Control of Chemokine-Guided Cell Migration by Ligand Sequestration
Bijan Boldajipour,Harsha Mahabaleshwar,Elena Kardash,Michal Reichman-Fried,Heiko Blaser,Sofia Minina,Duncan Wilson,Qiling Xu,Erez Raz +8 more
TLDR
It is demonstrated that the activity of a second SDF-1/CXCL12 receptor, CXCR7, is crucial for proper migration of PGCs toward their targets and functions primarily in the somatic environment rather than within the migrating cells.About:
This article is published in Cell.The article was published on 2008-02-08 and is currently open access. It has received 577 citations till now. The article focuses on the topics: Cell migration & Somatic cell.read more
Citations
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Collective cell migration in morphogenesis, regeneration and cancer
Peter Friedl,Darren Gilmour +1 more
TL;DR: Comparing different types of collective migration at the molecular and cellular level reveals a common mechanistic theme between developmental and cancer research.
Journal ArticleDOI
Oogenesis in teleosts: How fish eggs are formed
TL;DR: Recent advances on teleost fish oocyte differentiation, maturation and ovulation are highlighted, including those involved in the degeneration and reabsorption of ovarian follicles (atresia).
Journal ArticleDOI
The Chemokine Superfamily Revisited
Albert Zlotnik,Osamu Yoshie +1 more
TL;DR: The full scope of the human and mouse chemokine superfamilies and their relationships are updated and several important roles that homeostatic chemokines play in the immune system are summarized.
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International Union of Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors
Françoise Bachelerie,Adit Ben-Baruch,Amanda M. Burkhardt,Christophe Combadière,Joshua M. Farber,Gerard J. Graham,Richard Horuk,Alexander Hovard Sparre-Ulrich,Massimo Locati,Andrew D. Luster,Alberto Mantovani,Kouji Matsushima,Philip M. Murphy,Robert J. B. Nibbs,Hisayuki Nomiyama,Christine Power,Amanda E. I. Proudfoot,Mette M. Rosenkilde,Antal Rot,Silvano Sozzani,Marcus Thelen,Osamu Yoshie,Albert Zlotnik +22 more
TL;DR: This work reviews this extended family of chemokine receptors and Chemokine-binding proteins at the basic, translational, and clinical levels, including an update on drug development and introduces a new nomenclature for atypical chemokin receptors with the stem ACKR (atypicalChemokine receptor).
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CXCL12 / CXCR4 / CXCR7 chemokine axis and cancer progression.
Xueqing Sun,Guangcun Cheng,Mingang Hao,Jianghua Zheng,Xiaoming Zhou,Jian Zhang,Russell S. Taichman,Kenneth J. Pienta,Jianhua Wang +8 more
TL;DR: The current concepts regarding the role of CXCL12 / CXCR4 / CxCR7 axis activation, which regulates the pattern of tumor growth and metastatic spread to organs expressing high levels of CxCL12 to develop secondary tumors are reviewed.
References
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Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
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Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion
Akira Orimo,Piyush Gupta,Dennis C. Sgroi,Fernando Arenzana-Seisdedos,Thierry Delaunay,Rizwan Naeem,Vincent J. Carey,Andrea L. Richardson,Robert A. Weinberg +8 more
TL;DR: Using a coimplantation tumor xenograft model, it is demonstrated that carcinoma-associated fibroblasts extracted from human breast carcinomas promote the growth of admixed breast carcinoma cells significantly more than do normal mammaries derived from the same patients.
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Effective targeted gene ‘knockdown’ in zebrafish
TL;DR: It is shown here that antisense, morpholino-modified oligonucleotides (morpholinos) are effective and specific translational inhibitors in zebrafish, and conserved vertebrate processes and diseases are now amenable to a systematic, in vivo, reverse-genetic paradigm using zebra fish embryos.
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Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
TL;DR: This is the first demonstration of the involvement of a G-protein-coupled chemokine receptor in neuronal cell migration and patterning in the central nervous system and may be important for designing strategies to block HIV entry into cells and for understanding mechanisms of pathogenesis in AIDS dementia.
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Resolution of inflammation: the beginning programs the end.
Charles N. Serhan,John Savill +1 more
TL;DR: Emerging evidence now suggests that an active, coordinated program of resolution initiates in the first few hours after an inflammatory response begins, and the mechanism required for inflammation resolution may underpin the development of drugs that can resolve inflammatory processes in directed and controlled ways.