Axel Ullrich

TL;DR: It is concluded that GPCR-induced chemotaxis of breast cancer cells is mediated by EGFR-dependent and -independent signalling pathways, with both parallel pathways having to act in concert to achieve a complete migratory response.

TL;DR: The results indicate that the C‐terminal domain of the EGFR is non‐essential in fibroblast transformation, but seems to be crucial for both self renewal induction and specificity of receptor function in erythroblasts.

TL;DR: Investigation of the expression pattern of FGFR4 and the clinical significance of the recently identified Gly/Arg polymorphism in head and neck squamous cell carcinomas (HNSCCs) of the oral cavity and the oropharynx indicates that high expression ofFGFR4 in connection with the Arg388 allele is associated with poor clinical outcome and supports the significance of FG FR4 as a diagnostic marker and a target for therapeutic intervention in human HNSCC.

TL;DR: Kinetic parameters of the kinase of wild‐type and mutant receptors were compared and alterations of individual autophosphorylation sites do not have a major effect on kinase activity.

TL;DR: Although the PDGF and CSF‐1 receptors are structurally related and appear to be derived from a single ancestor gene, only PDGF‐induced mitogenesis in fibroblasts correlated with tyrosine phosphorylation of PLC‐gamma.