B
Benjamin Meder
Researcher at Heidelberg University
Publications - 226
Citations - 9623
Benjamin Meder is an academic researcher from Heidelberg University. The author has contributed to research in topics: Dilated cardiomyopathy & Medicine. The author has an hindex of 49, co-authored 198 publications receiving 7530 citations. Previous affiliations of Benjamin Meder include University Hospital Heidelberg & Stanford University.
Papers
More filters
Journal ArticleDOI
Identification of circular RNAs with host gene-independent expression in human model systems for cardiac differentiation and disease
Dominik Siede,K. Rapti,Agnieszka A. Gorska,Hugo A. Katus,Janine Altmüller,Jes-Niels Boeckel,Benjamin Meder,Benjamin Meder,Christoph Maack,Mirko Völkers,Oliver J. Müller,Oliver J. Müller,Johannes Backs,Christoph Dieterich,Christoph Dieterich +14 more
TL;DR: The hiPSC-CM model uncovered a new signature of potentially disease relevant circRNAs which may serve as novel therapeutic targets and may interact with the ribosome and RISC complex.
Journal ArticleDOI
Mavacamten Favorably Impacts Cardiac Structure in Obstructive Hypertrophic Cardiomyopathy: EXPLORER-HCM Cardiac Magnetic Resonance Substudy Analysis.
Sara Saberi,N. Cardim,Mohamad H. Yamani,Jeanette Schulz-Menger,Wanying Li,Victoria Florea,Amy J. Sehnert,Raymond Y. Kwong,Michael Jerosch-Herold,Ahmad Masri,Anjali T. Owens,Neal K. Lakdawala,Christopher M. Kramer,Mark V. Sherrid,Tim Seidler,Andrew Wang,Farbod Sedaghat-Hamedani,Benjamin Meder,Ofer Havakuk,Daniel Jacoby +19 more
TL;DR: Sara Saberi, MD Nuno Cardim, MD Mohamad Yamani, MD Jeanette Schulz-Menger Wanying Li, PhD Victoria Florea, MD Amy J. Kwong, MD, MPH Michael Jerosch-Herold, PhD Ahmad Masri, MD Anjali Owens, MD Neal K. Lakdawala, MD
Journal ArticleDOI
A proteolytic fragment of histone deacetylase 4 protects the heart from failure by regulating the hexosamine biosynthetic pathway
Lorenz H. Lehmann,Zegeye H Jebessa,Michael M. Kreusser,Axel Horsch,Tao He,Mariya Kronlage,Matthias Dewenter,Viviana Sramek,Ulrike Oehl,Jutta Krebs-Haupenthal,Albert von der Lieth,Andrea Schmidt,Qiang Sun,Julia Ritterhoff,Daniel Finke,Mirko Völkers,Andreas Jungmann,Sven W. Sauer,Christian Thiel,Alexander Nickel,Michael Kohlhaas,Michaela Schäfer,Carsten Sticht,Christoph Maack,Norbert Gretz,Michael Wagner,Ali El-Armouche,Lars S. Maier,Juan E. Camacho Londoño,Benjamin Meder,Marc Freichel,Hermann Josef Gröne,Patrick Most,Oliver J. Müller,Stephan Herzig,Eileen E. M. Furlong,Hugo A. Katus,Johannes Backs +37 more
TL;DR: A new regulatory axis in which epigenetic regulation of a metabolic pathway affects calcium handling is described, Activation of this axis during intermittent physiological stress promotes cardiac function, whereas its impairment in sustained pathological cardiac stress leads to heart failure.
Journal ArticleDOI
Influence of the Confounding Factors Age and Sex on MicroRNA Profiles from Peripheral Blood
Benjamin Meder,Benjamin Meder,Christina Backes,Jan Haas,Petra Leidinger,Cord F. Stähler,Thomas Großmann,Britta Vogel,Karen S. Frese,Evangelos Giannitsis,Hugo A. Katus,Hugo A. Katus,Eckart Meese,Andreas Keller +13 more
TL;DR: The age distribution of individuals recruited for case-control studies needs to be carefully considered, whereas sex may be less confounding, to support the translation of miRNAs into clinical application.
Journal ArticleDOI
Regional Variation in RBM20 Causes a Highly Penetrant Arrhythmogenic Cardiomyopathy
Victoria N. Parikh,Colleen Caleshu,Chloe M. Reuter,Laura C. Lazzeroni,Jodie Ingles,John Garcia,Kristen McCaleb,Tolulope Adesiyun,Farbod Sedaghat-Hamedani,Saurabh Kumar,Sharon L. Graw,Marta Gigli,Davide Stolfo,Matteo Dal Ferro,Alexander Y Ing,Robert L. Nussbaum,Birgit Funke,Matthew T. Wheeler,Ray E. Hershberger,Stuart A. Cook,Lars M. Steinmetz,Neal K. Lakdawala,Matthew R.G. Taylor,Luisa Mestroni,Marco Merlo,Gianfranco Sinagra,Christopher Semsarian,Benjamin Meder,Benjamin Meder,Daniel P. Judge,Euan A. Ashley +30 more
TL;DR: These findings underline the importance of arrhythmia surveillance and family screening in this disease and represent the first step in defining the genetic architecture of RBM20 disease causality on a population level.