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Anthony Realini
Researcher at West Virginia University
Publications - 14
Citations - 939
Anthony Realini is an academic researcher from West Virginia University. The author has contributed to research in topics: Glaucoma & Genome-wide association study. The author has an hindex of 11, co-authored 14 publications receiving 818 citations.
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Journal ArticleDOI
Common Variants at 9p21 and 8q22 Are Associated with Increased Susceptibility to Optic Nerve Degeneration in Glaucoma
Janey L. Wiggs,Brian L. Yaspan,Michael A. Hauser,Jae H. Kang,R. Rand Allingham,Lana M. Olson,Wael Abdrabou,Baojian Fan,Dan Y. Wang,Wendy Brodeur,Donald L. Budenz,Joseph Caprioli,Andrew Crenshaw,Kristy Crooks,E. DelBono,Kimberly F. Doheny,David S. Friedman,Douglas E. Gaasterland,Terry Gaasterland,Cathy C. Laurie,Richard K. Lee,Paul R. Lichter,Stephanie Loomis,Yutao Liu,Felipe A. Medeiros,Catherine A. McCarty,Daniel B. Mirel,Sayoko E. Moroi,David C. Musch,Anthony Realini,Frank W. Rozsa,Joel S. Schuman,Kathleen M. Scott,Kuldev Singh,Joshua D. Stein,Edward H. Trager,Paul C. VanVeldhuisen,Douglas Vollrath,Gadi Wollstein,Sachiko Yoneyama,Kang Zhang,Robert N. Weinreb,Jason Ernst,Manolis Kellis,Tomohiro Masuda,Donald J. Zack,Julia E. Richards,Margaret A. Pericak-Vance,Louis R. Pasquale,Jonathan L. Haines +49 more
TL;DR: The authors performed a meta-analysis of two independent genome-wide association studies for primary open angle glaucoma (POAG) followed by a normal pressure (NPG) defined by intraocular pressure (IOP) less than 22 mmHg subgroup analysis.
Common Variants at 9p21 and 8q22 Are Associated with Increased Susceptibility to Optic Nerve Degeneration in Glaucoma
Janey L. Wiggs,Brian L. Yaspan,Michael A. Hauser,Jae H. Kang,R. Rand Allingham,Lana M. Olson,Wael Abdrabou,Baojian Fan,Dan Y. Wang,Wendy Brodeur,Donald L. Budenz,Joseph Caprioli,Andrew Crenshaw,Kristy Crooks,E. DelBono,Kimberly F. Doheny,David S. Friedman,Douglas E. Gaasterland,Terry Gaasterland,Cathy C. Laurie,Richard K. Lee,Paul R. Lichter,Stephanie Loomis,Yutao Liu,Felipe A. Medeiros,Catherine A. McCarty,Daniel B. Mirel,Sayoko E. Moroi,David C. Musch,Anthony Realini,Frank W. Rozsa,Joel S. Schuman,Kathleen M. Scott,Kuldev Singh,Joshua D. Stein,Edward H. Trager,Paul C. VanVeldhuisen,Douglas Vollrath,Gadi Wollstein,Sachiko Yoneyama,Kang Zhang,Robert N. Weinreb,Jason Ernst,Manolis Kellis,Tomohiro Masuda,Donald J. Zack,Julia E. Richards,Margaret A. Pericak-Vance,Louis R. Pasquale,Jonathan L. Haines +49 more
TL;DR: It is suggested that neuro-protective therapies targeting TGF-beta signaling could be effective for multiple forms of glaucoma, and genomic pathway analysis showed an association between the T GF-beta pathway and NPG.
Journal ArticleDOI
Discovery and Functional Annotation of SIX6 Variants in Primary Open-Angle Glaucoma
Megan U. Carnes,Yangfan P. Liu,R. Rand Allingham,Benjamin T. Whigham,Shane J. Havens,Melanie E. Garrett,Chunyan Qiao,Chunyan Qiao,Nicholas Katsanis,Janey L. Wiggs,Louis R. Pasquale,Allison E. Ashley-Koch,Edwin C. Oh,Michael A. Hauser,Murray H. Brilliant,Donald L. Budenz,Hemin R. Chin,Jessica N. Cooke Bailey,John H. Fingert,David S. Friedman,Douglas E. Gaasterland,Terry Gaasterland,Jonathan L. Haines,Jae H. Kang,Richard K. Lee,Paul R. Lichter,Yutao Liu,Stephanie Loomis,Cathy Essentia McCarty,Sayoko E. Moroi,Margaret A. Pericak-Vance,Anthony Realini,Julia E. Richards,Joel S. Schuman,William K. Scott,Kuldev Singh,Arthur J. Sit,Douglas Vollrath,Robert N. Weinreb,Gadi Wollstein,Brian L. Yaspan,Donald J. Zack,Kang Zhang +42 more
TL;DR: It is hypothesized that SIX6 risk variants disrupt the development of the neural retina, leading to a reduced number of retinal ganglion cells, thereby increasing the risk of glaucoma-associated vision loss.
