B
Brad Wouters
Researcher at University Health Network
Publications - 32
Citations - 1235
Brad Wouters is an academic researcher from University Health Network. The author has contributed to research in topics: Radiation therapy & Internal medicine. The author has an hindex of 12, co-authored 26 publications receiving 1117 citations. Previous affiliations of Brad Wouters include Maastricht University Medical Centre & Ontario Institute for Cancer Research.
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Journal ArticleDOI
Chronic Hypoxia Decreases Synthesis of Homologous Recombination Proteins to Offset Chemoresistance and Radioresistance
Norman Chan,Marianne Koritzinsky,Helen Zhao,Helen Zhao,Ranjit S. Bindra,Peter M. Glazer,Simon N. Powell,Abdellah Belmaaza,Brad Wouters,Robert G. Bristow +9 more
TL;DR: Persistent down-regulation of HR function by the tumor microenvironment could result in low-fidelity DNA repair and have significant implications for response to therapy and genetic instability in human cancers.
Journal ArticleDOI
E-Cadherin loss associated with EMT promotes radioresistance in human tumor cells.
Jan Theys,Barry Jutten,Roger Habets,Kim Paesmans,Arjan J. Groot,Philippe Lambin,Brad Wouters,Brad Wouters,Brad Wouters,Guido Lammering,Marc Vooijs +10 more
TL;DR: A mechanism by which the tumor microenvironment may contribute to tumor radioresistance via E-cadherin loss and EMT is described.
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Increased therapeutic ratio by 18FDG-PET CT planning in patients with clinical CT stage N2-N3M0 non–small-cell lung cancer: A modeling study
Antoinet van Der Wel,Sebastiaan M. J. J. G. Nijsten,Monique Hochstenbag,R.J.S. Lamers,Liesbeth J. Boersma,Rinus Wanders,Ludy C.H.W. Lutgens,Michael Zimny,Søren M. Bentzen,Brad Wouters,Philippe Lambin,Dirk De Ruysscher +11 more
TL;DR: In this group of clinical CT Stage N2-N3 NSCLC patients, use of FDG-PET scanning information in radiotherapy planning reduced the radiation exposure of the esophagus and lung, and thus allowed significant radiation dose escalation while respecting all relevant normal tissue constraints.
Journal ArticleDOI
Effects of radiotherapy planning with a dedicated combined PET-CT-simulator of patients with non-small cell lung cancer on dose limiting normal tissues and radiation dose-escalation: a planning study.
Dirk De Ruysscher,S Wanders,André Minken,Aniek Lumens,Jacqueline Schiffelers,Cissie Stultiens,Serve Halders,Liesbeth J. Boersma,Angela van Baardwijk,Tom Verschueren,Monique Hochstenbag,Gabriel Snoep,Brad Wouters,Sebastiaan M. J. J. G. Nijsten,Søren M. Bentzen,Marinus J.P.G. van Kroonenburgh,Michel Öllers,Philippe Lambin +17 more
TL;DR: The use of a combined dedicated PET-CT-simulator reduced radiation exposure of the oesophagus and the lung, and thus allowed significant radiation dose escalation whilst respecting all relevant normal tissue constraints.
Journal ArticleDOI
Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium
Erik O. Pettersen,Peter Ebbesen,Peter Ebbesen,Roben G. Gieling,Kaye J. Williams,Ludwig Dubois,Philippe Lambin,Carol Ward,James Meehan,Ian Kunkler,Simon P. Langdon,Anne Hansen Ree,Kjersti Flatmark,Heidi Lyng,Maria J. Calzada,Luis del Peso,Manuel O. Landázuri,Agnes Görlach,Hubert Flamm,Jochen Kieninger,Gerald Urban,Andreas Weltin,Dean C. Singleton,Syed Haider,Francesca M. Buffa,Adrian L. Harris,Andrea Scozzafava,Claudiu T. Supuran,Isabella Moser,Gerhard Jobst,Morten Busk,Kasper Toustrup,Jens Overgaard,Jan Alsner,Jacques Pouysségur,Johanna Chiche,Nathalie M. Mazure,Ibtissam Marchiq,Scott K. Parks,Afshan Ahmed,Margaret Ashcroft,Silvia Pastorekova,Yihai Cao,Kasper M.A. Rouschop,Brad Wouters,Marianne Koritzinsky,Hilda Mujcic,Dan Cojocari +47 more
TL;DR: A large-scale collaborative EU-financed project 2009–2014 denoted METOXIA has studied all the mentioned aspects of hypoxia with the aim of selecting potential targets for new hypoxIA-specific therapy and develop the first stage of tests for this therapy.