A
Arnold L. Rheingold
Researcher at University of California, San Diego
Publications - 1415
Citations - 35872
Arnold L. Rheingold is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Ligand & Crystal structure. The author has an hindex of 75, co-authored 1392 publications receiving 33260 citations. Previous affiliations of Arnold L. Rheingold include Scripps Research Institute & University of Cambridge.
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Journal ArticleDOI
Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses
Dustin Siegel,Hui Hon Chung,Edward Doerffler,Michael O'neil Hanrahan Clarke,Kwon Soo Chun,Lijun Zhang,Sean Neville,Ernest Carra,Willard Lew,Bruce Ross,Queenie Wang,Lydia Wolfe,Robert Jordan,Veronica Soloveva,John E. Knox,Jason K. Perry,Michel Perron,Kirsten M. Stray,Ona Barauskas,Joy Y. Feng,Yili Xu,Gary Lee,Arnold L. Rheingold,Adrian S. Ray,Roy Bannister,Robert G. Strickley,S. Swaminathan,William A. Lee,Sina Bavari,Tomas Cihlar,Michael K. Lo,Travis K. Warren,Richard L. Mackman +32 more
TL;DR: A robust diastereoselective synthesis provided sufficient quantities of 4b to enable preclinical efficacy in a non-human-primate EBOV challenge model and structure activity relationships established that the 1′-CN group and C-linked nucleobase were critical for optimal anti-EBOV potency and selectivity against host polymerases.
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The First Cobalt Single-Molecule Magnet
En-Che Yang,David N. Hendrickson,Wolfgang Wernsdorfer,Motohiro Nakano,Roger D. Sommer,Arnold L. Rheingold,Marisol Ledezma-Gairaud,George Christou +7 more
TL;DR: The first cobalt molecule to function as a single-molecule magnet, [Co4(hmp)4(MeOH)4Cl4], where hmp- is the anion of hydroxymethylpyridine, is reported in this article.
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An Unusual Type of H.cntdot..cntdot..cntdot.H Interaction: Ir-H.cntdot..cntdot..cntdot.H-O and Ir-H.cntdot..cntdot..cntdot.H-N Hydrogen Bonding and Its Involvement in .sigma.-Bond Metathesis
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Monomeric Alkyl and Hydride Derivatives of Zinc Supported by Poly(pyrazoly)hydroborato Ligation: Synthetic, Structural, and Reactivity Studies
Adrian Looney,Runyu Han,Ian B. Gorrell,Mark Cornebise,Keum Yoon,Gerard Parkin,Arnold L. Rheingold +6 more
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Evolution of iridium-based molecular catalysts during water oxidation with ceric ammonium nitrate.
Douglas B. Grotjahn,Derek B. Brown,Jessica K. Martin,David C. Marelius,Marie-Caline Abadjian,Hai N. Tran,Gregory Kalyuzhny,Kenneth S. Vecchio,Zephen G. Specht,Sara A. Cortes-Llamas,Valentín Miranda-Soto,Christoffel van Niekerk,Curtis E. Moore,Arnold L. Rheingold +13 more
TL;DR: Evidence for extensive modification of many Ir-based WOCs even after exposure to only 5 or 15 equiv of Ce(IV) (whereas typically 100-10000 equiv are employed during WOC testing) is provided.