A
Axel Ullrich
Researcher at Max Planck Society
Publications - 436
Citations - 63142
Axel Ullrich is an academic researcher from Max Planck Society. The author has contributed to research in topics: Receptor tyrosine kinase & Tyrosine kinase. The author has an hindex of 124, co-authored 436 publications receiving 61445 citations. Previous affiliations of Axel Ullrich include Institute of Molecular and Cell Biology & Agency for Science, Technology and Research.
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Journal ArticleDOI
Inositol phospho-oligosaccharides from rat fibroblasts and adipocytes stimulate 3-O-methylglucose transport.
Monika Kellerer,F Machicao,Lucia Berti,B Sixt,J. Mushack,E Seffer,L Mosthaf,Axel Ullrich,Hans-Ulrich Häring +8 more
TL;DR: It is suggested that adipocytes and rat1-HIR fibroblasts release IPOs that are able to stimulate glucose transport, that both insulin receptor isoforms (HIR-A and HIR-B) mediate the effect of insulin on IPO release, and that overexpression of insulin receptors increases the basal release of IPOs.
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Localization of the gene for amiloride binding protein on chromosome 7 and RFLP analysis in cystic fibrosis families
Pascal Barbry,Brigitte Simon-Bouy,Marie-Geneviève Mattei,Eric Le Guern,Bartolomé Jaume-Roig,Olivier Chassande,Axel Ullrich,Michel Lazdunski +7 more
TL;DR: It appears that the gene coding for ABP is not directly modified by mutations causing cystic fibrosis, and its activity is blocked by the diuretic amiloride.
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The carboxy terminal 110 amino acid portion of the insulin receptor is important for insulin signalling to pyruvate dehydrogenase
TL;DR: Findings suggest the carboxy terminal portion of the IR may play a role in mediating the stimulation of PDH activity in cells that overexpressed normal human insulin receptors.
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Novel compounds reducing IRS-1 serine phosphorylation for treatment of diabetes.
Laura Simon-Szabó,Márton Kokas,Zoltán Greff,Sándor Boros,Péter Bánhegyi,Lilian Zsákai,Csaba Szántai-Kis,Tibor Vántus,József Mandl,Gábor Bánhegyi,István Vályi-Nagy,László Őrfi,Axel Ullrich,Miklós Csala,György Kéri +14 more
TL;DR: A series of novel pyrido[2,3-d]pyrimidin-7-one derivatives were synthesized as potential antidiabetic agents, preventing IRS-1 phosphorylation at serine 307 in a cellular model of lipotoxicity and type 2 diabetes.
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C-Terminus or Juxtamembrane Deletions in the Insulin Receptor do not Affect the Glucose-Dependent Inhibition of the Tyrosine Kinase Activity
Luitgard Mosthaf,Lucia Berti,Monika Kellerer,J. Mushack,E Seffer,Birgit Bossenmaier,Mathew Coghlan,Kenneth Siddle,Axel Ullrich,Hans-Ulrich Häring +9 more
TL;DR: The data suggest that the regulatory serine or threonine phosphorylation site(s) involved in the inhibitory effect of hyperglycemia are neither located in the C-terminus nor in the juxtamembrane region of the insulin receptor beta subunit.