B
Bas Teusink
Researcher at VU University Amsterdam
Publications - 208
Citations - 12497
Bas Teusink is an academic researcher from VU University Amsterdam. The author has contributed to research in topics: Metabolic network & Saccharomyces cerevisiae. The author has an hindex of 56, co-authored 193 publications receiving 10872 citations. Previous affiliations of Bas Teusink include University of Amsterdam & Delft University of Technology.
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Journal ArticleDOI
A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations
Léonie M. Raamsdonk,Bas Teusink,David Broadhurst,Nianshu Zhang,Andrew Hayes,Michael C. Walsh,Jan A. Berden,Kevin M. Brindle,Douglas B. Kell,Jem J. Rowland,Hans V. Westerhoff,Karel van Dam,Stephen G. Oliver +12 more
TL;DR: It is demonstrated how the intracellular concentrations of metabolites can reveal phenotypes for proteins active in metabolic regulation, and this approach to functional analysis, using comparative metabolomics, is called FANCY—an abbreviation for functional analysis by co-responses in yeast.
Journal ArticleDOI
Can yeast glycolysis be understood in terms of in vitro kinetics of the constituent enzymes? Testing biochemistry.
Bas Teusink,Jutta Passarge,Corinne A. Reijenga,Eugenia Esgalhado,Coen C. van der Weijden,Mike Schepper,Michael C. Walsh,Barbara M. Bakker,Karel van Dam,Hans V. Westerhoff,Hans V. Westerhoff,Jacky L. Snoep +11 more
TL;DR: The in vivo behavior of yeast glycolysis can be understood in terms of the in vitro kinetic properties of the constituent enzymes in nongrowing, anaerobic, compressed Saccharomyces cerevisiae.
Can yeast glycolysis be understood in terms of in vitro kinetics of the constituent enzymes
Bas Teusink,Passarge J,Reijenga Ka,Eugenia Esgalhado,Van Der Weijden Cc,Schepper M,Michael C. Walsh,Barbara M. Bakker,Van Dam K,Hans V. Westerhoff,Jacky L. Snoep +10 more
Journal ArticleDOI
Shifts in growth strategies reflect tradeoffs in cellular economics
TL;DR: It is shown how the shift in metabolic efficiency originates from a tradeoff between investments in enzyme synthesis and metabolic yields for alternative catabolic pathways, and elucidate how the optimization of growth by natural selection shapes growth strategies.
Journal ArticleDOI
Analysis of Growth of Lactobacillus plantarum WCFS1 on a Complex Medium Using a Genome-scale Metabolic Model
Bas Teusink,Anne Wiersma,Douwe Molenaar,Christof Francke,Willem M. de Vos,Roland J. Siezen,Eddy J. Smid +6 more
TL;DR: These results illustrate how a genome-scale metabolic model and associated constraint-based modeling techniques can be used to analyze the physiology of growth on a complex medium rather than a minimal salts medium.