B
Bijan Boldajipour
Researcher at Pfizer
Publications - 30
Citations - 3155
Bijan Boldajipour is an academic researcher from Pfizer. The author has contributed to research in topics: Chimeric antigen receptor & Antigen. The author has an hindex of 13, co-authored 23 publications receiving 2697 citations. Previous affiliations of Bijan Boldajipour include Max Planck Society & University of Münster.
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Journal ArticleDOI
Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity
Miranda Broz,Mikhail Binnewies,Bijan Boldajipour,Amanda E. Nelson,Joshua L. Pollack,David J. Erle,Andrea J. Barczak,Michael Rosenblum,Adil Daud,Diane L. Barber,Sebastian Amigorena,Laura J. van't Veer,Anne I. Sperling,Denise M. Wolf,Matthew F. Krummel +14 more
TL;DR: Across multiple mouse tumor models and human tumor biopsies, the intratumoral dendritic cell (DC) populations are delineated as distinct from macrophage populations, and CD103(+) DCs are extremely sparse and yet remarkably capable CTL stimulators.
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RNA-binding protein Dnd1 inhibits microRNA access to target mRNA.
Martijn Kedde,Markus J. Strasser,Bijan Boldajipour,Joachim A.F. Oude Vrielink,Krasimir Slanchev,Carlos le Sage,Remco Nagel,P. Mathijs Voorhoeve,Josyanne van Duijse,Ulf Andersson Ørom,Anders H. Lund,Anastassis Perrakis,Erez Raz,Reuven Agami +13 more
TL;DR: It is demonstrated that the expression of dead end 1 (Dnd1), an evolutionary conserved RNA-binding protein (RBP), counteracts the function of several miRNAs in human cells and in primordial germ cells of zebrafish by binding mRNAs and prohibiting miRNAAs from associating with their target sites.
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Control of Chemokine-Guided Cell Migration by Ligand Sequestration
Bijan Boldajipour,Harsha Mahabaleshwar,Elena Kardash,Michal Reichman-Fried,Heiko Blaser,Sofia Minina,Duncan Wilson,Qiling Xu,Erez Raz +8 more
TL;DR: It is demonstrated that the activity of a second SDF-1/CXCL12 receptor, CXCR7, is crucial for proper migration of PGCs toward their targets and functions primarily in the somatic environment rather than within the migrating cells.
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Marginating Dendritic Cells of the Tumor Microenvironment Cross-present Tumor Antigens and Stably Engage Tumor-Specific T cells
John J. Engelhardt,Bijan Boldajipour,Peter Beemiller,Priya Pandurangi,Caitlin M. Sorensen,Zena Werb,Mikala Egeblad,Mikala Egeblad,Matthew F. Krummel +8 more
TL;DR: It is determined that infiltrating tumor-specific T cells engage in long-lived interactions with bone-marrow-derived cells, proximal to the tumor, and spatiotemporal dynamics revealed here implicate nonproductive interactions between T-cells and antigen-presenting cells on the tumor margin.
Journal ArticleDOI
A role for Rho GTPases and cell-cell adhesion in single-cell motility in vivo.
Elena Kardash,Michal Reichman-Fried,Jean-Léon Maître,Bijan Boldajipour,Ekaterina Papusheva,Esther-Maria Messerschmidt,Carl-Philipp Heisenberg,Erez Raz +7 more
TL;DR: It is proposed that actin-rich structures undergoing retrograde flow are essential for the generation of E-cadherin-mediated traction forces between the germ cells and the surrounding tissue and are therefore crucial for cell motility in vivo.