B
Betul Oran
Researcher at University of Texas MD Anderson Cancer Center
Publications - 240
Citations - 5241
Betul Oran is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Transplantation & Hematopoietic stem cell transplantation. The author has an hindex of 34, co-authored 201 publications receiving 3927 citations. Previous affiliations of Betul Oran include University of Texas at Austin & University of Minnesota.
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Journal ArticleDOI
Cord-blood engraftment with ex vivo mesenchymal-cell coculture.
Marcos de Lima,Ian McNiece,Simon N. Robinson,Mark F. Munsell,Mary Eapen,Mary M. Horowitz,Amin M. Alousi,Rima M. Saliba,John McMannis,Indreshpal Kaur,Partow Kebriaei,Simrit Parmar,Uday R. Popat,Chitra Hosing,Richard E. Champlin,Catherine M. Bollard,Jeffrey J. Molldrem,Roy B. Jones,Yago Nieto,Borje S. Andersson,Nina Shah,Betul Oran,Laurence J.N. Cooper,Laura L. Worth,Muzaffar H. Qazilbash,Martin Korbling,Gabriela Rondon,Stefan O. Ciurea,Doyle Bosque,I. Maewal,Paul J. Simmons,Elizabeth J. Shpall +31 more
TL;DR: Transplantation of cord-blood cells expanded ex vivo in cocultures with allogeneic mesenchymal stromal cells appeared to be safe and effective and significantly improved engraftment, as compared with unmanipulated cord blood only.
Journal ArticleDOI
Survival for older patients with acute myeloid leukemia: a population-based study.
Betul Oran,Daniel J. Weisdorf +1 more
TL;DR: Therapy for leukemia improves overall survival in older acute myeloid leukemia patients, and based on their comorbidities, most patients up to 80 years of age should be considered for treatment.
Journal ArticleDOI
Similar transplantation outcomes for acute myeloid leukemia and myelodysplastic syndrome patients with haploidentical versus 10/10 human leukocyte antigen-matched unrelated and related donors.
Antonio Di Stasi,Denái R. Milton,LM Poon,Amir Hamdi,Gabriela Rondon,Julianne Chen,Sai Ravi Pingali,Marina Konopleva,Piyanuch Kongtim,Amin M. Alousi,Muzaffar H. Qazilbash,Sairah Ahmed,Qaiser Bashir,Gheath Alatrash,Betul Oran,Chitra Hosing,Partow Kebriaei,Uday R. Popat,Elizabeth J. Shpall,Dean A. Lee,Marcos de Lima,Katayoun Rezvani,Issa F. Khouri,Richard E. Champlin,Stefan O. Ciurea +24 more
TL;DR: It is suggested that haploidentical donors can safely extend transplantation for AML/MDS patients without an HLA-matched donor, and prospective studies comparing haploIDENTical and MUD transplantation are warranted.
Journal ArticleDOI
Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells.
