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Amy W. Butler
Researcher at King's College London
Publications - 21
Citations - 1714
Amy W. Butler is an academic researcher from King's College London. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 16, co-authored 21 publications receiving 1597 citations. Previous affiliations of Amy W. Butler include Medical Research Council & University of Hong Kong.
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Journal ArticleDOI
Genome-Wide Pharmacogenetics of Antidepressant Response in the GENDEP Project
Rudolf Uher,Nader Perroud,Mandy Y.M. Ng,Joanna Hauser,Neven Henigsberg,Wolfgang Maier,Ole Mors,Anna Placentino,Marcella Rietschel,Daniel Souery,Tina Zagar,Piotr M. Czerski,Borut Jerman,Erik Roj Larsen,Thomas G. Schulze,Astrid Zobel,Sarah Cohen-Woods,Katrina Pirlo,Amy W. Butler,Pierandrea Muglia,Michael R. Barnes,Mark Lathrop,Anne Farmer,Gerome Breen,Katherine J. Aitchison,Ian W. Craig,Cathryn M. Lewis,Peter McGuffin +27 more
TL;DR: The results suggest that efficacy of antidepressants may be predicted by genetic markers other than traditional candidates, and genome-wide studies, if properly replicated, may be important steps in the elucidation of the genetic basis of pharmacological response.
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Genome-wide association study of major recurrent depression in the U.K. population
Cathryn M. Lewis,Mandy Y.M. Ng,Amy W. Butler,Sarah Cohen-Woods,Rudolf Uher,Katrina Pirlo,Michael E. Weale,Alexandra Schosser,Ursula M. Paredes,Margarita Rivera,Nicholas John Craddock,Michael John Owen,Lisa Jones,Ian Jones,Ania Korszun,Katherine J. Aitchison,Jianxin Shi,John P. Quinn,Alasdair MacKenzie,Peter Vollenweider,Gérard Waeber,Simon Heath,Mark Lathrop,Pierandrea Muglia,Michael R. Barnes,John C. Whittaker,Frederica Tozzi,Florian Holsboer,Martin Preisig,Anne Farmer,Gerome Breen,Ian W. Craig,Peter McGuffin +32 more
TL;DR: This genome-wide association study using 1,636 cases of depression ascertained in the U.K. and comparison subjects screened negative for psychiatric disorders suggests that individual gene contributions to depression are likely to have only minor effects, and very large pooled analyses will be required to identify them.
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Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study
Aleksey Shatunov,Kin Y. Mok,Stephen Newhouse,Michael E. Weale,Bradley N. Smith,Caroline Vance,Lauren Johnson,Jan H. Veldink,Michael A van Es,Leonard H. van den Berg,Wim Robberecht,Philip Van Damme,Orla Hardiman,Anne Farmer,Cathryn M. Lewis,Cathryn M. Lewis,Amy W. Butler,Olubunmi Abel,Peter M. Andersen,Isabella Fogh,Vincenzo Silani,Adriano Chiò,Bryan J. Traynor,Judith Melki,Vincent Meininger,John Landers,Peter McGuffin,Jonathan D. Glass,Hardev Pall,P. Nigel Leigh,John Hardy,Robert H. Brown,John Powell,Richard W. Orrell,Karen E. Morrison,Pamela J. Shaw,Christopher Shaw,Ammar Al-Chalabi +37 more
TL;DR: In this paper, the authors found strong evidence of a genetic association of two single nucleotide polymorphisms in a locus on chromosome 9p21.2 with sporadic ALS, in line with previous independent GWAS of ALS and linkage studies of ALS-frontotemporal dementia.
Journal ArticleDOI
ALSOD: the Amyotrophic Lateral Sclerosis Online Database.
TL;DR: The ongoing development and redesign of the ALSOD database and its automated procedures are reported, helping link the mutations of the SOD1 gene to the hypothetical three-dimensional protein structural rearrangement, and the resulting ALS phenotype.
Journal ArticleDOI
Genetic relationships between suicide attempts, suicidal ideation and major psychiatric disorders: A genome-wide association and polygenic scoring study
Niamh Mullins,Nader Perroud,Rudolf Uher,Rudolf Uher,Amy W. Butler,Amy W. Butler,Sarah Cohen-Woods,Margarita Rivera,Margarita Rivera,Karim Malki,Jack Euesden,Robert Power,Katherine E. Tansey,Lisa Jones,Ian Jones,Nicholas John Craddock,Michael John Owen,Ania Korszun,Michael Gill,Ole Mors,Martin Preisig,Wolfgang Maier,Marcella Rietschel,John P. Rice,Bertram Müller-Myhsok,Elisabeth B. Binder,Susanne Lucae,Marcus Ising,Ian W. Craig,Anne Farmer,Peter McGuffin,Gerome Breen,Gerome Breen,Cathryn M. Lewis +33 more
TL;DR: Polygenic score analysis suggests pleiotropy between psychiatric disorders and suicidal ideation whereas the tendency to act on such thoughts may have a partially independent genetic diathesis.