A
Atsushi Enomoto
Researcher at Nagoya University
Publications - 217
Citations - 10876
Atsushi Enomoto is an academic researcher from Nagoya University. The author has contributed to research in topics: Cancer & Organic anion transporter 1. The author has an hindex of 54, co-authored 189 publications receiving 9285 citations. Previous affiliations of Atsushi Enomoto include Laval University & Kyorin University.
Papers
More filters
Journal ArticleDOI
Molecular identification of a renal urate anion exchanger that regulates blood urate levels.
Atsushi Enomoto,Hiroaki Kimura,Hiroaki Kimura,Arthit Chairoungdua,Yasuhiro Shigeta,Yasuhiro Shigeta,Promsuk Jutabha,Seok Ho Cha,Makoto Hosoyamada,Michio Takeda,Takashi Sekine,Takashi Igarashi,Hirotaka Matsuo,Hirotaka Matsuo,Yuichi Kikuchi,Takashi Oda,Kimiyoshi Ichida,Tatsuo Hosoya,Kaoru Shimokata,Toshimitsu Niwa,Yoshikatsu Kanai,Hitoshi Endou +21 more
TL;DR: This work identifies the long-hypothesized urate transporter in the human kidney (URAT1, encoded by SLC22A12), a urate–anion exchanger regulating blood urate levels and targeted by uricosuric and antiuricOSuric agents (which affect excretion of uric acid).
Journal ArticleDOI
Akt/PKB Regulates Actin Organization and Cell Motility via Girdin/APE
Atsushi Enomoto,Hideki Murakami,Naoya Asai,Nobuhiro Morone,Takashi Watanabe,Kumi Kawai,Yoshiki Murakumo,Jiro Usukura,Kozo Kaibuchi,Masahide Takahashi +9 more
TL;DR: This work identifies an Akt substrate, designated Girdin/APE (Akt-phosphorylation enhancer), which is an actin binding protein, which plays a crucial role in the formation of stress fibers and lamellipodia.
Journal ArticleDOI
Clinical and Molecular Analysis of Patients with Renal Hypouricemia in Japan-Influence of URAT1 Gene on Urinary Urate Excretion
Kimiyoshi Ichida,Makoto Hosoyamada,Ichiro Hisatome,Atsushi Enomoto,Miho Hikita,Hitoshi Endou,Tatsuo Hosoya +6 more
TL;DR: The findings indicate that SLC22A12 was responsible for most renal hypouricemia and that URAT1 is the primary reabsorptive urate transporter, targeted by pyrazinamide, benzbromarone, and probenecid in vivo.
Journal ArticleDOI
Cancer-associated fibroblasts in gastrointestinal cancer
Hiroki Kobayashi,Atsushi Enomoto,Susan L. Woods,Alastair D. Burt,Masahide Takahashi,Daniel L. Worthley +5 more
TL;DR: An improved understanding of CAF biology could lead to the development of novel stroma-based diagnostics, prognostics and therapeutics, and the clinical implications of CAFs as biomarkers and potential targets for prevention and treatment of patients with gastrointestinal cancer are discussed.
Journal ArticleDOI
Role of Organic Anion Transporters in the Tubular Transport of Indoxyl Sulfate and the Induction of its Nephrotoxicity
Atsushi Enomoto,Michio Takeda,Akihiro Tojo,Takashi Sekine,Seok Ho Cha,Suparat Khamdang,Fumio Takayama,Isao Aoyama,Sakurako Nakamura,Hitoshi Endou,Toshimitsu Niwa +10 more
TL;DR: This study demonstrates the role of rat organic anion transporters (rOATs) in the transport of IS and the induction of its nephrotoxicity and suggests that rOAT1 and rOat3 play an important role in the transcellular transport ofIS.