Nimitha R. Mathew,Nimitha R. Mathew,Francis Baumgartner,Lukas Braun,David O’Sullivan,Simone Thomas,Miguel Waterhouse,Tony Andreas Müller,Kathrin Hanke,Kathrin Hanke,Sanaz Taromi,Petya Apostolova,Anna Lena Illert,Wolfgang Melchinger,Sandra Duquesne,Annette Schmitt-Graeff,Lena Osswald,Kai-Li Yan,Arnim Weber,Sonia Tugues,Sabine Spath,Dietmar Pfeifer,Marie Follo,Rainer Claus,Michael Lübbert,Christoph Rummelt,Hartmut Bertz,Ralph Wäsch,Johanna Haag,Andrea Schmidts,Michael Schultheiss,Dominik Bettinger,Robert Thimme,Evelyn Ullrich,Yakup Tanriver,Giang Lam Vuong,Renate Arnold,Philipp Hemmati,Dominik Wolf,Markus Ditschkowski,Cordula A. Jilg,Konrad Wilhelm,C. Leiber,Sabine Gerull,Jörg Halter,Claudia Lengerke,Thomas Pabst,Thomas Schroeder,Guido Kobbe,Wolf Rösler,Soroush Doostkam,Stephan Meckel,Kathleen Stabla,Kathleen Stabla,S K Metzelder,S K Metzelder,Sebastian Halbach,Tilman Brummer,Zehan Hu,Zehan Hu,Joern Dengjel,Joern Dengjel,Björn Hackanson,Christoph Schmid,Udo Holtick,Christof Scheid,Alexandros Spyridonidis,Friedrich Stölzel,Rainer Ordemann,Lutz P. Müller,Flore Sicre-de-Fontbrune,Gabriele Ihorst,Jürgen Kuball,Jan E. Ehlert,Daniel Feger,Eva-Maria Wagner,Jean-Yves Cahn,Jacqueline Schnell,Florian Kuchenbauer,Donald Bunjes,Ronjon Chakraverty,Simon Richardson,Saar Gill,Nicolaus Kröger,Francis Ayuk,Luca Vago,Fabio Ciceri,Antonia M.S. Müller,Takeshi Kondo,Takanori Teshima,Susan Klaeger,Susan Klaeger,Bernhard Kuster,Dennis Dong Hwan Kim,Daniel J. Weisdorf,Walter J.F.M. van der Velden,Daniela Dörfel,Wolfgang Bethge,Inken Hilgendorf,Andreas Hochhaus,Geoffroy Andrieux,Melanie Börries,Hauke Busch,John M. Magenau,Pavan Reddy,Myriam Labopin,Joseph H. Antin,Andrea S. Henden,Andrea S. Henden,Geoffrey R. Hill,Geoffrey R. Hill,Glen A Kennedy,Merav Bar,Anita Sarma,Donal P. McLornan,Ghulam J. Mufti,Betul Oran,Katayoun Rezvani,Omid Shah,Robert S. Negrin,Arnon Nagler,Marco Prinz,Marco Prinz,Andreas Burchert,Andreas Neubauer,Andreas Neubauer,Dietrich W. Beelen,Andreas Mackensen,Nikolas von Bubnoff,Wolfgang Herr,Burkhard Becher,Gérard Socié,Michael A. Caligiuri,Eliana Ruggiero,Chiara Bonini,Georg Häcker,Justus Duyster,Jürgen Finke,Erika L. Pearce,Bruce R. Blazar,Robert Zeiser,Robert Zeiser +141 more
TL;DR: Findings indicate that the synergism of T cells and sorafenib is mediated via reduced ATF4 expression, causing activation of the IRF7–IL-15 axis in leukemia cells and thereby leading to metabolic reprogramming of leukemia-reactive T cells in humans.
Journal ArticleDOI
Enforced fucosylation of cord blood hematopoietic cells accelerates neutrophil and platelet engraftment after transplantation.
Uday R. Popat,Rohtesh S. Mehta,Katy Rezvani,Patricia S. Fox,Kayo Kondo,David Marin,Ian McNiece,Betul Oran,Chitra Hosing,Amanda Olson,Simrit Parmar,Nina Shah,Michael Andreeff,Partow Kebriaei,Indreshpal Kaur,Eric Yvon,Marcos de Lima,Laurence J.N. Cooper,Priti Tewari,Richard E. Champlin,Yago Nieto,Borje S. Andersson,Amin M. Alousi,Roy B. Jones,Muzaffar H. Qazilbash,Qaiser Bashir,Stefan O. Ciurea,Sairah Ahmed,Paolo Anderlini,Doyle Bosque,Catherine M. Bollard,Jeffrey J. Molldrem,Julianne Chen,Gabriela Rondon,Mike Thomas,Leonard D. Miller,Steve Wolpe,Paul J. Simmons,Simon P. Robinson,Patrick A. Zweidler-McKay,Elizabeth J. Shpall +40 more
TL;DR: Findings support ex vivo fucosylation of multipotent CD34(+) CB cells as a clinically feasible means to improve engraftment efficiency in the double CBT setting.