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Angelique Smit
Researcher at Royal Free London NHS Foundation Trust
Publications - 7
Citations - 676
Angelique Smit is an academic researcher from Royal Free London NHS Foundation Trust. The author has contributed to research in topics: Antibody & T cell. The author has an hindex of 4, co-authored 5 publications receiving 195 citations.
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Journal ArticleDOI
Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first vaccine dose.
Catherine J. Reynolds,Corinna Pade,Joseph M Gibbons,David Butler,Ashley Otter,Katia Menacho,Marianna Fontana,Marianna Fontana,Angelique Smit,Jane E. Sackville-West,Teresa Cutino-Moguel,Mala K. Maini,Benjamin M. Chain,Mahdad Noursadeghi,Tim Brooks,Amanda Semper,Charlotte Manisty,Charlotte Manisty,Thomas A. Treibel,Thomas A. Treibel,James C. Moon,James C. Moon,UK COVIDsortium Investigators,Ana M. Valdes,Ana M. Valdes,Áine McKnight,Daniel M. Altmann,Rosemary J. Boyton +27 more
TL;DR: In this paper, the authors investigated if single dose vaccination, with or without prior infection, confers cross-protective immunity to variants of SARS-CoV-2 vaccine rollout has coincided with the spread of variants of concern.
Journal ArticleDOI
Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure
Catherine J. Reynolds,Corinna Pade,Joseph Gibbons,Diana Munoz Sandoval,George Joy,Nasim Forooghi,Charlotte Manisty,James C. Moon,Rosemary J. Boyton,Hakam Abbass,Aderonke Abiodun,Mashael Alfarih,Zoe Alldis,Daniel M. Altmann,Oliver E. Amin,Mervyn Andiapen,Jessica Artico,João B Augusto,Georgina L Baca,Sasha N. L. Bailey,Anish N Bhuva,Alex Boulter,Ruth Bowles,Olivia V Bracken,Ben O’Brien,Tim Brooks,Natalie Bullock,David Butler,Gabriella Captur,Olivia Carr,Nicola Champion,Carmen Chan,Aneesh Chandran,Tom Coleman,Jorge Couto de Sousa,Xose Couto-Parada,Eleanor Cross,Teresa Cutino-Moguel,Silvia D'Arcangelo,Rhodri H Davies,Brooke Douglas,Cecilia Di Genova,Keenan Dieobi-Anene,Mariana O. Diniz,Ana Gabriela Aguilar Ellis,Karen Feehan,M. Finlay,Marianna Fontana,Sasha Francis,David Gillespie,Derek W. Gilroy,Matt Hamblin,Gabriella Harker,Georgia C. Hemingway,Jacqueline Hewson,Wendy E. Heywood,Lauren M. Hickling,Bethany Hicks,Aroon D. Hingorani,Lee Howes,Ivie Itua,Victor Jardim,Wing-Yiu Jason Lee,Melanie Jensen,Jessica Jones,Meleri Jones,V. S. Kapil,Caoimhe Kelly,H. Kurdi,Jonathan Lambourne,Kai-Min Lin,Siyi Liu,Aaron Lloyd,Sarah Louth,Mala K. Maini,Vineela Mandadapu,Áine McKnight,Katia Menacho,C. Mfuko,Kevin Mills,Sebastian Millward,Oliver Mitchelmore,Christopher William Moon,Sam M. Murray,Mahdad Noursadeghi,Ashley Otter,Susana Palma,Ruth Parker,Kush Patel,Mihaela Pawarova,Steffen E. Petersen,Brian Piniera,Franziska P Pieper,Lisa Rannigan,Alicja Rapala,Amy Richards,Matthew Robathan,Joshua Rosenheim,Cathy Rowe,M Royds,Jane Sackville West,Genine Sambile,Nathalie Schmidt,Hannah Selman,Amanda Semper,Andreas Seraphim,Mihaela Simion,Angelique Smit,Michelle Sugimoto,Leo Swadling,Stephen Taylor,Nigel J. Temperton,Stephen Thomas,George Douglas Thornton,Thomas A. Treibel,Arthur Tucker,A. Varghese,Jessry Veerapen,Mohit Vijayakumar,Time Warner,Sophie Welch,Hannah White,Theresa Wodehouse,Lucinda Wynne,Dan Zahedi,Benjamin M. Chain +125 more
TL;DR: B and T cell immunity against previous variants of concern was enhanced in triple vaccinated individuals, but magnitude of T and B cell responses against B.1.1 .1.529 spike protein was reduced.
Journal ArticleDOI
Discordant neutralizing antibody and T cell responses in asymptomatic and mild SARS-CoV-2 infection.
