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Benjamin Meder
Researcher at Heidelberg University
Publications - 226
Citations - 9623
Benjamin Meder is an academic researcher from Heidelberg University. The author has contributed to research in topics: Dilated cardiomyopathy & Medicine. The author has an hindex of 49, co-authored 198 publications receiving 7530 citations. Previous affiliations of Benjamin Meder include University Hospital Heidelberg & Stanford University.
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Abstract 17517: Genetics of Left Ventricular Noncompaction Cardiomyopathy
Jan Haas,Zhu Feng,Christian Geier,Regina Pribe-Wolferts,Karen S. Frese,Elham Kayvanpour,Farbod Sedaghat-Hamedani,Barbara Peil,Justo Lorenzo Bermejo,Jennifer Franke,Andreas Keller,Yuhua Liao,Hugo A. Katus,Benjamin Meder +13 more
TL;DR: It is shown that LVNC has a substantial genetic component and new candidate genes for a functional dissection of their contribution to cardiac development and as potential therapeutic target are suggested.
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Genotype Complements the Phenotype: Identification of the Pathogenicity of an LMNA Splice Variant by Nanopore Long-Read Sequencing in a Large DCM Family
Farbod Sedaghat-Hamedani,Sabine Rebs,Elham Kayvanpour,Chenchen Zhu,Ali Amr,Marion Müller,Jan Haas,Jingyan Wu,Lars M. Steinmetz,Philipp Ehlermann,Katrin Streckfuss-Bömeke,Norbert Frey,Benjamin Meder +12 more
TL;DR: A combination of NGS, human-induced pluripotent-stem-cell-derived cardiomyocytes (iPSC-CMs) and nanopore long-read sequencing is used to identify the causal variant in a multi-generational pedigree of DCM and reveals the biological significance of the variant c.356+1G>A, which generates a novel 5′ splice site in exon 1 of the cardiac isomer of LMNA.
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NIMA-related kinase 9 regulates the phosphorylation of the essential myosin light chain in the heart
Marion Müller,Rose Eghbalian,Jes Niels Boeckel,Karen S. Frese,Jan Haas,Elham Kayvanpour,Farbod Sedaghat-Hamedani,Maximilian K. Lackner,Oguz Firat Tugrul,Thomas Ruppert,Rewati Tappu,Diana Martins Bordalo,Jasmin M Kneuer,Annika Piekarek,Sabine Herch,Sarah Schudy,Andreas Keller,Nadja Grammes,C. Bischof,Anna Klinke,Margarida Cardoso-Moreira,Henrik Kaessmann,Hugo A. Katus,Norbert Frey,Lars M. Steinmetz,Benjamin Meder +25 more
TL;DR: In this paper , the authors investigated the posttranslational modification of human essential myosin light chain (ELC) and identified NIMA-related kinase 9 (NEK9) to interact with ELC.
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eCardiology: ein strukturierter Ansatz zur Förderung der digitalen Transformation in der Kardiologie
Benjamin Meder,David Duncker,Thomas M. Helms,David M. Leistner,F. Goss,Christian Perings,Victoria Johnson,Anne Freund,Christoph Reich,Jakob Ledwoch,Annette Rahm,Barbara Ruth Milles,Stefan Perings,Janine Pöss,Christoph Dieterich,Eckart Fleck,P Breitbart,Jochen Dutzmann,Gerhard-Paul Diller,Holger Thiele,Norbert Frey,Hugo A. Katus,Peter W. Radke +22 more
TL;DR: In this article , the DGK erkennt die enormen Herausforderungen und das Potenzial der digitalen Medizin, die Prognose kardiovaskulärer Erkrankungen zu verbessern.
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Indirect epigenetic testing identifies a diagnostic signature of cardiomyocyte DNA methylation in heart failure
Christian U. Oeing,Mark E Pepin,Kerstin B. Saul,A Seyhan Agircan,Yassen Assenov,Tobias Merkel,Farbod Sedaghat-Hamedani,Tanja Weis,Benjamin Meder,Kaomei Guan,Christoph Plass,Dieter Weichenhan,Dominik Siede,Johannes Backs +13 more
TL;DR: In this article , the authors determined whether patient plasma confers indirect phenotypic, transcriptional, and/or epigenetic alterations to ex vivo cardiomyocytes to mirror the failing human myocardium.