Axel Ullrich

TL;DR: The results suggest distinct roles of RPTPs in cell proliferation and establishing phenotypes of different retinal cells during retinogenesis as well as later in the maintenance of mature retina.

TL;DR: Thinner forms of PTP1B retained the same characteristics as the full-length mammalian enzyme, but are not subject to inhibition of enzymic activity mediated by the C-terminus, and it can be assumed that the catalytic domains are advantageous for crystallization studies in comparison to the natural enzyme.

TL;DR: In this paper, the authors show that selection of NIH 3T3 fibroblasts for resistance to the cytotoxic effects of tumor necrosis factor alpha (TNF-alpha), a major mediator of macrophage-induced tumor cell cytotoxicity, leads to enrichment in the remaining cells for those with transformed morphology and is often associated with amplified copy number and expression of the met protooncogene.

TL;DR: In the retrospective study of 8 NSCLC patients, the administration of metformin did not induce statistically significant changes as assessed by immunohistochemical staining of pERK, pAKT and cleaved PARP.

TL;DR: Application of the synthetic inhibitor of M MP‐3 NNGH and small interfering RNA directed against MMP‐3 reduce mutant E‐cadherin‐enhanced cell motility and point to a functional link between MMP•3 and E‐ cadher in.