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Benjamin Meder
Researcher at Heidelberg University
Publications - 226
Citations - 9623
Benjamin Meder is an academic researcher from Heidelberg University. The author has contributed to research in topics: Dilated cardiomyopathy & Medicine. The author has an hindex of 49, co-authored 198 publications receiving 7530 citations. Previous affiliations of Benjamin Meder include University Hospital Heidelberg & Stanford University.
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Journal ArticleDOI
Non-coding RNAs in cardiovascular diseases: diagnostic and therapeutic perspectives.
Wolfgang Poller,Stefanie Dimmeler,Stephane Heymans,Tanja Zeller,Jan Haas,Mahir Karakas,David-Manuel Leistner,Philipp Jakob,Shinichi Nakagawa,Stefan Blankenberg,Stefan Engelhardt,Thomas Thum,Christian Weber,Benjamin Meder,Roger J. Hajjar,Ulf Landmesser +15 more
TL;DR: An update on recent developments and perspectives for diagnostic and therapeutic use of ncRNAs in cardiovascular diseases, including atherosclerosis/coronary disease, post-myocardial infarction remodelling, and heart failure is provided.
Journal ArticleDOI
MicroRNA signatures in total peripheral blood as novel biomarkers for acute myocardial infarction
Benjamin Meder,Andreas Keller,Britta Vogel,Jan Haas,Farbod Sedaghat-Hamedani,Elham Kayvanpour,Steffen Just,Anne Borries,Jessica Rudloff,Petra Leidinger,Eckart Meese,Hugo A. Katus,Wolfgang Rottbauer,Wolfgang Rottbauer +13 more
TL;DR: This study assessed here for the first time whole-genome miRNA expression in peripheral total blood samples of patients with acute myocardial infarction and identified 121 miRNAs, which are significantly dysregulated in AMI patients in comparison to healthy controls.
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Assessment of myocardial deformation with cardiac magnetic resonance strain imaging improves risk stratification in patients with dilated cardiomyopathy
Sebastian J. Buss,Kristin Breuninger,Stephanie Lehrke,Andreas Voss,Christian Galuschky,Dirk Lossnitzer,Florian Andre,Philipp Ehlermann,Jennifer Franke,Tobias Taeger,Lutz Frankenstein,Henning Steen,Benjamin Meder,Evangelos Giannitsis,Hugo A. Katus,Grigorios Korosoglou +15 more
TL;DR: LV longitudinal strain assessed with CMR is an independent predictor of survival in DCM and offers incremental information for risk stratification beyond clinical parameters, biomarker, and standard CMR.
Journal ArticleDOI
Alterations in cardiac DNA methylation in human dilated cardiomyopathy
Jan Haas,Karen S. Frese,Yoon Jung Park,Yoon Jung Park,Andreas Keller,Britta Vogel,Anders Lindroth,Dieter Weichenhan,Jennifer Franke,Simon Fischer,Andrea S. Bauer,Sabine Marquart,Farbod Sedaghat-Hamedani,Elham Kayvanpour,Doreen Köhler,Nadine M. Wolf,Sarah Hassel,Rouven Nietsch,Thomas Wieland,Philipp Ehlermann,Jobst Hendrik Schultz,Andreas Dösch,Derliz Mereles,Stefan E. Hardt,Johannes Backs,Jörg D. Hoheisel,Christoph Plass,Christoph Plass,Hugo A. Katus,Benjamin Meder +29 more
TL;DR: DNA methylation differences in pathways related to heart disease, but also in genes with yet unknown function in DCM or heart failure are detected, namely Lymphocyte antigen 75 (LY75), Tyrosine kinase‐type cell surface receptor HER3 (ERBB3), Homeobox B13 (HOXB13) and Adenosine receptor A2A (ADORA2A).
Journal ArticleDOI
Nexilin mutations destabilize cardiac Z-disks and lead to dilated cardiomyopathy
David Hassel,Tillman Dahme,Jeanette Erdmann,Benjamin Meder,Andreas Huge,Monika Stoll,Steffen Just,Alexander Hess,Philipp Ehlermann,Dieter Weichenhan,Matthias Grimmler,Henrike Liptau,Roland Hetzer,Vera Regitz-Zagrosek,Christine Fischer,Peter Nürnberg,Heribert Schunkert,Hugo A. Katus,Wolfgang Rottbauer +18 more
TL;DR: expression in zebrafish of nexilin proteins encoded by NEXN mutant alleles induced Z-disk damage and heart failure, demonstrating a dominant-negative effect and confirming the disease-causing nature of these mutations.