P
Patricia Aldea
Researcher at Washington University in St. Louis
Publications - 14
Citations - 2268
Patricia Aldea is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Alzheimer's disease & Tauopathy. The author has an hindex of 11, co-authored 14 publications receiving 1816 citations. Previous affiliations of Patricia Aldea include Avid Radiopharmaceuticals.
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Journal ArticleDOI
Tau and Aβ imaging, CSF measures, and cognition in Alzheimer’s disease
Matthew R. Brier,Brian A. Gordon,Karl A. Friedrichsen,John E. McCarthy,Ari Stern,Jon Christensen,Christopher J. Owen,Patricia Aldea,Yi Su,Jason Hassenstab,Nigel J. Cairns,David M. Holtzman,Anne M. Fagan,John C. Morris,Tammie L.S. Benzinger,Beau M. Ances +15 more
TL;DR: Tau deposition in the temporal lobe more closely tracked dementia status and was a better predictor of cognitive performance than Aβ deposition in any region of the brain, supporting models of AD where tau pathology closely tracks changes in brain function that are responsible for the onset of early symptoms in AD.
Journal ArticleDOI
Regional variability of imaging biomarkers in autosomal dominant Alzheimer’s disease
Tammie L.S. Benzinger,Tyler Blazey,Clifford R. Jack,Robert A. Koeppe,Yi Su,Chengjie Xiong,Marcus E. Raichle,Abraham Z. Snyder,Beau M. Ances,Randall J. Bateman,Nigel J. Cairns,Anne M. Fagan,Alison Goate,Daniel S. Marcus,Paul S. Aisen,Jon Christensen,Lindsay Ercole,Russ C. Hornbeck,Angela M. Farrar,Patricia Aldea,Mateusz S. Jasielec,Christopher J. Owen,Xianyun Xie,Richard Mayeux,Adam M. Brickman,Eric McDade,William E. Klunk,Chester A. Mathis,John M. Ringman,Paul M. Thompson,Bernardino Ghetti,Andrew J. Saykin,Reisa A. Sperling,Keith A. Johnson,Stephen Salloway,Stephen Correia,Peter R. Schofield,Peter R. Schofield,Colin L. Masters,Christopher C. Rowe,Victor L. Villemagne,Ralph N. Martins,Sebastien Ourselin,Martin N. Rossor,Nick C. Fox,David M. Cash,Michael W. Weiner,David M. Holtzman,Virginia Buckles,Krista L. Moulder,John C. Morris +50 more
TL;DR: An integrated whole-brain analysis of three major imaging techniques found that most gray-matter structures with amyloid plaques later have hypometabolism followed by atrophy, and a hypermetabolic phase was identified for some cortical regions, including the precuneus and posterior cingulate.
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Cerebrospinal fluid tau and ptau181 increase with cortical amyloid deposition in cognitively normal individuals: Implications for future clinical trials of Alzheimer's disease
Anne M. Fagan,Mark A. Mintun,Aarti R. Shah,Patricia Aldea,Catherine M. Roe,Robert H. Mach,Daniel S. Marcus,John C. Morris,David M. Holtzman +8 more
TL;DR: This work reports a positive linear relationship between CSF tau/ptau181 (primary constituents of neurofibrillary tangles) with the amount of cortical amyloid and observes a strong inverse relationship of cortical PIB binding with CSF Aβ42 but not for plasma Aβ species.
Journal ArticleDOI
Evaluation of Tau Imaging in Staging Alzheimer Disease and Revealing Interactions Between β-Amyloid and Tauopathy
Liang Wang,Tammie L.S. Benzinger,Yi Su,Jon Christensen,Karl A. Friedrichsen,Patricia Aldea,Jonathan McConathy,Nigel J. Cairns,Anne M. Fagan,John C. Morris,Beau M. Ances +10 more
TL;DR: Use of [18F]-AV-1451 has a potential for staging of the preclinical and clinical phases of AD and the associations among β-amyloid, tau, and volume loss are assessed.
Journal ArticleDOI
Positron Emission Tomography Imaging With [18F]flortaucipir and Postmortem Assessment of Alzheimer Disease Neuropathologic Changes
Adam S. Fleisher,Michael J. Pontecorvo,Michael D. Devous,Ming Lu,Anupa Arora,Stephen P Truocchio,Patricia Aldea,Matthew Flitter,Tricia Locascio,Marybeth Devine,Andrew Siderowf,Thomas G. Beach,Thomas J. Montine,Geidy E. Serrano,Craig Curtis,Allison Perrin,Stephen Salloway,Misty Daniel,Charles Wellman,Abhinay D. Joshi,David J. Irwin,Val J. Lowe,William W. Seeley,Milos D. Ikonomovic,Joseph C. Masdeu,Ian Kennedy,Thomas S. Harris,Michael Navitsky,Sudeepti Southekal,Mark A. Mintun,A Study Investigators +30 more
TL;DR: The findings suggest that PET imaging with [18F]flortaucipir could be used to identify the density and distribution of AD-type tau pathology and the presence of high levels of AD neuropathological change.