaf Amin,Konstantinos Arfanakis,Konstantinos Arfanakis,Mark A. van Buchem,Renée F A G de Bruijn,Alexa S. Beiser,Carole Dufouil,Juebin Huang,Margherita Cavalieri,Russell Thomson,Wiro J. Niessen,Wiro J. Niessen,Lori B. Chibnik,Lori B. Chibnik,Gauti Kjartan Gislason,Albert Hofman,Aleksandra Pikula,Philippe Amouyel,Kevin B. Freeman,Thanh G. Phan,Ben A. Oostra,Jason L. Stein,Sarah E. Medland,Sarah E. Medland,Alejandro Arias Vasquez,Derrek P. Hibar,Margaret J. Wright,Barbara Franke,Nicholas G. Martin,Paul M. Thompson,Mike A. Nalls,André G. Uitterlinden,Rhoda Au,Alexis Elbaz,Richard Beare,Richard Beare,John C. van Swieten,Oscar L. Lopez,Tamara B. Harris,Vincent Chouraki,Monique M.B. Breteler,Monique M.B. Breteler,Monique M.B. Breteler,Philip L. De Jager,Philip L. De Jager,James T. Becker,Meike W. Vernooij,David S. Knopman,Franz Fazekas,Philip A. Wolf,Aad van der Lugt,Vilmundur Gudnason,William T. Longstreth,Matthew A. Brown,David A. Bennett,Cornelia M. van Duijn,Cornelia M. van Duijn,Thomas H. Mosley,Reinhold Schmidt,Christophe Tzourio,Christophe Tzourio,Lenore J. Launer,M. Arfan Ikram,Sudha Seshadri +96 more
TL;DR: In this article, a genome-wide association study (GWAS) of dementia-free persons (n = 9,232) identified 46 SNPs at four loci with P values of <4.0 × 10(-7).
Journal ArticleDOI
Sex differences in Alzheimer’s disease and common neuropathologies of aging
Shahram Oveisgharan,Zoe Arvanitakis,Lei Yu,José Marcelo Farfel,José Marcelo Farfel,Julie A. Schneider,David A. Bennett +6 more
TL;DR: Postmortem data from 1453 persons who participated in one of two longitudinal community-based studies of older adults help elucidate the neuropathologic footprint of sex difference in AD and other common brain pathologies of aging.
Posted ContentDOI
A multi-omic atlas of the human frontal cortex for aging and Alzheimer's disease research
Phillip L De Jager,Yiyi Ma,Cristin McCabe,Jishu Xu,Badri N. Vardarajan,Daniel Felsky,Hans-Ulrich Klein,Charles C. White,Mette A. Peters,Ben Lodgson,Parham Nejad,Anna Tang,Lara M. Mangravite,Lei Yu,Chris Gaiteri,Sara Mostafavi,Julie A. Schneider,David A. Bennett +17 more
TL;DR: The systematic profiling of the dorsolateral prefrontal cortex obtained from a subset of autopsied individuals enrolled in the Religious Orders Study or the Rush Memory and Aging Project, which are jointly designed and belong to a very few prospective studies of aging and dementia, is initiated.
Journal ArticleDOI
Association of APOE with tau-tangle pathology with and without β-amyloid.
José Marcelo Farfel,José Marcelo Farfel,Lei Yu,Philip L. De Jager,Philip L. De Jager,Philip L. De Jager,Julie A. Schneider,David A. Bennett,David A. Bennett +8 more
TL;DR: The presence of APOE ε4 and ε2 alleles was not associated with PHF-tau tangles in the absence of β-amyloid, and the data provide additional evidence that PHf-t Tau tangle may reflect a pathologic process distinct from Alzheimer's disease.