B
Bernhard Kuster
Researcher at Technische Universität München
Publications - 310
Citations - 37543
Bernhard Kuster is an academic researcher from Technische Universität München. The author has contributed to research in topics: Proteome & Proteomics. The author has an hindex of 79, co-authored 277 publications receiving 31872 citations. Previous affiliations of Bernhard Kuster include GlaxoSmithKline & German Cancer Research Center.
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Journal ArticleDOI
18O-labeling of N-glycosylation sites to improve the identification of gel-separated glycoproteins using peptide mass mapping and database searching.
Bernhard Kuster,Matthias Mann +1 more
TL;DR: It is demonstrated that enzymatic removal of N-linked glycans with simultaneous partial (50%) 18O-labeling of glycosylated asparagine residues prior to proteolysis and MALDI peptide mass mapping can overcome problems and increase the specificity of subsequent database searches.
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Proteome wide purification and identification of O-GlcNAc-modified proteins using click chemistry and mass spectrometry.
Hannes Hahne,Nadine Sobotzki,Tamara Nyberg,Dominic Helm,Vladimir S. Borodkin,Daan M. F. van Aalten,Brian Agnew,Bernhard Kuster,Bernhard Kuster +8 more
TL;DR: A significantly improved O-GlcNAc protein enrichment procedure is demonstrated, which exploits metabolic labeling of cells by azide-modified Glc NAc and copper-mediated Click chemistry for purification of modified proteins on an alkyne-resin.
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The emerging landscape of single-molecule protein sequencing technologies
Javier A. Alfaro,Peggy R. Bohländer,Mingjie Dai,Mike Filius,Cecil J Howard,Xander F. van Kooten,Shilo Ohayon,Adam Pomorski,Sonja Schmid,Aleksei Aksimentiev,Eric V. Anslyn,Georges Bedran,Chan Cao,Mauro Chinappi,Etienne Coyaud,Cees Dekker,Gunnar Dittmar,Nicholas Drachman,Rienk Eelkema,David R. Goodlett,David R. Goodlett,Sebastien Hentz,Umesh Kalathiya,Neil L. Kelleher,Ryan T. Kelly,Zvi Kelman,Sung Hyun Kim,Bernhard Kuster,David Rodriguez-Larrea,Stuart Lindsay,Giovanni Maglia,Edward M. Marcotte,John P. Marino,Christophe Masselon,Michael Mayer,Patroklos Samaras,Kumar Sarthak,Lusia Sepiashvili,Derek Stein,Meni Wanunu,Mathias Wilhelm,Peng Yin,Amit Meller,Chirlmin Joo +43 more
TL;DR: In this paper, the authors describe new single-molecule protein sequencing and identification technologies alongside innovations in mass spectrometry that will eventually enable broad sequence coverage in single-cell profiling.
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Immunomodulatory drugs disrupt the cereblon-CD147-MCT1 axis to exert antitumor activity and teratogenicity
Ruth Eichner,Michael Heider,Vanesa Fernández-Sáiz,Vanesa Fernández-Sáiz,Frauke van Bebber,Anne-Kathrin Garz,Anne-Kathrin Garz,Simone Lemeer,Martina Rudelius,Bianca-Sabrina Targosz,Laura Jacobs,Anna-Maria Knorn,Jolanta Slawska,Uwe Platzbecker,Ulrich Germing,Christian Langer,Stefan Knop,H. Einsele,Christian Peschel,Christian Peschel,Christian Haass,Christian Haass,Ulrich Keller,Ulrich Keller,Bettina Schmid,Katharina Götze,Katharina Götze,Bernhard Kuster,Florian Bassermann,Florian Bassermann +29 more
TL;DR: It is found that IMiDs outcompete CRBN for binding to CD147 and MCT1, leading to destabilization of the CD147–MCT1 complex, and BSG (CD147) knockdown phenocopies the teratogenic effects of thalidomide exposure in zebrafish.
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ProteomicsDB: a multi-omics and multi-organism resource for life science research.
Patroklos Samaras,Tobias Schmidt,Martin Frejno,Siegfried Gessulat,Maria Reinecke,Maria Reinecke,Maria Reinecke,Anna Jarzab,Jana Zecha,Julia Mergner,Piero Giansanti,Hans-Christian Ehrlich,Stephan Aiche,Johannes Rank,Harald Kienegger,Helmut Krcmar,Bernhard Kuster,Mathias Wilhelm +17 more
TL;DR: A new service in ProteomicsDB is introduced which allows users to upload their own expression datasets and analyze them alongside with data stored in ProeomicsDB, and supports the storage and visualization of data collected from other organisms, exemplified by Arabidopsis thaliana.