Catherine J. Reynolds,Leo Swadling,Joseph M Gibbons,Corinna Pade,Melanie Jensen,Mariana O. Diniz,Nathalie M. Schmidt,David Butler,Oliver E. Amin,Sasha N. L. Bailey,Sam M. Murray,Franziska P Pieper,Stephen Taylor,Jessica Jones,Meleri Jones,Wing-Yiu Jason Lee,Joshua Rosenheim,Aneesh Chandran,George Joy,Cecilia Di Genova,Nigel J. Temperton,Jonathan Lambourne,Teresa Cutino-Moguel,Mervyn Andiapen,Marianna Fontana,Angelique Smit,Amanda Semper,Ben O’Brien,Ben O’Brien,Ben O’Brien,Benjamin M. Chain,Tim Brooks,Charlotte Manisty,Charlotte Manisty,Thomas A. Treibel,Thomas A. Treibel,James C. Moon,James C. Moon,COVIDsortium Investigators,Mahdad Noursadeghi,Daniel M. Altmann,Mala K. Maini,Áine McKnight,Rosemary J. Boyton +43 more
TL;DR: In this paper, the authors analyzed T cell and neutralizing antibody responses in 136 healthcare workers (HCW) 16-18 weeks after United Kingdom lockdown, 76 of whom had mild/asymptomatic SARS-CoV-2 infection captured by serial sampling.
Journal ArticleDOI
Blood transcriptional biomarkers of acute viral infection for detection of pre-symptomatic SARS-CoV-2 infection: a nested, case-control diagnostic accuracy study.
Rishi K Gupta,Joshua Rosenheim,Lucy C K Bell,Aneesh Chandran,José Afonso Guerra-Assunção,Gabriele Pollara,Matthew Whelan,Jessica Artico,George Joy,Hibba Kurdi,Daniel M. Altmann,Rosemary J. Boyton,Mala K. Maini,Áine McKnight,Jonathan Lambourne,Teresa Cutino-Moguel,Charlotte Manisty,Charlotte Manisty,Thomas A. Treibel,Thomas A. Treibel,James C. Moon,James C. Moon,Benjamin M. Chain,Mahdad Noursadeghi,Hakam Abbass,Aderonke Abiodun,Mashael Alfarih,Zoe Alldis,Oliver E. Amin,Mervyn Andiapen,João B Augusto,Georgiana L Baca,Sasha N. L. Bailey,Anish N Bhuva,Alex Boulter,Ruth Bowles,Olivia V Bracken,Ben O’Brien,Tim Brooks,Natalie Bullock,David Butler,Gabriella Captur,Nicola Champion,Carmen Chan,David Collier,Jorge Couto de Sousa,Xose Couto-Parada,Rhodri H Davies,Brooke Douglas,Cecilia Di Genova,Keenan Dieobi-Anene,Mariana O. Diniz,Anaya Ellis,Karen Feehan,Malcolm Finlay,Marianna Fontana,Nasim Forooghi,Celia Gaier,Joseph M Gibbons,Derek W. Gilroy,Matt Hamblin,Gabrielle Harker,Jacqueline Hewson,Lauren M Hickling,Aroon D. Hingorani,Lee Howes,Alun D. Hughes,Gemma Hughes,Rebecca Hughes,Ivie Itua,Victor Jardim,Wing-Yiu Jason Lee,Melaniepetra Jensen,Jessica Jones,Meleri Jones,Vikas Kapil,Kai-Min Lin,Sarah Louth,Vineela Mandadapu,Katia Menacho,Celina Mfuko,Oliver Mitchelmore,Christopher William Moon,Diana Munoz Sandoval,Sam M. Murray,Ashley Otter,Corinna Pade,Susana Palma,Ruth M. Parker,Kush Patel,Babita Pawarova,Steffen E. Petersen,Brian Piniera,Franziska P Pieper,Daniel Pope,Maria Prossora,Lisa Rannigan,Alicja Rapala,Catherine J. Reynolds,Amy Richards,Matthew Robathan,Genine Sambile,Nathalie M. Schmidt,Amanda Semper,Andreas Seraphim,Mihaela Simion,Angelique Smit,Michelle Sugimoto,Leo Swadling,Stephen Taylor,Nigel J. Temperton,Stephen B. Thomas,George Thornton,Art Tucker,Jessry Veerapen,Mohit Vijayakumar,Sophie Welch,Theresa Wodehouse,Lucinda Wynne,Dan Zahedi +119 more
TL;DR: In this paper, a nested case-control diagnostic accuracy study among a prospective cohort of health-care workers undergoing weekly blood and nasopharyngeal swab sampling for whole-blood RNA sequencing and SARS-CoV-2 PCR testing, when fit to attend work, was conducted.
Journal ArticleDOI
Neprilysin inhibition for pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled, proof-of-concept trial.
Adrian J. Hobbs,Amie J Moyes,Reshma S. Baliga,Dipa Ghedia,Rachel Ochiel,Yvonne Sylvestre,Caroline J Doré,Kashfia Chowdhury,Kate Maclagan,Harriet L. Quartly,Reecha Sofat,Angelique Smit,Benjamin E. Schreiber,Gerry Coghlan,Raymond J. MacAllister +14 more
TL;DR: A randomized, double‐blind, placebo‐controlled trial is conducted to assess the efficacy and safety of repurposing the neprilysin inhibitor, racecadotril, in PAH.