[신간의 별자리x] 우리/미술, 그리고 ‘슬픔의 박물관’

J. Appl. Cryst.の発刊に際して

Yuming Yang,†,§ Qiang Zhao,‡,§ Wei Feng,† and Fuyou Li*,† †Department of Chemistry and State Key Laboratory of Molecular Engineering of Polymers and Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, P. R. China ‡Key Laboratory for Organic Electronics and Information Displays (KLOEID) and Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, Nanjing 210046, P. R. China.

Luminescent chemodosimeters for bioimaging.

: The unpolarized absorption and circular dichroism spectra of the fundamental vibrational transitions of the chiral molecule, 4-methyl-2-oxetanone, are calculated ab initio. Harmonic force fields are obtained using Density Functional Theory (DFT), MP2, and SCF methodologies and a 5S4P2D/3S2P (TZ2P) basis set. DFT calculations use the Local Spin Density Approximation (LSDA), BLYP, and Becke3LYP (B3LYP) density functionals. Mid-IR spectra predicted using LSDA, BLYP, and B3LYP force fields are of significantly different quality, the B3LYP force field yielding spectra in clearly superior, and overall excellent, agreement with experiment. The MP2 force field yields spectra in slightly worse agreement with experiment than the B3LYP force field. The SCF force field yields spectra in poor agreement with experiment.The basis set dependence of B3LYP force fields is also explored: the 6-31G* and TZ2P basis sets give very similar results while the 3-21G basis set yields spectra in substantially worse agreements with experiment. jg

Ab initio calculation of vibrational absorption and circular dichroism spectra using density functional force fields

Recently, more than 1000 large intergenic noncoding RNAs (lincRNAs) have been reported. These RNAs are evolutionarily conserved in mammalian genomes and thus presumably function in diverse biological processes. Here, we report the identification of lincRNAs that are regulated by p53. One of these lincRNAs (lincRNA-p21) serves as a repressor in p53-dependent transcriptional responses. Inhibition of lincRNA-p21 affects the expression of hundreds of gene targets enriched for genes normally repressed by p53. The observed transcriptional repression by lincRNA-p21 is mediated through the physical association with hnRNP-K. This interaction is required for proper genomic localization of hnRNP-K at repressed genes and regulation of p53 mediates apoptosis. We propose a model whereby transcription factors activate lincRNAs that serve as key repressors by physically associating with repressive complexes and modulate their localization to sets of previously active genes.

A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response

Safrole oxide inhibits angiogenesis by inducing apoptosis.

A novel endoplasmic reticulum-targeted ratiometric fluorescent probe based on FRET for the detection of SO2 derivatives

A new pyrazoline-based probe was synthesized and the structure was determined by using X-ray diffraction analysis. The probe responds to Cu2+ in aqueous medium in “turn-off” fluorescent manner with selectivity and sensitivity. Furthermore, the probe could be used for real-time tracking of Cu2+ in Hela cells.

A New Pyrazoline-Based Fluorescent Probe for Cu2+ in Live Cells

AIM: To investigate effect of safrole oxide on cell growth and apoptosis induced 
by deprivation of survival factors (fibroblast growth factors, aFGF and bFGF) in 
vascular endothelial cells (VEC).
METHODS: Morphological changes were observed by light microscopy. Cell growth was
determined by MTT (3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium)
method. DNA fragmentation was analyzed by agarose gel electrophoresis and
fluorescence microscopy. Cell cycle distribution was analyzed by flow cytometry
(FCM).
RESULTS: The cells deprived of FGF were exposed to safrole oxide 5-25 mg/L for 24
h. Cells spreading and growth were promoted (P 0.05). When the cells were
treated with safrole oxide 50-100 mg/L, detachment and DNA fragmentation of VEC
were promoted (P<0.01). The cell cycle was blocked at G2-M phase by safrole oxide
100 mg/L.
CONCLUSION: Safrole oxide 10 mg/L inhibited, but 100 mg/L promoted apoptosis of
VEC. Safrole oxide might be an important compound that affects VEC growth and
apoptosis.

Effect of safrole oxide on vascular endothelial cell growth and apoptosis induced by deprivation of fibroblast growth factor.

BACKGROUND AND PURPOSE: Presbycusis is the most common sensory deficit in the aging population. A recent study reported using a DTI-based tractography technique to identify a lack of integrity in a portion of the auditory pathway in patients with presbycusis. The aim of our study was to investigate the white matter pathology of patients with presbycusis by using a voxel-based analysis that is highly sensitive to local intensity changes in DTI data. MATERIALS AND METHODS: Fifteen patients with presbycusis and 14 age- and sex-matched healthy controls were scanned on a 3T scanner. Fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity were obtained from the DTI data. Intergroup statistics were implemented on these measurements, which were transformed to Montreal Neurological Institute coordinates by using a nonrigid image registration method called large deformation diffeomorphic metric mapping. RESULTS: Increased axial diffusivity, radial diffusivity, and mean diffusivity and decreased fractional anisotropy were found near the right-side hearing-related areas in patients with presbycusis. Increased radial diffusivity and mean diffusivity were also found near a language-related area (Broca area) in patients with presbycusis. CONCLUSIONS: Our findings could be important for exploring reliable imaging evidence of presbycusis and could complement an ROI-based approach.

http://www.ajnr.org/content/ajnr/37/11/2110.full.pdf

Bao-Xiang Zhao

Papers

Safrole oxide inhibits angiogenesis by inducing apoptosis.

A novel endoplasmic reticulum-targeted ratiometric fluorescent probe based on FRET for the detection of SO2 derivatives

A New Pyrazoline-Based Fluorescent Probe for Cu2+ in Live Cells

Effect of safrole oxide on vascular endothelial cell growth and apoptosis induced by deprivation of fibroblast growth factor.

DTI Analysis of Presbycusis Using Voxel-Based Analysis