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Barbara U. Schraml
Researcher at Ludwig Maximilian University of Munich
Publications - 43
Citations - 6149
Barbara U. Schraml is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Dendritic cell & Medicine. The author has an hindex of 19, co-authored 34 publications receiving 5116 citations. Previous affiliations of Barbara U. Schraml include London Research Institute & Francis Crick Institute.
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Journal ArticleDOI
Batf3 Deficiency Reveals a Critical Role for CD8α+ Dendritic Cells in Cytotoxic T Cell Immunity
Kai Hildner,Brian T. Edelson,Whitney E. Purtha,Mark S Diamond,Hirokazu Matsushita,Masako Kohyama,Boris Calderon,Barbara U. Schraml,Emil R. Unanue,Michael S. Diamond,Robert D. Schreiber,Theresa L. Murphy,Kenneth M. Murphy +12 more
TL;DR: An important role is suggested for CD8α+ dendritic cells and cross-presentation in responses to viruses and in tumor rejection in Batf3–/– mice.
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Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny
Martin Guilliams,Florent Ginhoux,Claudia Jakubzick,Shalin H. Naik,Nobuyuki Onai,Barbara U. Schraml,Elodie Segura,Roxane Tussiwand,Simon Yona +8 more
TL;DR: This Opinion article suggests that the mononuclear phagocyte system can be classified primarily by their ontogeny and secondarily by their location, function and phenotype, which permits a more robust classification during both steady-state and inflammatory conditions.
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GM-CSF Mouse Bone Marrow Cultures Comprise a Heterogeneous Population of CD11c(+)MHCII(+) Macrophages and Dendritic Cells.
Julie Helft,Jan P. Böttcher,Probir Chakravarty,Santiago Zelenay,Jatta Huotari,Barbara U. Schraml,Delphine Goubau,Caetano Reis e Sousa +7 more
TL;DR: It is demonstrated that CD11c(+)MHCII(+) BMDCs are in fact a heterogeneous group of cells that comprises conventional DCs and monocyte-derived macrophages, and have important implications for the interpretation of a vast array of data obtained with DC culture systems.
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The AP-1 transcription factor Batf controls TH17 differentiation
Barbara U. Schraml,Kai Hildner,Wataru Ise,Wan-Ling Lee,Whitney A.-E. Smith,Ben Solomon,Gurmukh Sahota,Julia Sim,Ryuta Mukasa,Saso Cemerski,Robin D. Hatton,Gary D. Stormo,Casey T. Weaver,John H. Russell,Theresa L. Murphy,Kenneth M. Murphy +15 more
TL;DR: It is shown that Batf is required for the differentiation of IL17-producing T helper (TH17) cells, and it is demonstrated that the AP-1 protein BATF has a critical role in TH17 differentiation.
Journal ArticleDOI
The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells.
Wataru Ise,Masako Kohyama,Masako Kohyama,Barbara U. Schraml,Tingting Zhang,Tingting Zhang,Bjoern Schwer,Bjoern Schwer,Uttiya Basu,Uttiya Basu,Frederick W. Alt,Frederick W. Alt,Jun Tang,Eugene M. Oltz,Theresa L. Murphy,Kenneth M. Murphy,Kenneth M. Murphy +16 more
TL;DR: The mechanism by which BATF controls in vivo class-switch recombination (CSR) is reported, which functions at multiple hierarchical levels in two cell types to globally regulate switched antibody responses in vivo.