B
Brian P. Danysh
Researcher at Broad Institute
Publications - 37
Citations - 1070
Brian P. Danysh is an academic researcher from Broad Institute. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 12, co-authored 21 publications receiving 696 citations. Previous affiliations of Brian P. Danysh include Rice University & University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers.
Aparna Raj Parikh,Ignaty Leshchiner,Liudmila Elagina,Lipika Goyal,Chaya Levovitz,Giulia Siravegna,Dimitri Livitz,Kahn Rhrissorrakrai,Elizabeth E. Martin,Emily E. Van Seventer,Megan Hanna,Kara Slowik,Filippo Utro,Christopher J. Pinto,Alicia Wong,Brian P. Danysh,Ferran Fece de la Cruz,Isobel J Fetter,Brandon Nadres,Heather A. Shahzade,Jill N. Allen,Lawrence S. Blaszkowsky,Jeffrey W. Clark,Bruce J. Giantonio,Janet E. Murphy,Ryan D. Nipp,Eric Roeland,David P. Ryan,Colin D. Weekes,Eunice L. Kwak,Jason E. Faris,Jennifer Y. Wo,François Aguet,Ipsita Dey-Guha,Mehlika Hazar-Rethinam,Dora Dias-Santagata,David T. Ting,Andrew X. Zhu,Theodore S. Hong,Todd R. Golub,Todd R. Golub,Todd R. Golub,A. John Iafrate,Viktor A. Adalsteinsson,Alberto Bardelli,Laxmi Parida,Dejan Juric,Gad Getz,Ryan B. Corcoran +48 more
TL;DR: Direct prospective comparison of circulating tumor DNA and tissue biopsy sequencing shows the superiority of liquid biopsies for capturing clinically relevant alterations mediating resistance to targeted therapies in cancer patients.
Journal ArticleDOI
The lens capsule.
TL;DR: This review covers the development and structure of the lens capsule, lens diseases associated with mutations in extracellular matrix genes and the role of the capsule in lens function including those proposed for visual accommodation, selective permeability to infectious agents, and cell signaling.
Journal ArticleDOI
Abnormal Expression of Collagen IV in Lens Activates Unfolded Protein Response Resulting in Cataract
Zeynep Firtina,Brian P. Danysh,Xiaoyang Bai,Douglas B. Gould,Takehiro Kobayashi,Melinda K. Duncan +5 more
TL;DR: In vivo evidence is provided for a role of UPR in cataract formation in response to accumulation of terminally unfolded proteins in the endoplasmic reticulum using two different mouse models.
Journal ArticleDOI
BRAF inhibitors: experience in thyroid cancer and general review of toxicity.
Maria E. Cabanillas,A. Patel,Brian P. Danysh,Ramona Dadu,Scott Kopetz,Gerald Steven Falchook +5 more
TL;DR: The management of vemurafenib and dabrafenib toxicities is applicable across all tumor types and may serve as a practical guide to their use.
Journal ArticleDOI
Parallel Genomic Alterations of Antigen and Payload Targets Mediate Polyclonal Acquired Clinical Resistance to Sacituzumab Govitecan in Triple-Negative Breast Cancer.
James Coates,Sheng Sun,Ignaty Leshchiner,Nayana Thimmiah,Elizabeth E. Martin,Daniel E. McLoughlin,Brian P. Danysh,Kara Slowik,Raquel A. Jacobs,Kahn Rhrissorrakrai,Filippo Utro,Chaya Levovitz,Elyssa Denault,Charlotte S. Walmsley,Avinash Kambadakone,James R. Stone,Steven J. Isakoff,Laxmi Parida,Dejan Juric,Gad Getz,Aditya Bardia,Leif W. Ellisen +21 more
TL;DR: In this article, the authors identify mechanisms of SG resistance through RNA and whole-exome sequencing of pretreatment and post-progression specimens, highlighting the specificity of SG and illustrates how such mechanisms will inform therapeutic strategies to overcome ADC resistance.