B
Bernhard Kuster
Researcher at Technische Universität München
Publications - 310
Citations - 37543
Bernhard Kuster is an academic researcher from Technische Universität München. The author has contributed to research in topics: Proteome & Proteomics. The author has an hindex of 79, co-authored 277 publications receiving 31872 citations. Previous affiliations of Bernhard Kuster include GlaxoSmithKline & German Cancer Research Center.
Papers
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Journal ArticleDOI
Measuring and managing ratio compression for accurate iTRAQ/TMT quantification.
Mikhail M. Savitski,Toby Mathieson,Nico Zinn,Gavain Sweetman,Carola Doce,Isabelle Becher,Fiona Pachl,Bernhard Kuster,Bernhard Kuster,Marcus Bantscheff +9 more
TL;DR: An algorithm is devised that corrects experimental TMT ratios on the basis of determined peptide interference levels and the quantification accuracy achieved was comparable to that obtained with stringent spectrum filters but limited the loss in coverage to <10%.
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Enterococcus faecalis metalloprotease compromises epithelial barrier and contributes to intestinal inflammation
Natalie Steck,Micha Hoffmann,Irina Sava,Sandra C. Kim,Hannes Hahne,Susan L. Tonkonogy,Susan L. Tonkonogy,Katrin Mair,Dagmar Krueger,Mihaela Pruteanu,Fergus Shanahan,Roger Vogelmann,Michael Schemann,Bernhard Kuster,R. Balfor Sartor,Dirk Haller +15 more
TL;DR: The metalloprotease GelE, produced by commensal strains of E faecalis, contributes to development of chronic intestinal inflammation in mice that are susceptible to intestinal inflammation (IL-10(-/-) and TNF(ΔARE/Wt) mice) by impairing epithelial barrier integrity.
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A multivariate approach to the integration of multi-omics datasets
TL;DR: Multiple co-inertia analysis (MCIA), an exploratory data analysis method that identifies co-relationships between multiple high dimensional datasets, is described, an attractive method for data integration and visualization of several datasets of multi-omics features observed on the same set of individuals.
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A transmembrane tight junction protein selectively expressed on endothelial cells and platelets
Ines Nasdala,Karen Wolburg-Buchholz,Karen Wolburg-Buchholz,Hartwig Wolburg,Annegret Kuhn,Klaus Ebnet,Gertrud Brachtendorf,Ulrike Samulowitz,Bernhard Kuster,Britta Engelhardt,Dietmar Vestweber,Dietmar Vestweber,Stefan Butz +12 more
TL;DR: The 1G8 antigen was not detected on peripheral blood mouse leukocytes, whereas similar to JAM-1 it was strongly expressed on platelets and megakaryocytes, and supports homophilic interactions on transfected Chinese hamster ovary cells.
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Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry
Paul Ajuh,Bernhard Kuster,Kostya I. Panov,Joost C. B. M. Zomerdijk,Matthias Mann,Angus I. Lamond +5 more
TL;DR: A first purification and characterization of a functional, human non‐snRNA spliceosome subunit containing CDC5L and at least five additional protein factors is reported.