R
Roger Habets
Researcher at Maastricht University
Publications - 9
Citations - 781
Roger Habets is an academic researcher from Maastricht University. The author has contributed to research in topics: Notch signaling pathway & Receptor. The author has an hindex of 9, co-authored 9 publications receiving 666 citations. Previous affiliations of Roger Habets include Katholieke Universiteit Leuven & Maastricht University Medical Centre.
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Journal ArticleDOI
Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool
Ragna Sannerud,Cary Esselens,Paulina Ejsmont,Rafael Mattera,Leila Rochin,Leila Rochin,Arun Kumar Tharkeshwar,Greet De Baets,Veerle De Wever,Roger Habets,Veerle Baert,Wendy Vermeire,Christine Michiels,Arjan J. Groot,Rosanne Wouters,Katleen Dillen,Katlijn Vints,Pieter Baatsen,Sebastian Munck,Rita Derua,Etienne Waelkens,Guriqbal S. Basi,M Mercken,Marc Vooijs,Mathieu Bollen,Joost Schymkowitz,Frederic Rousseau,Juan S. Bonifacino,Guillaume van Niel,Guillaume van Niel,Bart De Strooper,Bart De Strooper,Wim Annaert +32 more
TL;DR: In this article, the authors examined the significance of this heterogeneity and identified a unique motif in PSEN2 that directs this γ-secretase to late endosomes/lysosomes via a phosphorylationdependent interaction with the AP-1 adaptor complex.
Journal ArticleDOI
E-Cadherin loss associated with EMT promotes radioresistance in human tumor cells.
Jan Theys,Barry Jutten,Roger Habets,Kim Paesmans,Arjan J. Groot,Philippe Lambin,Brad Wouters,Brad Wouters,Brad Wouters,Guido Lammering,Marc Vooijs +10 more
TL;DR: A mechanism by which the tumor microenvironment may contribute to tumor radioresistance via E-cadherin loss and EMT is described.
Journal ArticleDOI
Regulated Proteolysis of NOTCH2 and NOTCH3 Receptors by ADAM10 and Presenilins
Arjan J. Groot,Roger Habets,Sanaz Yahyanejad,Caroline M. Hodin,Karina Reiss,Paul Saftig,Jan Theys,Marc Vooijs +7 more
TL;DR: It is demonstrated that canonical ligand-induced proteolysis of the NOTCH1, -2, and -3 receptors strictly depends on consecutive cleavage of these receptors by ADAM10 and the presenilin-containing γ-secretase complex, leading to transcriptional activation.
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NOTCH blockade combined with radiation therapy and temozolomide prolongs survival of orthotopic glioblastoma
Sanaz Yahyanejad,Henry King,Venus Sosa Iglesias,Patrick V. Granton,Patrick V. Granton,Lydie M. O. Barbeau,Stefan J. van Hoof,Arjan J. Groot,Roger Habets,Jos Prickaerts,Anthony J. Chalmers,Daniëlle B.P. Eekers,Jan Theys,Susan C Short,Frank Verhaegen,Marc Vooijs +15 more
TL;DR: Findings indicate that NOTCH inhibition combined with standard of care treatment has an anti-glioma stem cell effect which provides an improved survival benefit for GBM and encourages further translational and clinical studies.
Journal ArticleDOI
Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition
Roger Habets,Charles E. de Bock,Charles E. de Bock,Lutgarde Serneels,Inge Lodewijckx,Delphine Verbeke,David Nittner,Rajeshwar Narlawar,Sofie Demeyer,James Dooley,Adrian Liston,Tom Taghon,Jan Cools,Bart De Strooper,Bart De Strooper +14 more
TL;DR: It is demonstrated that genetic deletion or pharmacologic inhibition of the presenilin-1 (PSEN1) subclass of γ-secretase complexes is highly effective in decreasing leukemia while avoiding dose-limiting toxicities.