Anne Imberty

TL;DR: Evaluation in a cell-based anti-adhesive assay highlighted a limited decrease in adhesion for the fucosylated glycocluster, which confirmed that these TPE-based glycoclusters are indeed LecA and LecB high-affinity ligands.

TL;DR: It is concluded that the directionality of the GAG chain is essential for the binding and subsequent activation of FGF-1 and the relative biological activity of the compounds with regular substitution pattern can be inferred from their values of IC50.

TL;DR: PVL binding is specific to cancer tissue and weak or no labeling is observed for healthy ones, except for stomach glands that present unique αGlcNAc-presenting mucins, which makes it a useful tool for labeling agalacto-glycans in cancer or other diseases.

TL;DR: Fold recognition was applied to the systematic analysis of the all sequences encoded by the genome of Mycoplasma tuberculosis H37Rv in order to identify new putative glycosyltransferases, and a clear relationship appeared between some sequences and some folds.

TL;DR: The results of a series of 10‐ns molecular dynamics simulations on Pseudomonas aeruginosa lectin‐II (PA‐IIL) and its complexes with four different monosaccharides are presented and it suggests that the high density peaks of the solvent around the binding site in the free protein could be the tool to predict hydroxyl group orientation of the sugar in the protein/sugar complexes.