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Caroline L Relton
Researcher at University of Bristol
Publications - 433
Citations - 25612
Caroline L Relton is an academic researcher from University of Bristol. The author has contributed to research in topics: DNA methylation & Mendelian randomization. The author has an hindex of 71, co-authored 394 publications receiving 17221 citations. Previous affiliations of Caroline L Relton include Health Science University & University of Newcastle.
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Journal ArticleDOI
DNA methylation and substance-use risk: a prospective, genome-wide study spanning gestation to adolescence.
Charlotte A.M. Cecil,Esther Walton,Esther Walton,Rebecca G. Smith,Essi Viding,Eamon McCrory,Caroline L Relton,Matthew Suderman,Jean-Baptiste Pingault,Wendy L. McArdle,Tom R. Gaunt,Jonathan Mill,Edward D. Barker +12 more
TL;DR: Findings lend novel insights into epigenetic correlates of substance use, highlight birth as a potentially sensitive window of biological vulnerability and provide preliminary evidence of an indirect epigenetic pathway linking prenatal tobacco exposure and adolescent substance use.
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Adversity exposure during sensitive periods predicts accelerated epigenetic aging in children
Sandro Marini,Kathryn A. Davis,Thomas W. Soare,Yiwen Zhu,Matthew Suderman,Andrew J Simpkin,Andrew D A C Smith,Erika J. Wolf,Caroline L Relton,Erin C. Dunn +9 more
TL;DR: Exposure to abuse, financial hardship, or neighborhood disadvantage during sensitive periods in early and middle childhood best explained variability in the deviation of Hannum-based epigenetic age from chronological age, even after considering the role of adversity accumulation and recency.
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An epigenome-wide association meta-analysis of prenatal maternal stress in neonates: A model approach for replication.
Jolien Rijlaarsdam,Irene Pappa,Esther Walton,Marian J. Bakermans-Kranenburg,Viara R. Mileva-Seitz,Ralph C. A. Rippe,Sabine J. Roza,Vincent W. V. Jaddoe,Frank C. Verhulst,Janine F. Felix,Charlotte A.M. Cecil,Caroline L Relton,Tom R. Gaunt,Wendy L. McArdle,Jonathan Mill,Edward D. Barker,Henning Tiemeier,Marinus H. van IJzendoorn +17 more
TL;DR: Combining data from two independent population-based samples in an epigenome-wide meta-analysis indicates that there are no large effects of prenatal maternal stress exposure on neonatal DNA methylation.
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Prenatal nutrition, epigenetics and schizophrenia risk: can we test causal effects?
James B. Kirkbride,James B. Kirkbride,Ezra Susser,Marija Kundakovic,Jacob K. Kresovich,George Davey Smith,Caroline L Relton +6 more
TL;DR: Evidence that prenatal nutrition is linked to epigenetic outcomes in offspring and schizophrenia in offspring, and that schizophrenia is associated with epigenetic changes is considered, and one-carbon metabolism is focused upon as a mediator of the pathway between perturbed prenatal nutrition and the subsequent risk of schizophrenia.
Journal ArticleDOI
Tracking the Epigenetic Clock Across the Human Life Course: A Meta-analysis of Longitudinal Cohort Data
Riccardo E. Marioni,Matthew Suderman,Brian H. Chen,Steve Horvath,Stefania Bandinelli,Tiffany Morris,Stephan Beck,Luigi Ferrucci,Nancy L. Pedersen,Caroline L Relton,Ian J. Deary,Sara Hägg +11 more
TL;DR: Epigenetic age increases at a slower rate than chronological age across the life course, especially in the oldest population, where some of the effect is likely driven by survival bias.