Axel Ullrich

TL;DR: A postgenomic wave of sophisticated "smart drugs" to fundamentally change the treatment of all cancers is anticipated, and interest in this new class of therapeutics extends from basic research scientists to practicing oncologists and their patients.

TL;DR: The recent identification of Zn2+-dependent metalloproteinases and transmembrane growth factor precursors as critical elements in GPCR-induced EGFR transactivation pathways has defined new components of a cellular communication network of rapidly increasing complexity.

TL;DR: It is concluded that sorting of internalized receptor for degradation or recycling can occur through spatial segregation within the MVB, and sorting of EGF-R is controlled by tyrosine kinase activity.

TL;DR: A panel of monoclonal antibodies specific to the extracellular portion of the ERBB2 protein was generated and it was suggested that the antitumor antibodies affect both receptor function and host-tumor interactions.

TL;DR: In this article, the authors examined whether the differential activation of MAP kinases forms the basis of the differential response of the cells to the two factors, and they found that the distinct effects of nerve growth factor and epidermal growth factor on PC12 cell differentiation can be explained by differences in the extent and duration of activation of p42 and p44 MAP kinase in response to two factors.