María Martínez-Iniesta

TL;DR: Tumor TS 1494del6 genotype may be a prognostic factor in FU-based adjuvant treatment of colorectal cancer patients and is associated with a better outcome than the 3R/3R genotype.

TL;DR: It is reported that TP53TG1 is an lncRNA that is critical for the correct response of p53 to DNA damage that undergoes cancer-specific promoter hypermethylation-associated silencing and binds to the multifaceted DNA/RNA binding protein YBX1 to prevent its nuclear localization and thus the YBx1-mediated activation of oncogenes.

TL;DR: It is found that epigenetic reactivation of TBC1D16-47KD is associated with poor clinical outcome in melanoma, while conferring greater sensitivity to BRAF and MEK inhibitors and RAB5C is identified as a new TBC 1D16 target and it is shown that it regulates EGFR in melanomas cells.

TL;DR: It is found that human glioma cells undergo DNA methylation-associated epigenetic silencing of NSUN5, a candidate RNA methyltransferase for 5-methylcytosine, which exhibits tumor-suppressor characteristics in vivo gliomas models and leads to the emergence of an adaptive translational program for survival under conditions of cellular stress.

TL;DR: Preclinical orthotopically perpetuated ovarian tumor grafts are useful tools for drug development, providing hard evidence that lurbinectedin might be a useful therapy in the treatment of EOC by overcoming cisplatin resistance.