Anne Imberty

TL;DR: It is demonstrated that LecB strongly binds to the glycosylated moieties of β1-integrins on the basolateral plasma membrane of epithelial cells and causes rapid integrin endocytosis, which provides a mechanistic explanation for this unique endocytic process.

TL;DR: This research has focused on the chemical synthesis of "drug-like" low-molecular-weight inhibitors that circumvent drawbacks typically associated with natural oligosaccharides.

TL;DR: Production and properties of the native CV-IIL, which is probably also a quorum-sensing-driven secondary metabolite, appearing concomitantly with violacein, are described.

TL;DR: The analysis of the available crystal structures of bacterial lectins helps deciphering the structure/function relationship involving this important class of protein, and structure-based design of glycomimetics and glycodendrimers resulted in very high affinity ligands that open the route towards novel anti-infectious strategies.