A
Atar Lev
Researcher at Sheba Medical Center
Publications - 82
Citations - 1462
Atar Lev is an academic researcher from Sheba Medical Center. The author has contributed to research in topics: Immunodeficiency & Medicine. The author has an hindex of 17, co-authored 63 publications receiving 1068 citations. Previous affiliations of Atar Lev include Boston Children's Hospital & Bar-Ilan University.
Papers
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Journal ArticleDOI
Timely and spatially regulated maturation of B and T cell repertoire during human fetal development
Erez Rechavi,Atar Lev,Yu Nee Lee,Amos J. Simon,Yoav Yinon,Schlomo Lipitz,Ninette Amariglio,Boaz Weisz,Luigi D. Notarangelo,Luigi D. Notarangelo,Raz Somech +10 more
TL;DR: It is found that B cell development precedes T cell development and that repertoire maturation is both temporally and spatially regulated in the human fetus.
Journal ArticleDOI
A Congenital Neutrophil Defect Syndrome Associated with Mutations in VPS45
Thierry Vilboux,Atar Lev,May Christine V. Malicdan,Amos J. Simon,Päivi M Järvinen,Tomas Racek,Jacek Puchałka,Raman Sood,Blake Carrington,Kevin Bishop,James C. Mullikin,Marjan Huizing,Ben Zion Garty,Eran Eyal,Baruch Wolach,Ronit Gavrieli,Amos Toren,Amos Toren,Michalle Soudack,Michalle Soudack,Osama M. Atawneh,Tatiana Babushkin,Tatiana Babushkin,Ginette Schiby,Ginette Schiby,Andrew R. Cullinane,Camila Avivi,Camila Avivi,Sylvie Polak-Charcon,Sylvie Polak-Charcon,Iris Barshack,Iris Barshack,Ninette Amariglio,Gideon Rechavi,Jutte van der Werff ten Bosch,Yair Anikster,Yair Anikster,Christoph Klein,William A. Gahl,Raz Somech,Raz Somech +40 more
TL;DR: Defective endosomal intracellular protein trafficking due to biallelic mutations in VPS45 underlies a new immunodeficiency syndrome involving impaired neutrophil function.
Journal ArticleDOI
Mutations in STN1 cause Coats plus syndrome and are associated with genomic and telomere defects.
Amos J. Simon,Atar Lev,Yong Zhang,Batia Weiss,Anna Rylova,Eran Eyal,Nitzan Kol,Ortal Barel,Keren Cesarkas,Michalle Soudack,Noa Greenberg-Kushnir,Michele Rhodes,David L. Wiest,Ginette Schiby,Iris Barshack,Shulamit Katz,Elon Pras,Hana Poran,Haike Reznik-Wolf,Elena Ribakovsky,Carlos Simon,Wadi Hazou,Yechezkel Sidi,Avishay Lahad,Hagar Katzir,Shira Sagie,Haifa A. Aqeilan,Galina Glousker,Ninette Amariglio,Yehuda Tzfati,Sara Selig,Gideon Rechavi,Raz Somech +32 more
TL;DR: Two new mutations in STN1 that causes Coats plus syndrome and telomere abnormalities in human, recapitulated in a zebra fish model are identified.
Journal ArticleDOI
Intestinal Inflammation and Dysregulated Immunity in Patients With Inherited Caspase-8 Deficiency.
Anna S. Lehle,Henner F. Farin,Henner F. Farin,Benjamin Marquardt,Birgitta E. Michels,Thomas Magg,Yue Li,Yanshan Liu,Maryam Ghalandary,Katja Lammens,Sebastian Hollizeck,Meino Rohlfs,Fabian Hauck,Raffaele Conca,Christoph Walz,Batia Weiss,Batia Weiss,Atar Lev,Atar Lev,Amos J. Simon,Amos J. Simon,Olaf Groß,Moritz M. Gaidt,Veit Hornung,Hans Clevers,Nadine Yazbeck,Rima Hanna-Wakim,Dror S. Shouval,Dror S. Shouval,Neil Warner,Raz Somech,Raz Somech,Aleixo M. Muise,Scott B. Snapper,Scott B. Snapper,Scott B. Snapper,Philip Bufler,Philip Bufler,Sibylle Koletzko,Christoph Klein,Daniel Kotlarz +40 more
TL;DR: Findings indicate that CASP8 controls inflammation, innate and adaptive immunity, and intestinal barrier integrity in humans.
Journal ArticleDOI
First Year of Israeli Newborn Screening for Severe Combined Immunodeficiency-Clinical Achievements and Insights.
Erez Rechavi,Atar Lev,Amos J. Simon,Tali Stauber,Suha Daas,Talia Saraf-Levy,Arnon Broides,Amit Nahum,Nufar Marcus,Suhair Hanna,Polina Stepensky,Ori Toker,Ilan Dalal,Amos Etzioni,Shlomo Almashanu,Raz Somech,Raz Somech +16 more
TL;DR: A maturational step in T cell development around week 29 gestation is suggested, and moderate to late preterms should be screened with the same cutoff as term infants, as well as the high rate of FPs within this group.