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Axel Ullrich
Researcher at Max Planck Society
Publications - 436
Citations - 63142
Axel Ullrich is an academic researcher from Max Planck Society. The author has contributed to research in topics: Receptor tyrosine kinase & Tyrosine kinase. The author has an hindex of 124, co-authored 436 publications receiving 61445 citations. Previous affiliations of Axel Ullrich include Institute of Molecular and Cell Biology & Agency for Science, Technology and Research.
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Journal ArticleDOI
Definition of signals for neuronal differentiation.
Journal ArticleDOI
Molecular Characterization of a cDNA Encoding Functional Human CLK4 Kinase and Localization to Chromosome 4q35
Jörg Schultz,Tania A. Jones,Peer Bork,Denise Sheer,Stephanie Blencke,Silvia Steyrer,Ursula Wellbrock,Dorian Bevec,Axel Ullrich,Christian Wallasch +9 more
TL;DR: This paper identified, cloned, and recombinantly expressed the human orthologue to the murine CLK4 cDNA and localized it to band q35 on chromosome 4 using fluorescence in situ hybridization.
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One bead, one chemical compound: use of the selectide process for anticancer drug discovery.
Sydney E. Salmon,Kit S. Lam,Stephen Felder,Helen Yeoman,Joseph Schlessinger,Axel Ullrich,Viktor Krchnak,Michael Lebl +7 more
TL;DR: Solution phase screening with dual cleavable libraries is being used for growth inhibition of human tumor cell lines and initial in vitro leads have been identified in each of these areas of anticancer drug discovery.
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The adaptor function of SHP-2 downstream of the prolactin receptor is required for the recruitment of p29, a substrate of SHP-2.
Parham Minoo,Naila Chughtai,Manuela Campiglio,Matthias Stein-Gerlach,Jean Jacques Lebrun,Axel Ullrich,Suhad Ali +6 more
TL;DR: It is demonstrated that prolactin (PRL) stimulation of the PRL-responsive Nb2 cells and T47D cells, a human breast cancer cell line, lead to the complex formation of SHP-2 and growth factor receptor-bound protein-2 (grb2), and a highly phosphorylated, 29-kDa protein (p29) is found, a substrate of SHp-2.
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Identification of Elf-1 and B61 as high affinity ligands for the receptor tyrosine kinase MDK1.
Thomas Ciossek,Axel Ullrich +1 more
TL;DR: Findings implicateMDK1 in patterning processes during early mouse embryogenesis and suggest MDK1 involvement in early organogenesis and midbrain development.