Brett Adair

TL;DR: The data suggest that the LPS/TNF-α-dependent regulation of miR-155 and miR -125b may be implicated in the response to endotoxin shock, thus offering new targets for drug design.

TL;DR: It is shown that overexpression of miR-155 significantly down-regulates the core MMR proteins, hMSH2, h MSH6, and hMLH1, inducing a mutator phenotype and MSI, and support for miR -155 modulation of MMR as a mechanism of cancer pathogenesis is provided.

TL;DR: This mechanism provides a novel pathogenetic model for the association of 13q deletions with the indolent form of CLL that involves microRNAs, TP53, and ZAP70 and its downstream effectors.

TL;DR: It is established that, in human THP-1 monocytic cells as well as in human blood monocytes, resveratrol upregulates miR-663, a microRNA potentially targeting multiple genes implicated in the immune response, and that the effects of resver atrol on both AP-1 activity and JunB levels are dose dependent.

TL;DR: This review focuses on how epigenetics affects the miRNome and how the recently identified epi-miRNAs regulate the epigenome in human cancers, ultimately contributing to human carcinogenesis.