M
Mandy Y.M. Ng
Researcher at King's College London
Publications - 30
Citations - 2187
Mandy Y.M. Ng is an academic researcher from King's College London. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 22, co-authored 30 publications receiving 2050 citations. Previous affiliations of Mandy Y.M. Ng include University of London & St Thomas' Hospital.
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Journal ArticleDOI
Genome-Wide Pharmacogenetics of Antidepressant Response in the GENDEP Project
Rudolf Uher,Nader Perroud,Mandy Y.M. Ng,Joanna Hauser,Neven Henigsberg,Wolfgang Maier,Ole Mors,Anna Placentino,Marcella Rietschel,Daniel Souery,Tina Zagar,Piotr M. Czerski,Borut Jerman,Erik Roj Larsen,Thomas G. Schulze,Astrid Zobel,Sarah Cohen-Woods,Katrina Pirlo,Amy W. Butler,Pierandrea Muglia,Michael R. Barnes,Mark Lathrop,Anne Farmer,Gerome Breen,Katherine J. Aitchison,Ian W. Craig,Cathryn M. Lewis,Peter McGuffin +27 more
TL;DR: The results suggest that efficacy of antidepressants may be predicted by genetic markers other than traditional candidates, and genome-wide studies, if properly replicated, may be important steps in the elucidation of the genetic basis of pharmacological response.
Journal ArticleDOI
Meta-analysis of 32 genome-wide linkage studies of schizophrenia
Mandy Y.M. Ng,Douglas F. Levinson,Stephen V. Faraone,Brian K. Suarez,Lynn E. DeLisi,Lynn E. DeLisi,Tadao Arinami,Brien P. Riley,Tiina Paunio,Tiina Paunio,A. E. Pulver,Irmansyah,Peter Holmans,Michael Escamilla,Dieter B. Wildenauer,Nigel Williams,Claudine Laurent,Bryan J. Mowry,Linda M. Brzustowicz,Michel Maziade,Pamela Sklar,D L Garver,Gonçalo R. Abecasis,Bernard Lerer,M D Fallin,Hugh Gurling,Pablo V. Gejman,Eva Lindholm,Hans W. Moises,William Byerley,Ellen M. Wijsman,Paola Forabosco,Ming T. Tsuang,Ming T. Tsuang,H-G Hwu,Yuji Okazaki,Kenneth S. Kendler,Brandon Wormley,Ayman H. Fanous,Ayman H. Fanous,Dermot Walsh,Francis A. O'Neill,Leena Peltonen,Gerald Nestadt,Virginia K. Lasseter,Kung-Yee Liang,G M Papadimitriou,Dimitris Dikeos,Sibylle G. Schwab,Michael John Owen,Michael Conlon O'Donovan,Nadine Norton,Elizabeth Hare,Henriette Raventós,Humberto Nicolini,Margot Albus,Wolfgang Maier,Vishwajit L. Nimgaonkar,Lars Terenius,J. Mallet,Melanie Jay,Stephanie Godard,Deborah A. Nertney,M. Alexander,Raymond R. Crowe,Jeremy M. Silverman,Anne S. Bassett,M-A Roy,Chantal Mérette,Carlos N. Pato,Michele T. Pato,J. Louw Roos,Yoav Kohn,Daniela Amann-Zalcenstein,Gursharan Kalsi,Andrew McQuillin,David Curtis,Jon Brynjolfson,Thordur Sigmundsson,Hannes Petursson,Alan R. Sanders,Jubao Duan,Elena Jazin,Marina Myles-Worsley,Maria Karayiorgou,Cathryn M. Lewis +85 more
TL;DR: The primary analysis met empirical criteria for ‘aggregate’ genome-wide significance, indicating that some or all of 10 bins are likely to contain loci linked to SCZ, including regions of chromosomes 1, 2q, 3q, 4q, 5q, 8p and 10q.
Journal ArticleDOI
Genome-wide association study of major recurrent depression in the U.K. population
Cathryn M. Lewis,Mandy Y.M. Ng,Amy W. Butler,Sarah Cohen-Woods,Rudolf Uher,Katrina Pirlo,Michael E. Weale,Alexandra Schosser,Ursula M. Paredes,Margarita Rivera,Nicholas John Craddock,Michael John Owen,Lisa Jones,Ian Jones,Ania Korszun,Katherine J. Aitchison,Jianxin Shi,John P. Quinn,Alasdair MacKenzie,Peter Vollenweider,Gérard Waeber,Simon Heath,Mark Lathrop,Pierandrea Muglia,Michael R. Barnes,John C. Whittaker,Frederica Tozzi,Florian Holsboer,Martin Preisig,Anne Farmer,Gerome Breen,Ian W. Craig,Peter McGuffin +32 more
TL;DR: This genome-wide association study using 1,636 cases of depression ascertained in the U.K. and comparison subjects screened negative for psychiatric disorders suggests that individual gene contributions to depression are likely to have only minor effects, and very large pooled analyses will be required to identify them.
Journal ArticleDOI
Meta-Analysis of Genome-Wide Scans Provides Evidence for Sex- and Site-Specific Regulation of Bone Mass
John P. A. Ioannidis,John P. A. Ioannidis,John P. A. Ioannidis,Mandy Y.M. Ng,Pak C. Sham,Pak C. Sham,Elias Zintzaras,Cathryn M. Lewis,Hong-Wen Deng,Hong-Wen Deng,Hong-Wen Deng,Michael J. Econs,David Karasik,Marcella Devoto,Candace M. Kammerer,Tim D. Spector,Toby Andrew,L. Adrienne Cupples,Emma L. Duncan,Tatiana Foroud,Douglas P. Kiel,Daniel L. Koller,Bente L. Langdahl,Braxton D. Mitchell,Munro Peacock,Robert R. Recker,Hui Shen,Katia Sol-Church,Loretta D. Spotila,André G. Uitterlinden,Scott Wilson,Annie W.C. Kung,Stuart H. Ralston +32 more
TL;DR: Evidence was gained to suggest that several chromosomal loci regulate BMD in a site‐specific and sex‐specific manner.
Journal ArticleDOI
Genome-wide association study of increasing suicidal ideation during antidepressant treatment in the GENDEP project.
Nader Perroud,Rudolf Uher,Mandy Y.M. Ng,Michel Guipponi,Joanna Hauser,Neven Henigsberg,Wolfgang Maier,Ole Mors,Massimo Gennarelli,Marcella Rietschel,Daniel Souery,Mojca Z. Dernovsek,A. S. Stamp,Mark Lathrop,Anne Farmer,Gerome Breen,Katherine J. Aitchison,Cathryn M. Lewis,Ian W. Craig,Peter McGuffin +19 more
TL;DR: The results suggest novel pathways involved in increasing suicidal ideation during antidepressant treatment and should help to target treatment to reduce the risk of this dramatic adverse event.