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Axel Ullrich
Researcher at Max Planck Society
Publications - 436
Citations - 63142
Axel Ullrich is an academic researcher from Max Planck Society. The author has contributed to research in topics: Receptor tyrosine kinase & Tyrosine kinase. The author has an hindex of 124, co-authored 436 publications receiving 61445 citations. Previous affiliations of Axel Ullrich include Institute of Molecular and Cell Biology & Agency for Science, Technology and Research.
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Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure.
TL;DR: Results implicate EGFR in the control of hair cycle progression, and provide new information about its role in epidermal growth and differentiation, in transgenic skin keratinocytes.
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Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation
Ingvar Ferby,Markus Reschke,Oliver Kudlacek,Pjotr Knyazev,Guido Pante,Kerstin Amann,Wolfgang Sommergruber,Norbert Kraut,Axel Ullrich,Reinhard Fässler,Rüdiger Klein +10 more
TL;DR: Deletion of the mouse gene encoding Mig6 is shown to cause hyperactivation of endogenous epidermal growth factor receptor (EGFR) and sustained signaling through the mitogen-activated protein kinase (MAPK) pathway, resulting in overproliferation and impaired differentiation of Epidermal keratinocytes, indicating a tumor-suppressive role for Mig6.
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Structural Basis for Gas6-Axl Signalling.
Takako Sasaki,Pjotr Knyazev,Naomi J Clout,Yuri Cheburkin,Walter Göhring,Axel Ullrich,Rupert Timpl,Erhard Hohenester +7 more
TL;DR: Structural‐based mutagenesis, protein binding assays and receptor activation experiments demonstrate that both the major and minor Gas6 binding sites are required for productive transmembrane signalling.
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Bidirectional negative regulation of human T and dendritic cells by CD47 and its cognate receptor signal-regulator protein-alpha: down-regulation of IL-12 responsiveness and inhibition of dendritic cell activation.
Sylvain Latour,Hiroyuki Tanaka,Christian E. Demeure,Véronique Mateo,Manuel Rubio,Eric J. Brown,Charles R. Maliszewski,Frederik P. Lindberg,Anna Oldenborg,Axel Ullrich,Guy Delespesse,Marika Sarfati +11 more
TL;DR: CD47 on T cells and its cognate receptor SIRP-α on DC define a novel regulatory pathway that may be involved in the maintenance of homeostasis by preventing the escalation of the inflammatory immune response.
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Expression of the p185 encoded by HER2 oncogene in normal and transformed human tissues.
Pier Giorgio Natali,Maria Rita Nicotra,Aldo Bigotti,Irene Venturo,Dennis J. Slamon,Brian M. Fendly,Axel Ullrich +6 more
TL;DR: The findings indicate that the expression of the p185 HER2 represents a tumor marker of clinical relevance in breast cancer, and whether this holds true for other malignancies remains to be explored.