Journal ArticleDOI
Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases
Adriana I Iglesias,Aniket Mishra,Veronique Vitart,Yelena Bykhovskaya,René Höhn,René Höhn,Henriët Springelkamp,Gabriel Cuellar-Partida,Puya Gharahkhani,Jessica N. Cooke Bailey,Colin E. Willoughby,Xiaohui Li,Seyhan Yazar,Seyhan Yazar,Abhishek Nag,Anthony P Khawaja,Anthony P Khawaja,Ozren Polasek,David S. Siscovick,David S. Siscovick,Paul Mitchell,Yih Chung Tham,Jonathan L. Haines,Lisa S. Kearns,Caroline Hayward,Yuan Shi,Elisabeth M. van Leeuwen,Kent D. Taylor,Jie Jin Wang,Elena Rochtchina,John Attia,Rodney J. Scott,Elizabeth G. Holliday,Paul N. Baird,Jing Xie,Michael Inouye,Ananth C. Viswanathan,Xueling Sim,Pieter W.M. Bonnemaijer,Jerome I. Rotter,Nicholas G. Martin,Tanja Zeller,Richard A. Mills,Sandra E Staffieri,Jost B. Jonas,Irene Schmidtmann,Thibaud Boutin,Jae H. Kang,Sionne E. M. Lucas,Tien Yin Wong,Manfred E. Beutel,James F. Wilson,R. Rand Allingham,Murray H. Brilliant,Donald L. Budenz,William G. Christen,John H. Fingert,David S. Friedman,Douglas E. Gaasterland,Terry Gaasterland,Michael A. Hauser,Peter Kraft,Richard K. Lee,Paul R. Lichter,Yutao Liu,Stephanie Loomis,Sayoko E. Moroi,Margaret A. Pericak-Vance,Anthony Realini,Julia E. Richards,Joel S. Schuman,William K. Scott,Kuldev Singh,Arthur J. Sit,Douglas Vollrath,Robert N. Weinreb,Gadi Wollstein,Donald J. Zack,Kang Zhang,Peter Donnelly,Inês Barroso,Jenefer M. Blackwell,Jenefer M. Blackwell,Elvira Bramon,Matthew A. Brown,Juan P. Casas,Juan P. Casas,Aiden Corvin,Panos Deloukas,Audrey Duncanson,Janusz Jankowski,Janusz Jankowski,Janusz Jankowski,Hugh S. Markus,Christopher G. Mathew,Colin N. A. Palmer,Robert Plomin,Anna Rautanen,Stephen Sawcer,Richard C. Trembath,Nicholas W. Wood,Chris C. A. Spencer,Gavin Band,Céline Bellenguez,Colin Freeman,Garrett Hellenthal,Eleni Giannoulatou,Matti Pirinen,Richard G. Pearson,Amy Strange,Zhan Su,Damjan Vukcevic,Cordelia Langford,Sarah E. Hunt,Sarah Edkins,Rhian Gwilliam,Hannah Blackburn,Suzannah Bumpstead,Serge Dronov,Matthew Gillman,Emma Gray,Naomi Hammond,Alagurevathi Jayakumar,Owen T. McCann,Jennifer Liddle,Simon C. Potter,Radhi Ravindrarajah,Michelle Ricketts,Matthew Waller,Paul A. Weston,Sara Widaa,Pamela Whittaker,André G. Uitterlinden,Eranga N. Vithana,Paul J. Foster,Pirro G. Hysi,Alex W. Hewitt,Alex W. Hewitt,Chiea Chuen Khor,Louis R. Pasquale,Grant W. Montgomery,Grant W. Montgomery,Caroline C W Klaver,Caroline C W Klaver,Tin Aung,Tin Aung,Norbert Pfeiffer,David A. Mackey,Christopher J Hammond,Ching-Yu Cheng,Ching-Yu Cheng,Jamie E Craig,Yaron S. Rabinowitz,Janey L. Wiggs,Kathryn P. Burdon,Cornelia M. van Duijn,Stuart MacGregor +156 more
TL;DR: The authors identify 19 novel genetic loci associated with CCT, a subset of which is involved in rare corneal or connective tissue disorders, and implicate candidate genes acting in collagen and extracellular matrix regulation.
Journal ArticleDOI
The p53 codon 72 PRO/PRO genotype may be associated with initial central visual field defects in caucasians with primary open angle glaucoma.
Janey L. Wiggs,Alex W. Hewitt,Baojian Fan,Dan Yi Wang,Dayse F Sena,Colm O'Brien,Anthony Realini,Jamie E Craig,David P. Dimasi,David A. Mackey,Jonathan L. Haines,Louis R. Pasquale +11 more
TL;DR: It is suggested that the p53 codon 72 PRO/PRO genotype is potentially associated with early paracentral visual field defects in primary open-angle glaucoma patients.