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Asheesh Gupta
Researcher at Harvard University
Publications - 17
Citations - 2799
Asheesh Gupta is an academic researcher from Harvard University. The author has contributed to research in topics: Oxidative stress & Internal medicine. The author has an hindex of 13, co-authored 15 publications receiving 2278 citations. Previous affiliations of Asheesh Gupta include Defence Research and Development Organisation & Defence Institute of Physiology and Allied Sciences.
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Journal ArticleDOI
Antimicrobial strategies centered around reactive oxygen species - bactericidal antibiotics, photodynamic therapy and beyond
Fatma Vatansever,Wanessa C.M.A. de Melo,Wanessa C.M.A. de Melo,Pinar Avci,Pinar Avci,Daniela Vecchio,Magesh Sadasivam,Magesh Sadasivam,Asheesh Gupta,Asheesh Gupta,Rakkiyappan Chandran,Rakkiyappan Chandran,Mahdi Karimi,Mahdi Karimi,Nivaldo Antonio Parizotto,Rui Yin,Rui Yin,George P. Tegos,Michael R. Hamblin,Michael R. Hamblin +19 more
TL;DR: Antioxidant defenses against ROS in microbial cells and the use of ROS by antimicrobial host defense systems are covered and reactive nitrogen species and related therapeutics, such as acidified nitrite and nitric oxide-releasing nanoparticles are covered.
Journal Article
Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring.
Pinar Avci,Asheesh Gupta,Magesh Sadasivam,Daniela Vecchio,Zeev Pam,Nadav Pam,Michael R. Hamblin +6 more
TL;DR: Low-level laser (light) therapy (LLLT) is a fast-growing technology used to treat a multitude of conditions that require stimulation of healing, relief of pain and inflammation, and restoration of function.
Journal ArticleDOI
Blue light for infectious diseases: Propionibacterium acnes, Helicobacter pylori, and beyond?
Tianhong Dai,Asheesh Gupta,Asheesh Gupta,Clinton K. Murray,Mark S. Vrahas,George P. Tegos,George P. Tegos,Michael R. Hamblin,Michael R. Hamblin +8 more
TL;DR: Under certain wavelengths and radiant exposures, blue light may cause cell dysfunction by the photo-excitation of blue light sensitizing chromophores, including flavins and cytochromes, within mitochondria or/and peroxisomes.
Journal ArticleDOI
Light based anti-infectives: ultraviolet C irradiation, photodynamic therapy, blue light, and beyond.
Rui Yin,Tianhong Dai,Pinar Avci,Pinar Avci,Ana Elisa Serafim Jorge,Ana Elisa Serafim Jorge,Wanessa C.M.A. de Melo,Wanessa C.M.A. de Melo,Daniela Vecchio,Ying-Ying Huang,Ying-Ying Huang,Asheesh Gupta,Asheesh Gupta,Michael R. Hamblin,Michael R. Hamblin +14 more
TL;DR: Photodynamic therapy is the combination of non-toxic photosensitizing dyes with harmless visible light that together produce abundant destructive reactive oxygen species (ROS) and has good specificity for binding to microbial cells while sparing host mammalian cells and can be used for treating many localized infections.
Journal ArticleDOI
Blue Light Rescues Mice from Potentially Fatal Pseudomonas aeruginosa Burn Infection: Efficacy, Safety, and Mechanism of Action
Tianhong Dai,Asheesh Gupta,Asheesh Gupta,Ying-Ying Huang,Ying-Ying Huang,Rui Yin,Rui Yin,Clinton K. Murray,Mark S. Vrahas,Margaret E. Sherwood,George P. Tegos,George P. Tegos,Michael R. Hamblin,Michael R. Hamblin +13 more
TL;DR: The efficacy of blue light at 415 nm for the treatment of acute, potentially lethal Pseudomonas aeruginosa burn infections in mice is demonstrated and it is suggested that blue light therapy might offer an effective and safe alternative to conventional antimicrobial therapy for P. aerug inosa burns.