T
Tanja Weis
Researcher at Heidelberg University
Publications - 33
Citations - 1260
Tanja Weis is an academic researcher from Heidelberg University. The author has contributed to research in topics: Heart failure & Atrial fibrillation. The author has an hindex of 13, co-authored 31 publications receiving 981 citations. Previous affiliations of Tanja Weis include University Hospital Heidelberg.
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Journal ArticleDOI
Atlas of the clinical genetics of human dilated cardiomyopathy
Jan Haas,Karen S. Frese,Barbara Peil,Wanda Kloos,Andreas Keller,Rouven Nietsch,Zhu Feng,Sabine Müller,Elham Kayvanpour,Britta Vogel,Farbod Sedaghat-Hamedani,Wei Keat Lim,Xiaohong Zhao,Dmitriy Fradkin,Doreen Köhler,Simon Fischer,Jennifer Franke,Sabine Marquart,Ioana Barb,Daniel Tian Li,Ali Amr,Philipp Ehlermann,Derliz Mereles,Tanja Weis,Sarah Hassel,Andreas Kremer,Vanessa King,Emil Wirsz,Emil Wirsz,Richard Isnard,Michel Komajda,Alessandra Serio,Maurizia Grasso,Petros Syrris,Eleanor Wicks,Vincent Plagnol,Luis R. Lopes,Tenna Gadgaard,Hans Eiskjær,Mads E. Jørgensen,Diego García-Giustiniani,Martin Ortiz-Genga,María G. Crespo-Leiro,Rondal H Lekanne Dit Deprez,Imke Christiaans,Ingrid A.W. van Rijsingen,Arthur A.M. Wilde,Anders Waldenström,Martino Bolognesi,Riccardo Bellazzi,Stellan Mörner,Justo Lorenzo Bermejo,Lorenzo Monserrat,Eric Villard,Jens Mogensen,Yigal M. Pinto,Philippe Charron,Perry M. Elliott,Eloisa Arbustini,Hugo A. Katus,Benjamin Meder +60 more
TL;DR: This is to the authors' knowledge, the first study that comprehensively investigated the genetics of DCM in a large-scale cohort and across a broad gene panel of the known DCM genes and underline the high analytical quality and feasibility of Next-Generation Sequencing in clinical genetic diagnostics.
Journal ArticleDOI
A genome-wide association study identifies 6p21 as novel risk locus for dilated cardiomyopathy
Benjamin Meder,Frank Rühle,Tanja Weis,Georg Homuth,Andreas Keller,Jennifer Franke,Barbara Peil,Justo Lorenzo Bermejo,Karen S. Frese,Andreas Huge,Anika Witten,Britta Vogel,Jan Haas,Uwe Völker,Florian Ernst,Alexander Teumer,Philipp Ehlermann,Christian Zugck,Frauke Friedrichs,Heyo K. Kroemer,Marcus Dörr,Wolfgang Hoffmann,Bernhard Maisch,Sabine Pankuweit,Volker Ruppert,Thomas Scheffold,Uwe Kühl,H.P. Schultheiss,Reinhold Kreutz,Georg Ertl,Christiane E. Angermann,Philippe Charron,Eric Villard,Françoise Gary,Richard Isnard,Michel Komajda,Matthias Lutz,Thomas Meitinger,Moritz F. Sinner,Moritz F. Sinner,Moritz F. Sinner,H.-Erich Wichmann,Michael Krawczak,Boris Ivandic,Dieter Weichenhan,Goetz Gelbrich,Nour Eddine El-Mokhtari,Stefan Schreiber,Stephan B. Felix,Gerd Hasenfuß,Arne Pfeufer,Norbert Hubner,Stefan Kääb,Eloisa Arbustini,Wolfgang Rottbauer,Wolfgang Rottbauer,Norbert Frey,Norbert Frey,Monika Stoll,Hugo A. Katus +59 more
TL;DR: The present study reveals a novel genetic susceptibility locus that clearly underlines the role of genetically driven, inflammatory processes in the pathogenesis of idiopathic DCM.
Journal ArticleDOI
Epigenome-Wide Association Study Identifies Cardiac Gene Patterning and a Novel Class of Biomarkers for Heart Failure.
Benjamin Meder,Jan Haas,Farbod Sedaghat-Hamedani,Elham Kayvanpour,Karen S. Frese,Alan Lai,Rouven Nietsch,Christina Scheiner,Stefan Mester,Diana Martins Bordalo,Ali Amr,Carsten Dietrich,Dietmar Pils,Dominik Siede,Hauke Hund,Andrea S. Bauer,Daniel B. Holzer,Arjang Ruhparwar,Matthias Mueller-Hennessen,Dieter Weichenhan,Christoph Plass,Tanja Weis,Johannes Backs,Maximilian Wuerstle,Andreas Keller,Hugo A. Katus,Andreas E. Posch +26 more
TL;DR: This first epigenome-wide association study in living patients with heart failure using a multi-omics approach links a subset of 517 epigenetic loci with dilated cardiomyopathy and cardiac gene expression and identifies distinct epigenetic methylation patterns that are conserved across tissues.
Journal ArticleDOI
Gene Polymorphism but not Catalytic Activity of Angiotensin I–Converting Enzyme Is Associated With Coronary Artery Disease and Myocardial Infarction in Low-Risk Patients
Andreas Gardemann,Tanja Weis,Oliver Schwartz,Andreas Eberbach,Norbert Katz,Friedrich Wilhelm Hehrlein,Harald Tillmanns,W. Waas,Werner Haberbosch +8 more
TL;DR: In the total population and in all CAD and MI groups, a strong association was observed between the gene polymorphism and ACE activities; DD genotypes had approximately twofold higher ACE activities than II genotypes; an association of the DD genotype with CAD was found.
Journal ArticleDOI
A new metabolomic signature in type-2 diabetes mellitus and its pathophysiology.
Inken Padberg,Erik Peter,Sandra González-Maldonado,Henning Witt,Matthias Mueller,Tanja Weis,Bianca Bethan,Volker Liebenberg,Jan C. Wiemer,Hugo A. Katus,Dietrich Rein,Philipp Schatz +11 more
TL;DR: A metabolic signature including glyoxylate was associated with type-2 diabetes mellitus, independent of the fasting status and of occurrence of another major disease.