A
Axel Ullrich
Researcher at Max Planck Society
Publications - 436
Citations - 63142
Axel Ullrich is an academic researcher from Max Planck Society. The author has contributed to research in topics: Receptor tyrosine kinase & Tyrosine kinase. The author has an hindex of 124, co-authored 436 publications receiving 61445 citations. Previous affiliations of Axel Ullrich include Institute of Molecular and Cell Biology & Agency for Science, Technology and Research.
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Membrane-proximal binding of STAT3 revealed by cancer-associated receptor variants
TL;DR: It is reported that germline mutations in the membrane-proximal region of type I receptors are able to modulate the amplitude of signal transducer and activator of transcription 3 (STAT3) signaling in cells.
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Identification of a transcriptionally active hVH-5 pseudogene on 10q22.2
TL;DR: In this paper, the human homologue of vaccinia virus H1 phosphatase gene clone 5 (hVH-5) was detected in human peripheral tissues as well as in 11 of 14 breast cancer cell lines.
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Pharmacophore and Binding Analysis of Known and Novel B-RAF Kinase Inhibitors
Ferenc Baska,István Szabadkai,Anna Sipos,Nóra Breza,Csaba Szántai-Kis,László Kékesi,Rita Garamvölgyi,Zoltán Nemes,L. Neumann,Robert Torka,Axel Ullrich,György Kéri,Laszlo Orfi +12 more
TL;DR: The main pharmacophore features of the co-crysallized B-RAF inhibitors published in the literature are described, focusing on the binding modes and common structural elements, and the recently developed B- RAF inhibitor family is presented.
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Novel members of quinoline compound family enhance insulin secretion in RIN-5AH beta cells and in rat pancreatic islet microtissue
Zoltan Örfi,F. Waczek,Ferenc Baska,István Szabadkai,Robert Torka,Jana Hartmann,Laszlo Orfi,Axel Ullrich +7 more
TL;DR: It is confirmed that some TKIs possess antidiabetic effects, and a novel compound family developed from the TKI, bosutinib and optimized for the modulation of insulin secretion is presented.
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The Gly385(388)Arg Polymorphism of the FGFR4 Receptor Regulates Hepatic Lipogenesis Under Healthy Diet.
Stefan Z. Lutz,Anita M. Hennige,Andreas Peter,Marketa Kovarova,Charisis Totsikas,Jürgen Machann,Stefan M Kröber,Bianca Sperl,Erwin Schleicher,Fritz Schick,Martin Heni,Axel Ullrich,Hans-Ulrich Häring,Norbert Stefan +13 more
TL;DR: The data indicate that the FGFR4 Arg388(385) allele affects hepatic lipid and glucose metabolism specifically during healthy caloric intake.