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Paul N. Baird
Researcher at University of Melbourne
Publications - 226
Citations - 10720
Paul N. Baird is an academic researcher from University of Melbourne. The author has contributed to research in topics: Population & Macular degeneration. The author has an hindex of 53, co-authored 216 publications receiving 9399 citations. Previous affiliations of Paul N. Baird include University of Southern Queensland & University College London.
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Journal ArticleDOI
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants
Lars G. Fritsche,Wilmar Igl,Jessica N. Cooke Bailey,Felix Grassmann,Sebanti Sengupta,Jennifer L. Bragg-Gresham,Kathryn P. Burdon,Scott J. Hebbring,Cindy Wen,Mathias Gorski,Ivana K. Kim,David Cho,Donald J. Zack,Donald J. Zack,Eric H. Souied,Hendrik P. N. Scholl,Hendrik P. N. Scholl,Elisa Bala,Kristine ELee,David J. Hunter,Rebecca J. Sardell,Paul Mitchell,Joanna E. Merriam,Valentina Cipriani,Valentina Cipriani,Joshua D. Hoffman,Tina Schick,Yara T. E. Lechanteur,Robyn H. Guymer,Matthew P. Johnson,Yingda Jiang,Chloe M. Stanton,Gabri'lle H.S. Buitendijk,Xiaowei Zhan,Xiaowei Zhan,Alan M. Kwong,Alexis Boleda,Matthew Brooks,Linn Gieser,Rinki Ratnapriya,Kari Branham,Johanna R. Foerster,John R. Heckenlively,Mohammad Othman,Brendan J. Vote,Helena Liang,Emmanuelle Souzeau,Ian L. McAllister,Timothy Isaacs,Janette Hall,Stewart Lake,David A. Mackey,David A. Mackey,David A. Mackey,Ian J. Constable,Jamie E Craig,Terrie Kitchner,Zhenglin Yang,Zhenglin Yang,Zhiguang Su,Hongrong Luo,Daniel Chen,Hong Ouyang,Ken Flagg,Danni Lin,Guanping Mao,Henry Ferreyra,Klaus Stark,Claudia N von Strachwitz,Armin Wolf,Caroline Brandl,G. Rudolph,Matthias Olden,Margaux A. Morrison,Denise J. Morgan,Matthew Schu,Jeeyun Ahn,Giuliana Silvestri,Evangelia E. Tsironi,Kyu Hyung Park,Lindsay A. Farrer,Anton Orlin,Alexander J. Brucker,Mingyao Li,Christine A. Curcio,Saddek Mohand-Sa'd,José-Alain Sahel,Isabelle Audo,Mustapha Benchaboune,Angela J. Cree,Christina A Rennie,S. V. Goverdhan,Michelle Grunin,Shira Hagbi-Levi,Peter A. Campochiaro,Nicholas Katsanis,Frank G. Holz,Frédéric Blond,Frédéric Blond,Frédéric Blond,Hél'ne Blanché,Jean Fran ois Deleuze,Robert P. Igo,Barbara Truitt,Neal S. Peachey,Neal S. Peachey,Stacy M. Meuer,Chelsea E. Myers,Emily L. Moore,Ronald Klein,Michael A. Hauser,Eric A. Postel,Monique D. Courtenay,Stephen G. Schwartz,Jaclyn L. Kovach,William K. Scott,Gerald Liew,Ava Grace Tan,Bamini Gopinath,John C. Merriam,R. Theodore Smith,R. Theodore Smith,Jane C. Khan,Jane C. Khan,Jane C. Khan,Humma Shahid,Humma Shahid,Anthony T. Moore,Anthony T. Moore,Anthony T. Moore,J Allie McGrath,Renee Laux,Milam A. Brantley,Anita Agarwal,Lebriz Ersoy,Albert Caramoy,Thomas Langmann,Nicole T.M. Saksens,Eiko Kde Jong,Carel B. Hoyng,Melinda Cain,Andrea J. Richardson,Tammy M. Martin,John Blangero,Daniel E. Weeks,Bal Dhillon,Cornelia M. van Duijn,Kimberly F. Doheny,Jane Romm,Caroline C W Klaver,Caroline Hayward,Michael B. Gorin,Michael L. Klein,Paul N. Baird,Anneke I. den Hollander,Sascha Fauser,John R. WYates,John R. WYates,John R. WYates,Rando Allikmets,Jie Jin Wang,Debra A. Schaumberg,Debra A. Schaumberg,Barbara E.K. Klein,Stephanie A. Hagstrom,Itay Chowers,Andrew J. Lotery,Thierry Léveillard,Thierry Léveillard,Thierry Léveillard,Kang Zhang,Kang Zhang,Murray H. Brilliant,Alex W. Hewitt,Alex W. Hewitt,Alex W. Hewitt,Anand Swaroop,Emily Y. Chew,Margaret A. Pericak-Vance,Margaret M. DeAngelis,Dwight Stambolian,Jonathan L. Haines,Sudha K. Iyengar,Bernhard H. F. Weber,Gon'alo R. Abecasis,Iris M. Heid +185 more
TL;DR: The results support the hypothesis that rare coding variants can pinpoint causal genes within known genetic loci and illustrate that applying the approach systematically to detect new loci requires extremely large sample sizes.
