Brandon J. Mannion

TL;DR: It is shown that the pervasive presence of multiple enhancers with similar activities near the same gene confers phenotypic robustness to loss-of-function mutations in individual enhancers.

TL;DR: Significant changes in a regulatory sequence associated with a major body plan transition are demonstrated and highlighted the role of enhancers in morphological evolution.

TL;DR: Analysis of chromatin state and accessibility in mouse tissues from twelve sites and eight developmental stages provides the most comprehensive view of Chromatin dynamics to date.

TL;DR: This integrative analysis offers an initial picture of the consequences of Chd8 haploinsufficiency for brain development and identified a co-expression module with peak expression in early brain development featuring dysregulation of RNA processing, chromatin remodeling and cell-cycle genes enriched for promoter binding by ChD8.

TL;DR: It is shown that ultraconserved enhancers are required for normal development and indicates that remarkably strong sequence conservation likely results from fitness deficits that appear subtle in a laboratory setting.