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Astrid Zobel
Researcher at University of Bonn
Publications - 63
Citations - 4996
Astrid Zobel is an academic researcher from University of Bonn. The author has contributed to research in topics: Escitalopram & Nortriptyline. The author has an hindex of 36, co-authored 63 publications receiving 4612 citations.
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Journal ArticleDOI
Genome-Wide Pharmacogenetics of Antidepressant Response in the GENDEP Project
Rudolf Uher,Nader Perroud,Mandy Y.M. Ng,Joanna Hauser,Neven Henigsberg,Wolfgang Maier,Ole Mors,Anna Placentino,Marcella Rietschel,Daniel Souery,Tina Zagar,Piotr M. Czerski,Borut Jerman,Erik Roj Larsen,Thomas G. Schulze,Astrid Zobel,Sarah Cohen-Woods,Katrina Pirlo,Amy W. Butler,Pierandrea Muglia,Michael R. Barnes,Mark Lathrop,Anne Farmer,Gerome Breen,Katherine J. Aitchison,Ian W. Craig,Cathryn M. Lewis,Peter McGuffin +27 more
TL;DR: The results suggest that efficacy of antidepressants may be predicted by genetic markers other than traditional candidates, and genome-wide studies, if properly replicated, may be important steps in the elucidation of the genetic basis of pharmacological response.
Journal ArticleDOI
Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression.
Johannes Schumacher,Rami Abou Jamra,Tim Becker,Stephanie Ohlraun,Norman Klopp,Elisabeth B. Binder,Thomas G. Schulze,Monika Deschner,Christine Schmäl,Susanne Höfels,Astrid Zobel,Thomas Illig,Peter Propping,Florian Holsboer,Marcella Rietschel,Markus M. Nöthen,Markus M. Nöthen,Sven Cichon,Sven Cichon +18 more
TL;DR: The findings suggest that BDNF may be a susceptibility gene for MDD and schizophrenia-in particular, in a subgroup of patients with schizophrenia with a lifetime history of depressive symptoms.
Journal ArticleDOI
Depression symptom dimensions as predictors of antidepressant treatment outcome: replicable evidence for interest-activity symptoms
Rudolf Uher,Roy H. Perlis,Neven Henigsberg,Astrid Zobel,Marcella Rietschel,Ole Mors,Joanna Hauser,Mojca Z. Dernovsek,Daniel Souery,Maja Bajs,Wolfgang Maier,Katherine J. Aitchison,Anne Farmer,Peter McGuffin +13 more
TL;DR: Loss of interest, diminished activity and inability to make decisions predict poor outcome of antidepressant treatment even after adjustment for overall depression severity and other clinical covariates.
Journal ArticleDOI
Measuring depression: Comparison and integration of three scales in the GENDEP study
Rudolf Uher,Anne Farmer,Wolfgang Maier,Marcella Rietschel,Joanna Hauser,Andrej Marusic,Ole Mors,Amanda Elkin,Richard Williamson,Christine Schmael,Neven Henigsberg,Jorge Perez,Julien Mendlewicz,Joost G. E. Janzing,Astrid Zobel,Maria Skibinska,Dejan Kozel,A. S. Stamp,Maja Bajs,Anna Placentino,Mara Isabel Barreto,Peter McGuffin,Katherine J. Aitchison +22 more
TL;DR: The MADRS and the BDI can be recommended as complementary measures of depression severity and the three factor scores are proposed for external validation.
Journal ArticleDOI
Adverse reactions to antidepressants
Rudolf Uher,Anne Farmer,Neven Henigsberg,Marcella Rietschel,Ole Mors,Wolfgang Maier,Dejan Kozel,Joanna Hauser,Daniel Souery,Anna Placentino,Jana Strohmaier,Nader Perroud,Astrid Zobel,Aleksandra Rajewska-Rager,Moica Zvezdana Dernovsek,Erik Roj Larsen,Petra Kalember,Caterina Giovannini,Mara Isabel Barreto,Peter McGuffin,Katherine J. Aitchison +20 more
TL;DR: Most complaints listed as adverse reactions in people with depression were more common when they were medication-free rather than during their treatment with antidepressants, suggesting attention to specific adverse reactions may improve adherence to antidepressant treatment.