Journal ArticleDOI
Seven new loci associated with age-related macular degeneration
Lars G. Fritsche,Lars G. Fritsche,Wei Chen,Wei Chen,Matthew Schu,Brian L. Yaspan,Yi Yu,Gudmar Thorleifsson,Donald J. Zack,Donald J. Zack,Satoshi Arakawa,Valentina Cipriani,Valentina Cipriani,Stephan Ripke,Stephan Ripke,Robert P. Igo,Gabriëlle H.S. Buitendijk,Xueling Sim,Xueling Sim,Daniel E. Weeks,Robyn H. Guymer,Joanna E. Merriam,Peter J. Francis,Gregory Hannum,Anita Agarwal,Ana Maria Armbrecht,Isabelle Audo,Tin Aung,Tin Aung,Gaetano R. Barile,Mustapha Benchaboune,Alan C. Bird,Alan C. Bird,Paul N. Bishop,Kari Branham,Matthew Brooks,Alexander J. Brucker,William Cade,Melinda Cain,Peter A. Campochiaro,Chi-Chao Chan,Ching-Yu Cheng,Ching-Yu Cheng,Emily Y. Chew,Kimberly A Chin,Itay Chowers,David Clayton,Radu Cojocaru,Yvette P. Conley,Belinda K. Cornes,Mark J. Daly,Baljean Dhillon,Albert O. Edwards,Evangelos Evangelou,Jesen Fagerness,Jesen Fagerness,Henry Ferreyra,James S. Friedman,Asbjorg Geirsdottir,Ronnie George,Christian Gieger,Neel Gupta,Stephanie A. Hagstrom,Simon P. Harding,Christos Haritoglou,John R. Heckenlively,Frank G. Holz,Guy Hughes,John P. A. Ioannidis,Tatsuro Ishibashi,Peronne Joseph,Gyungah Jun,Yoichiro Kamatani,Nicholas Katsanis,Claudia N. Keilhauer,Jane C. Khan,Jane C. Khan,Jane C. Khan,Ivana K. Kim,Yutaka Kiyohara,Barbara E.K. Klein,Ronald Klein,Jaclyn L. Kovach,Igor Kozak,Clara Lee,Kristine E. Lee,Peter Lichtner,Andrew J. Lotery,Thomas Meitinger,Paul Mitchell,Saddek Mohand-Said,Anthony T. Moore,Anthony T. Moore,Denise J. Morgan,Margaux A. Morrison,Chelsea E. Myers,Adam C. Naj,Yusuke Nakamura,Yukinori Okada,Anton Orlin,M. Carolina Ortube,Mohammad Othman,Chris Pappas,Kyu Hyung Park,Gayle J.T. Pauer,Neal S. Peachey,Neal S. Peachey,Olivier Poch,Rinki Ratna Priya,Robyn Reynolds,Andrea J. Richardson,Raymond Ripp,G. Rudolph,Euijung Ryu,José-Alain Sahel,Debra A. Schaumberg,Hendrik P. N. Scholl,Hendrik P. N. Scholl,Stephen G. Schwartz,William K. Scott,Humma Shahid,Humma Shahid,Haraldur Sigurdsson,Giuliana Silvestri,Theru A. Sivakumaran,R. Theodore Smith,Lucia Sobrin,Eric H Souied,Dwight Stambolian,Hreinn Stefansson,Gwen M. Sturgill-Short,Atsushi Takahashi,Nirubol Tosakulwong,Barbara Truitt,Evangelia E. Tsironi,André G. Uitterlinden,Cornelia M. van Duijn,Lingam Vijaya,Johannes R. Vingerling,Eranga N. Vithana,Eranga N. Vithana,Andrew R. Webster,Andrew R. Webster,H.-Erich Wichmann,Thomas W. Winkler,Tien Yin Wong,Tien Yin Wong,Tien Yin Wong,Alan F. Wright,Diana Zelenika,Ming Zhang,Ming Zhang,Ling Zhao,Kang Zhang,Kang Zhang,Michael L. Klein,Gregory S. Hageman,Mark Lathrop,Kari Stefansson,Kari Stefansson,Rando Allikmets,Paul N. Baird,Michael B. Gorin,Jie Jin Wang,Jie Jin Wang,Caroline C W Klaver,Johanna M. Seddon,Margaret A. Pericak-Vance,Sudha K. Iyengar,John R.W. Yates,John R.W. Yates,John R.W. Yates,Anand Swaroop,Anand Swaroop,Bernhard H. F. Weber,Michiaki Kubo,Margaret M. DeAngelis,Thierry Léveillard,Thierry Léveillard,Thierry Léveillard,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Jonathan L. Haines,Lindsay A. Farrer,Iris M. Heid,Gonçalo R. Abecasis +185 more
