Anne Imberty

TL;DR: On the whole, both NMR and molecular dynamics simulations predict the molecule to be flexible, and to visit a large number of conformations while maintaining an extended overall shape.

TL;DR: A supramolecular approach based on the use of a constant short PNA tag to direct the combinatorial pairing of fragment, which yields fast exchange kinetics, while still delivering the benefits of cooperativity, and provides favourable properties for analytical deconvolution by MALDI.

TL;DR: Conformational studies of natural compounds and synthetic analogs of the Nod factors have been performed combining molecular dynamics simulations in explicit water and NMR, revealing that the glycosidic head group can adopt only restricted conformations, whereas chemical modifications of the lipid chains influence the global shape of the molecules.

TL;DR: Low-valency glycoclusters based on a triazine core bearing D-galactose and L-fucose epitopes are able to inhibit biofilm formation by Pseudomonas aeruginosa.

TL;DR: N-Acetyllactosamine derivative 4, which has a methylene amide tether between C-6 and C-2', was enzymatically glycosylated using rat liver alpha-2,6-sialyl transferase or recombinant human fucosyltransferase V to give conformationally constrained trisaccharides 5 and 6, respectively.