R
Robert J. Young
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 132
Citations - 5447
Robert J. Young is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Glioma & Cancer. The author has an hindex of 34, co-authored 132 publications receiving 3724 citations. Previous affiliations of Robert J. Young include Cornell University & Montefiore Medical Center.
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Journal ArticleDOI
Gliomas: Predicting Time to Progression or Survival with Cerebral Blood Volume Measurements at Dynamic Susceptibility-weighted Contrast-enhanced Perfusion MR Imaging
Meng Law,Robert J. Young,James S. Babb,Nicole Peccerelli,Sophie Chheang,Michael L. Gruber,Douglas C. Miller,John G. Golfinos,David Zagzag,Glyn Johnson +9 more
TL;DR: Dynamic susceptibility-weighted contrast material-enhanced perfusion MR imaging can be used to predict median time to progression in patients with gliomas, independent of pathologic findings.
Journal ArticleDOI
Tracking tumour evolution in glioma through liquid biopsies of cerebrospinal fluid
Alexandra Miller,Ronak Shah,Elena Pentsova,Maryam Pourmaleki,Samuel Briggs,Natalie DiStefano,Youyun Zheng,Anna Skakodub,Smrutiben A. Mehta,Carl Campos,Wan-Ying Hsieh,S. Duygu Selcuklu,Lilan Ling,Fanli Meng,Xiaohong Jing,Aliaksandra Samoila,Tejus Bale,Dana W.Y. Tsui,Christian Grommes,Agnes Viale,Mark M. Souweidane,Mark M. Souweidane,Viviane Tabar,Cameron Brennan,Anne S. Reiner,Marc K. Rosenblum,Katherine S. Panageas,Lisa M. DeAngelis,Robert J. Young,Michael F. Berger,Ingo K. Mellinghoff,Ingo K. Mellinghoff +31 more
TL;DR: It is shown that tumour-derived DNA was detected in CSF from 42 out of 85 patients (49.4%) and was associated with disease burden and adverse outcome and the ability to monitor the evolution of the glioma genome through a minimally invasive technique could advance the clinical development and use of genotype-directed therapies for gliomas.
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Long-term risk of radionecrosis and imaging changes after stereotactic radiosurgery for brain metastases.
Zachary A. Kohutek,Yoshiya Yamada,Timothy A. Chan,Cameron Brennan,Viviane Tabar,Philip H. Gutin,T. Jonathan Yang,Marc K. Rosenblum,Åse Ballangrud,Robert J. Young,Zhigang Zhang,Kathryn Beal +11 more
TL;DR: This data demonstrates that with close imaging follow-up, radionecrosis after single-fraction SRS for brain metastases is not uncommon, and maximum tumor diameter on pre-treatment MR imaging can provide a reliable estimate of radionicrosis risk prior to treatment planning, with the greatest risk among tumors measuring >1 cm.
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Quantitative imaging biomarkers alliance (QIBA) recommendations for improved precision of DWI and DCE‐MRI derived biomarkers in multicenter oncology trials
Amita Shukla-Dave,Nancy A. Obuchowski,Thomas L. Chenevert,Sachin Jambawalikar,Lawrence H. Schwartz,Dariya I. Malyarenko,Wei Huang,Susan M. Noworolski,Robert J. Young,Mark S. Shiroishi,Harrison Kim,Catherine Coolens,Hendrik Laue,Caroline Chung,Mark A. Rosen,Michael A. Boss,Edward F. Jackson +16 more
TL;DR: This review focuses on the need for QIBs in oncology applications and emphasizes the importance of the assessment of their reproducibility and repeatability.
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Randomized Phase II Trial of Nivolumab With Stereotactic Body Radiotherapy Versus Nivolumab Alone in Metastatic Head and Neck Squamous Cell Carcinoma.
Sean McBride,Eric J. Sherman,Eric J. Sherman,C. Jillian Tsai,Shrujal S. Baxi,Jahan Aghalar,Juliana Eng,Wanqing Iris Zhi,Daniel C. McFarland,Loren S. Michel,Robert J. Young,Robert A. Lefkowitz,D. Spielsinger,Zhigang Zhang,Jessica Flynn,Lara Dunn,Lara Dunn,Alan L. Ho,Alan L. Ho,Nadeem Riaz,David G. Pfister,David G. Pfister,Nancy Y. Lee +22 more
TL;DR: No improvement in response was found and no evidence of an abscopal effect with the addition of SBRT to nivolumab in unselected patients with metastatic HNSCC.