TL;DR: A collaborative genome-wide association study, including >17,100 advanced AMD cases and >60,000 controls of European and Asian ancestry, identifies 19 loci associated at P < 5 × 10−8, which show enrichment for genes involved in the regulation of complement activity, lipid metabolism, extracellular matrix remodeling and angiogenesis.
Journal ArticleDOI
Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia
Virginie J. M. Verhoeven,Pirro G. Hysi,Robert Wojciechowski,Robert Wojciechowski,Qiao Fan,Jeremy A. Guggenheim,René Höhn,Stuart MacGregor,Alex W. Hewitt,Alex W. Hewitt,Abhishek Nag,Ching-Yu Cheng,Ching-Yu Cheng,Ekaterina Yonova-Doing,Xin Zhou,M. Kamran Ikram,M. Kamran Ikram,Gabriëlle H.S. Buitendijk,George McMahon,John P. Kemp,Beate St Pourcain,Claire L. Simpson,Kari-Matti Mäkelä,Terho Lehtimäki,Mika Kähönen,Andrew D. Paterson,S. Mohsen Hosseini,Hoi Suen Wong,Liang Xu,Jost B. Jonas,Olavi Pärssinen,Juho Wedenoja,Shea Ping Yip,Daniel W.H. Ho,Daniel W.H. Ho,Chi Pui Pang,Li Jia Chen,Kathryn P. Burdon,Jamie E Craig,Barbara E.K. Klein,Ronald Klein,Toomas Haller,Andres Metspalu,Chiea Chuen Khor,Chiea Chuen Khor,E-Shyong Tai,Tin Aung,Tin Aung,Eranga N. Vithana,Wan Ting Tay,Veluchamy A. Barathi,Veluchamy A. Barathi,Myopia (Cream),Peng Chen,Ruoying Li,Jiemin Liao,Yingfeng Zheng,Rick Twee-Hee Ong,Angela Döring,Complications Trial,Complications (Dcct),David M. Evans,Nicholas J. Timpson,Annemieke J.M.H. Verkerk,Thomas Meitinger,Olli T. Raitakari,Felicia Hawthorne,Tim D. Spector,Lennart C. Karssen,Mario Pirastu,Federico Murgia,Wei Ang,Aniket Mishra,Grant W. Montgomery,Craig E. Pennell,Phillippa M. Cumberland,Ioana Cotlarciuc,Paul Mitchell,Jie Jin Wang,Jie Jin Wang,Maria Schache,Sarayut Janmahasatian,Robert P. Igo,Jonathan H. Lass,Emily Y. Chew,Sudha K. Iyengar,Theo G. M. F. Gorgels,Igor Rudan,Caroline Hayward,Alan F. Wright,Ozren Polasek,Zoran Vatavuk,James F. Wilson,Brian W Fleck,Tanja Zeller,Alireza Mirshahi,Christian P. Müller,André G. Uitterlinden,Fernando Rivadeneira,Johannes R. Vingerling,Albert Hofman,Ben A. Oostra,Najaf Amin,Arthur A.B. Bergen,Yik Ying Teo,Jugnoo S Rahi,Jugnoo S Rahi,Jugnoo S Rahi,Veronique Vitart,Cathy Williams,Paul N. Baird,Tien Yin Wong,Tien Yin Wong,Konrad Oexle,Norbert Pfeiffer,David A. Mackey,David A. Mackey,Terri L. Young,Cornelia M. van Duijn,Seang-Mei Saw,Seang-Mei Saw,Seang-Mei Saw,Joan E. Bailey-Wilson,Joan E. Bailey-Wilson,Dwight Stambolian,Caroline C W Klaver,Caroline C W Klaver,Christopher J Hammond,Christopher J Hammond +128 more
TL;DR: The CREAM consortium conducted genome-wide meta-analyses, which identified 16 new loci for refractive error in individuals of European ancestry and 8 were shared with Asians, and identified 8 additional associated loci.
