Anne Imberty

TL;DR: It is demonstrated that conformationally restricted oligosaccharides can act as acceptors for glycosyltransferases and correlations of the conformational properties of N-acetyl lactosamine and several preorganized derivatives suggest that preorganization of acceptors in conformations that are favorable for recognition by a transferase may improve catalytic efficiencies.

TL;DR: In this article, the authors developed toCNF cryogels containing various types of β-Cyclodextrins derivatives by physical adsorption, and the results were consistent with the estimated binding capacity.

TL;DR: SaroL-1 from the lower eukaryote Salpingoeca rosetta was predicted to contain both β-trefoil and aerolysin-like pore-forming domain, with a stronger affinity for cancer-related α-galactosylated epitopes such as glycosphingolipid Gb3 embedded in giant unilamellar vesicles or cell membranes.

TL;DR: Rational design and synthesis of bifunctional C- or N-fucosides, generated by connecting these fragments to a fucoside core using a panel of rationally selected linkers are reported.

TL;DR: Two distinct structures of AA(Gly)B, a dual-specificity blood group synthase, are described in complex with a UDP-galactose derivative in which the O6'' atom is protected by a 2-nitrobenzyl group, paving the way for kinetic crystallography experiments aiming at trapping and characterizing reaction-intermediate states in the mechanism of enzymatic glycosyl transfer.