J
Jacob K. Kresovich
Researcher at National Institutes of Health
Publications - 39
Citations - 1013
Jacob K. Kresovich is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Breast cancer & Medicine. The author has an hindex of 14, co-authored 34 publications receiving 585 citations. Previous affiliations of Jacob K. Kresovich include Northwestern University & Columbia University.
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Journal ArticleDOI
Methylation-Based Biological Age and Breast Cancer Risk.
Jacob K. Kresovich,Zongli Xu,Katie M. O'Brien,Clarice R. Weinberg,Dale P. Sandler,Jack A. Taylor +5 more
TL;DR: DNA methylation-based measures of biological age may be important predictors of breast cancer risk, and age acceleration in premenopausal women independently predicted breast cancer.
Journal ArticleDOI
Exploring DNA methylation changes in promoter, intragenic, and intergenic regions as early and late events in breast cancer formation
Garth H. Rauscher,Jacob K. Kresovich,Matthew Poulin,Liying Yan,Virgilia Macias,Abeer M. Mahmoud,Umaima Al-Alem,Andre Kajdacsy-Balla,Elizabeth L. Wiley,Debra A. Tonetti,Melanie Ehrlich +10 more
TL;DR: Examination of transcriptome and DNA methylation databases indicated that methylation at three non-promoter regions was associated with higher gene expression, unlike the inverse associations between cancer DNA hypermethylation and cancer-altered gene expression usually reported.
Journal ArticleDOI
Prenatal nutrition, epigenetics and schizophrenia risk: can we test causal effects?
James B. Kirkbride,James B. Kirkbride,Ezra Susser,Marija Kundakovic,Jacob K. Kresovich,George Davey Smith,Caroline L Relton +6 more
TL;DR: Evidence that prenatal nutrition is linked to epigenetic outcomes in offspring and schizophrenia in offspring, and that schizophrenia is associated with epigenetic changes is considered, and one-carbon metabolism is focused upon as a mediator of the pathway between perturbed prenatal nutrition and the subsequent risk of schizophrenia.
Journal ArticleDOI
Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging.
Daniel L. McCartney,Josine L. Min,Rebecca C Richmond,Ake T. Lu,Maria K. Sobczyk,Gail Davies,Linda Broer,Xiuqing Guo,Ayoung Jeong,Ayoung Jeong,Jeesun Jung,Silva Kasela,Seyma Katrinli,Pei-Lun Kuo,Pamela R. Matias-Garcia,Pashupati P. Mishra,Marianne Nygaard,Marianne Nygaard,Teemu Palviainen,Amit Patki,Laura M. Raffield,Scott M. Ratliff,Tom G. Richardson,Oliver Robinson,Mette Soerensen,Mette Soerensen,Dianjianyi Sun,Pei-Chien Tsai,Pei-Chien Tsai,Pei-Chien Tsai,Matthijs D. van der Zee,Matthijs D. van der Zee,Rosie M. Walker,Xiaochuan Wang,Yunzhang Wang,Rui Xia,Zongli Xu,Jie Yao,Wei Zhao,Adolfo Correa,Eric Boerwinkle,Pierre Antoine Dugué,Pierre Antoine Dugué,Pierre Antoine Dugué,Peter Durda,Hannah R Elliott,Christian Gieger,Eco J. C. de Geus,Eco J. C. de Geus,Sarah E. Harris,Gibran Hemani,Medea Imboden,Medea Imboden,Mika Kähönen,Sharon L.R. Kardia,Jacob K. Kresovich,Shengxu Li,Kathryn L. Lunetta,Massimo Mangino,Massimo Mangino,Dan Mason,Andrew M. McIntosh,Jonas Mengel-From,Jonas Mengel-From,Ann Zenobia Moore,Joanne M. Murabito,Miina Ollikainen,James S. Pankow,Nancy L. Pedersen,Annette Peters,Silvia Polidoro,David J. Porteous,Olli T. Raitakari,Olli T. Raitakari,Stephen S. Rich,Dale P. Sandler,Elina Sillanpää,Elina Sillanpää,Alicia K. Smith,Melissa C. Southey,Melissa C. Southey,Melissa C. Southey,Konstantin Strauch,Konstantin Strauch,Hemant K. Tiwari,Toshiko Tanaka,Therese Tillin,André G. Uitterlinden,David Van Den Berg,Jenny van Dongen,Jenny van Dongen,James G. Wilson,James G. Wilson,John Wright,Idil Yet,Idil Yet,Donna K. Arnett,Stefania Bandinelli,Jordana T. Bell,Alexandra M. Binder,Dorret I. Boomsma,Dorret I. Boomsma,Wei Chen,Kaare Christensen,Kaare Christensen,Karen N. Conneely,Paul Elliott,Luigi Ferrucci,Myriam Fornage,Sara Hägg,Caroline Hayward,Marguerite R. Irvin,Jaakko Kaprio,Debbie A Lawlor,Terho Lehtimäki,Falk W. Lohoff,Lili Milani,Roger L. Milne,Roger L. Milne,Roger L. Milne,Nicole Probst-Hensch,Nicole Probst-Hensch,Alexander P. Reiner,Beate Ritz,Jerome I. Rotter,Jennifer A. Smith,Jack A. Taylor,Joyce B. J. van Meurs,Paolo Vineis,Melanie Waldenberger,Ian J. Deary,Caroline L Relton,Steve Horvath,Riccardo E. Marioni +133 more
TL;DR: In this article, the authors identify 137 genome-wide significant loci, of which 113 are novel, from genomewide association study (GWAS) meta-analyses of four epigenetic clocks and epigenetic surrogate markers for granulocyte proportions and plasminogen activator inhibitor 1 levels.
Journal ArticleDOI
Associations of lead and cadmium with sex hormones in adult males
TL;DR: After controlling for additional heavy metal exposure, the associations between lead and testosterone as well as cadmium and SHBG remained significant.