Journal ArticleDOI
Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration
Yi Yu,Tushar Bhangale,Jesen Fagerness,Jesen Fagerness,Stephan Ripke,Stephan Ripke,Gudmar Thorleifsson,Perciliz L. Tan,Eric H Souied,Andrea J. Richardson,Joanna E. Merriam,Gabriëlle H.S. Buitendijk,Robyn Reynolds,Soumya Raychaudhuri,Kimberly A Chin,Lucia Sobrin,Evangelos Evangelou,Phil Lee,Phil Lee,Aaron Y. Lee,Nicolas Leveziel,Donald J. Zack,Betsy Campochiaro,Peter A. Campochiaro,R. Theodore Smith,Gaetano R. Barile,Robyn H. Guymer,Ruth E Hogg,Usha Chakravarthy,Luba D Robman,Omar Gustafsson,Haraldur Sigurdsson,Ward Ortmann,Timothy W. Behrens,Kari Stefansson,Kari Stefansson,André G. Uitterlinden,Cornelia M. van Duijn,Johannes R. Vingerling,Caroline C W Klaver,Rando Allikmets,Milam A. Brantley,Paul N. Baird,Nicholas Katsanis,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,John P. A. Ioannidis,Mark J. Daly,Mark J. Daly,Robert R. Graham,Johanna M. Seddon +50 more
TL;DR: The novel variants identified in this study suggest that angiogenesis (VEGFA) and extracellular collagen matrix (FRK/COL10A1) pathways contribute to the development of advanced AMD.
Journal ArticleDOI
Multiple Common Susceptibility Variants near BMP Pathway Loci GREM1, BMP4, and BMP2 Explain Part of the Missing Heritability of Colorectal Cancer
Ian Tomlinson,Luis G. Carvajal-Carmona,Sara E. Dobbins,Albert Tenesa,Angela M. Jones,Kimberley Howarth,Claire Palles,Peter Broderick,Emma Jaeger,Susan M. Farrington,Annabelle Lewis,James G. D. Prendergast,Alan M. Pittman,Evropi Theodoratou,Bianca Olver,Marion F Walker,Steven Penegar,Ella Barclay,Nicola Whiffin,Lynn Martin,Stephane Ballereau,Amy Lloyd,Maggie Gorman,Steven J. Lubbe,Bryan Howie,Jonathan Marchini,Clara Ruiz-Ponte,Ceres Fernandez-Rozadilla,Antoni Castells,Angel Carracedo,Sergi Castellví-Bel,David Duggan,David V. Conti,Jean-Baptiste Cazier,Harry Campbell,Oliver M. Sieber,Lara Lipton,Peter Gibbs,Nicholas G. Martin,Grant W. Montgomery,Joanne P. Young,Paul N. Baird,Steven Gallinger,Polly A. Newcomb,John L. Hopper,Mark A. Jenkins,Lauri A. Aaltonen,David J. Kerr,Jeremy Peter Cheadle,Paul D.P. Pharoah,Graham Casey,Richard S. Houlston,Malcolm G. Dunlop +52 more
TL;DR: This data emphasise that genetic fine-mapping studies can deconvolute associations that have arisen owing to independent correlation of a tagSNP with more than one functional SNP, thus explaining some of the apparently missing heritability of common diseases.