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Ariel Savina
Researcher at Hoffmann-La Roche
Publications - 61
Citations - 9539
Ariel Savina is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Antigen & Antigen presentation. The author has an hindex of 29, co-authored 59 publications receiving 7967 citations. Previous affiliations of Ariel Savina include National University of Cuyo & Curie Institute.
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Journal ArticleDOI
Rab27a and Rab27b control different steps of the exosome secretion pathway
Matias Ostrowski,Nuno Carmo,Sophie Krumeich,Sophie Krumeich,Isabelle Fanget,Graça Raposo,Graça Raposo,Ariel Savina,Ariel Savina,Catarina Moita,Kristine Schauer,Kristine Schauer,Alistair N. Hume,Rui P. Freitas,Bruno Goud,Bruno Goud,Philippe Benaroch,Philippe Benaroch,Nir Hacohen,Nir Hacohen,Mitsunori Fukuda,Claire Desnos,Miguel C. Seabra,Miguel C. Seabra,Miguel C. Seabra,François Darchen,Sebastian Amigorena,Sebastian Amigorena,Luis F. Moita,Clotilde Théry,Clotilde Théry +30 more
TL;DR: The results therefore strengthen the link between MVEs and exosomes, and introduce ways of manipulating exosome secretion in vivo.
Journal ArticleDOI
Cross-presentation by dendritic cells.
Olivier Joffre,Elodie Segura,Elodie Segura,Ariel Savina,Ariel Savina,Sebastian Amigorena,Sebastian Amigorena +6 more
TL;DR: Recent advances in the understanding of the intracellular mechanisms of cross-presentation are summarized and its role in immunity and tolerance in the context of specialization between DC subsets is discussed.
Journal ArticleDOI
NOX2 Controls Phagosomal pH to Regulate Antigen Processing during Crosspresentation by Dendritic Cells
Ariel Savina,Carolina Jancic,Stéphanie Hugues,Pierre Guermonprez,Pablo Vargas,Ivan C. Moura,Ana-Maria Lennon-Duménil,Miguel C. Seabra,Graça Raposo,Sebastian Amigorena +9 more
TL;DR: A specialization of the phagocytic pathway of DCs is described that allows a fine control of antigen processing and plays a critical role in conferring DCs the ability to function as specialized phagocytes adapted to process antigens rather than kill pathogens.
Journal ArticleDOI
Exosome release is regulated by a calcium-dependent mechanism in K562 cells.
TL;DR: Interestingly, the results indicate that transferrin (Tf) stimulated exosome release in a Ca2+-dependent manner, suggesting that Tf might be a physiological stimulus for exosomes release in K562 cells.
Journal ArticleDOI
Phagocytosis and antigen presentation in dendritic cells.
Ariel Savina,Sebastian Amigorena +1 more
TL;DR: The mechanisms that control this delicate equilibrium between phagosomal degradation/cytotoxicity and antigen presentation in the different families of phagocytes are reviewed.