Depression symptom dimensions as predictors of antidepressant treatment outcome: replicable evidence for interest-activity symptoms
Rudolf Uher,Roy H. Perlis,Neven Henigsberg,Astrid Zobel,Marcella Rietschel,Ole Mors,Joanna Hauser,Mojca Z. Dernovsek,Daniel Souery,Maja Bajs,Wolfgang Maier,Katherine J. Aitchison,Anne Farmer,Peter McGuffin +13 more
TLDR
Loss of interest, diminished activity and inability to make decisions predict poor outcome of antidepressant treatment even after adjustment for overall depression severity and other clinical covariates.Abstract:
Background
Symptom dimensions have not yet been comprehensively tested as predictors of the substantial heterogeneity in outcomes of antidepressant treatment in major depressive disorder.read more
Citations
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Depression, stress, and anhedonia: toward a synthesis and integrated model.
TL;DR: A heuristic model is presented postulating that anhedonia arises from dysfunctional interactions between stress and brain reward systems, and a synthesis of these four literatures is provided.
Journal ArticleDOI
Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders
Gin S Malhi,Darryl Bassett,Philip Boyce,Richard A. Bryant,Paul B. Fitzgerald,Kristina Fritz,Malcolm Hopwood,Bill Lyndon,Roger T. Mulder,Greg Murray,Richard J Porter,Ajeet B. Singh +11 more
TL;DR: The Mood Disorder CPG is the first Clinical Practice Guideline to address both depressive and bipolar disorders and provides up-to-date recommendations and guidance within an evidence-based framework, supplemented by expert clinical consensus.
Journal ArticleDOI
Depression is not a consistent syndrome: An investigation of unique symptom patterns in the STAR*D study
Eiko I. Fried,Randolph M. Nesse +1 more
TL;DR: The substantial symptom variation among individuals who all qualify for one diagnosis calls into question the status of MDD as a specific consistent syndrome and offers a potential explanation for the difficulty in documenting treatment efficacy.
Journal ArticleDOI
Depression sum-scores don’t add up: why analyzing specific depression symptoms is essential
Eiko I. Fried,Randolph M. Nesse +1 more
TL;DR: It is suggested that the pervasive use of sum-scores to estimate depression severity has obfuscated crucial insights and contributed to the lack of progress in key research areas such as identifying biomarkers and more efficacious antidepressants.
Journal ArticleDOI
Cross-trial prediction of treatment outcome in depression: a machine learning approach
Adam M Chekroud,Ryan Zotti,Zarrar Shehzad,Ralitza Gueorguieva,Marcia K. Johnson,Madhukar H. Trivedi,Tyrone D. Cannon,John H. Krystal,Philip R. Corlett +8 more
TL;DR: An algorithm to assess whether patients will achieve symptomatic remission from a 12-week course of citalopram is developed and predicted outcomes in the STAR*D cohort with accuracy significantly above chance.
References
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Journal ArticleDOI
An inventory for measuring depression
TL;DR: The difficulties inherent in obtaining consistent and adequate diagnoses for the purposes of research and therapy have been pointed out and a wide variety of psychiatric rating scales have been developed.
Journal ArticleDOI
A new depression scale designed to be sensitive to change.
Stuart Montgomery,Marie Åsberg +1 more
TL;DR: The construction of a depression rating scale designed to be particularly sensitive to treatment effects is described, and its capacity to differentiate between responders and non-responders to antidepressant treatment was better than the HRS, indicating greater sensitivity to change.
Journal ArticleDOI
Development of a Rating Scale for Primary Depressive Illness
TL;DR: This is an account of further work on a rating scale for depressive states, including a detailed discussion on the general problems of comparing successive samples from a ‘population’, the meaning of factor scores, and the other results obtained.
Journal ArticleDOI
Acute and Longer- Term Outcomes in Depressed Outpatients Requiring One or Several Treatment Steps: A STAR*D Report
A. John Rush,Madhukar H. Trivedi,Stephen R. Wisniewski,Andrew A. Nierenberg,Jonathan W. Stewart,Diane Warden,George Niederehe,Michael E. Thase,Philip W. Lavori,Barry D. Lebowitz,Patrick J. McGrath,Jerrold F. Rosenbaum,Harold A. Sackeim,David J. Kupfer,James F. Luther,Maurizio Fava +15 more
TL;DR: The acute and longer-term treatment outcomes associated with each of four successive steps in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial are described and compared.
Journal ArticleDOI
Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice
Madhukar H. Trivedi,A. John Rush,Stephen R. Wisniewski,Andrew A. Nierenberg,Diane Warden,Louise Ritz,Grayson Norquist,Robert H Howland,Barry D. Lebowitz,Patrick J. McGrath,Kathy Shores-Wilson,Melanie M. Biggs,Goundappa K. Balasubramani,Maurizio Fava +13 more
TL;DR: The response and remission rates in this highly generalizable sample with substantial axis I and axis III comorbidity closely resemble those seen in 8-week efficacy trials.